Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients
Introduction Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity in Takayasu arteritis (TAK) patients. Method We...
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| Veröffentlicht in: | Clinical rheumatology 2020-04, Vol.39 (4), p.1229-1235 |
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| creator | Wang, Ying Wang, Ya-Hong Tian, Xin-Ping Wang, Hong-Yan Li, Jing Ge, Zhi-Tong Yang, Yun-Jiao Cai, Sheng Zeng, Xiao-Feng Li, Jian-Chu |
| description | Introduction
Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity in Takayasu arteritis (TAK) patients.
Method
We used CEUS to analyze 28 consecutive TAK patients. Disease activity was assessed according to the NIH criteria. We measured CEUS grades and assessed the correlation between contrast features and disease activity.
Results
Higher erythrocyte sedimentation rates (ESRs) were found (35 ± 28.7 vs. 13 ± 7.4 mm/h,
p
|
| doi_str_mv | 10.1007/s10067-019-04698-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2336986271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336986271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a1378d5af9e45d1b96c63528bfec4859fef2b0e98008eedf6899e67bf34fc1023</originalsourceid><addsrcrecordid>eNp9kMlKBDEQhoMoOi4v4EEavHiJZunOcpTBDQa86FFCursytvakxyQtzNsbHTc8eElB6qu_ig-hQ0pOKSHyLOZXSEyoxqQUWmG9gSa05CXWutSbaEKkJJhTrXbQboxPhBCmNN1GO5yWTCklJuhhOvgUbEwY_KP1DbTF2L9_DKNvCzeEAl5tP9rU-XlhQ4LQpS4Wtknda5dWReeLO_tsVzaOv9rLzINPcR9tOdtHOPise-j-8uJueo1nt1c30_MZbrisEraUS9VW1mkoq5bWWjSCV0zVDppSVdqBYzUBrQhRAK0TSmsQsna8dA0ljO-hk3XuMgwvI8RkFl1soO-th2GMhnGe_QgmaUaP_6BPwxh8vs4wJiuZxVYiU2xNNWGIMYAzy9AtbFgZSsy7fLOWb7J88yHf6Dx09Bk91gtov0e-bGeAr4GYW34O4Wf3P7FvbEaRRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2275700756</pqid></control><display><type>article</type><title>Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Wang, Ying ; Wang, Ya-Hong ; Tian, Xin-Ping ; Wang, Hong-Yan ; Li, Jing ; Ge, Zhi-Tong ; Yang, Yun-Jiao ; Cai, Sheng ; Zeng, Xiao-Feng ; Li, Jian-Chu</creator><creatorcontrib>Wang, Ying ; Wang, Ya-Hong ; Tian, Xin-Ping ; Wang, Hong-Yan ; Li, Jing ; Ge, Zhi-Tong ; Yang, Yun-Jiao ; Cai, Sheng ; Zeng, Xiao-Feng ; Li, Jian-Chu</creatorcontrib><description>Introduction
Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity in Takayasu arteritis (TAK) patients.
Method
We used CEUS to analyze 28 consecutive TAK patients. Disease activity was assessed according to the NIH criteria. We measured CEUS grades and assessed the correlation between contrast features and disease activity.
Results
Higher erythrocyte sedimentation rates (ESRs) were found (35 ± 28.7 vs. 13 ± 7.4 mm/h,
p
< 0.01), and CEUS carotid wall enhancement was more frequently (100% vs. 36.6%,
p
< 0.01) seen in TAK patients in the active phase than in those in the inactive phase. With increasing CEUS grades, both the artery wall thickness and ESR increased, and patients were more likely to be in the active phase (0 in grade 0, 42.9% in grade 1, and 75% in grade 2). Receiver operating characteristic (ROC) curve analysis showed that CEUS had an area under the ROC curve (AUC) of 0.872 (95% CI 0.785–0.959,
p
< 0.01), demonstrating good diagnostic accuracy.
Conclusions
Higher CEUS grades reliably identify patients with active TAK.
Key Points
•
No CEUS vascularization is obviously relative with the inactive disease of TAK patients.
•
Obvious CEUS vascularization is obviously relative with the active disease of TAK patients.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-019-04698-9</identifier><identifier>PMID: 31428886</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Arteritis ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - pathology ; Carotid artery ; Contrast Media ; Disease Progression ; Erythrocyte sedimentation rate ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Neovascularization, Pathologic - diagnosis ; Neovascularization, Pathologic - diagnostic imaging ; Original Article ; Rheumatology ; ROC Curve ; Takayasu Arteritis - diagnosis ; Takayasu Arteritis - diagnostic imaging ; Takayasu's disease ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound ; Vascularization ; Vein & artery diseases ; Young Adult</subject><ispartof>Clinical rheumatology, 2020-04, Vol.39 (4), p.1229-1235</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2019</rights><rights>International League of Associations for Rheumatology (ILAR) 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a1378d5af9e45d1b96c63528bfec4859fef2b0e98008eedf6899e67bf34fc1023</citedby><cites>FETCH-LOGICAL-c375t-a1378d5af9e45d1b96c63528bfec4859fef2b0e98008eedf6899e67bf34fc1023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-019-04698-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-019-04698-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31428886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Wang, Ya-Hong</creatorcontrib><creatorcontrib>Tian, Xin-Ping</creatorcontrib><creatorcontrib>Wang, Hong-Yan</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Ge, Zhi-Tong</creatorcontrib><creatorcontrib>Yang, Yun-Jiao</creatorcontrib><creatorcontrib>Cai, Sheng</creatorcontrib><creatorcontrib>Zeng, Xiao-Feng</creatorcontrib><creatorcontrib>Li, Jian-Chu</creatorcontrib><title>Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Introduction
Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity in Takayasu arteritis (TAK) patients.
Method
We used CEUS to analyze 28 consecutive TAK patients. Disease activity was assessed according to the NIH criteria. We measured CEUS grades and assessed the correlation between contrast features and disease activity.
Results
Higher erythrocyte sedimentation rates (ESRs) were found (35 ± 28.7 vs. 13 ± 7.4 mm/h,
p
< 0.01), and CEUS carotid wall enhancement was more frequently (100% vs. 36.6%,
p
< 0.01) seen in TAK patients in the active phase than in those in the inactive phase. With increasing CEUS grades, both the artery wall thickness and ESR increased, and patients were more likely to be in the active phase (0 in grade 0, 42.9% in grade 1, and 75% in grade 2). Receiver operating characteristic (ROC) curve analysis showed that CEUS had an area under the ROC curve (AUC) of 0.872 (95% CI 0.785–0.959,
p
< 0.01), demonstrating good diagnostic accuracy.
Conclusions
Higher CEUS grades reliably identify patients with active TAK.
Key Points
•
No CEUS vascularization is obviously relative with the inactive disease of TAK patients.
•
Obvious CEUS vascularization is obviously relative with the active disease of TAK patients.</description><subject>Adult</subject><subject>Arteritis</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid artery</subject><subject>Contrast Media</subject><subject>Disease Progression</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neovascularization, Pathologic - diagnosis</subject><subject>Neovascularization, Pathologic - diagnostic imaging</subject><subject>Original Article</subject><subject>Rheumatology</subject><subject>ROC Curve</subject><subject>Takayasu Arteritis - diagnosis</subject><subject>Takayasu Arteritis - diagnostic imaging</subject><subject>Takayasu's disease</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Vascularization</subject><subject>Vein & artery diseases</subject><subject>Young Adult</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMlKBDEQhoMoOi4v4EEavHiJZunOcpTBDQa86FFCursytvakxyQtzNsbHTc8eElB6qu_ig-hQ0pOKSHyLOZXSEyoxqQUWmG9gSa05CXWutSbaEKkJJhTrXbQboxPhBCmNN1GO5yWTCklJuhhOvgUbEwY_KP1DbTF2L9_DKNvCzeEAl5tP9rU-XlhQ4LQpS4Wtknda5dWReeLO_tsVzaOv9rLzINPcR9tOdtHOPise-j-8uJueo1nt1c30_MZbrisEraUS9VW1mkoq5bWWjSCV0zVDppSVdqBYzUBrQhRAK0TSmsQsna8dA0ljO-hk3XuMgwvI8RkFl1soO-th2GMhnGe_QgmaUaP_6BPwxh8vs4wJiuZxVYiU2xNNWGIMYAzy9AtbFgZSsy7fLOWb7J88yHf6Dx09Bk91gtov0e-bGeAr4GYW34O4Wf3P7FvbEaRRw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Wang, Ying</creator><creator>Wang, Ya-Hong</creator><creator>Tian, Xin-Ping</creator><creator>Wang, Hong-Yan</creator><creator>Li, Jing</creator><creator>Ge, Zhi-Tong</creator><creator>Yang, Yun-Jiao</creator><creator>Cai, Sheng</creator><creator>Zeng, Xiao-Feng</creator><creator>Li, Jian-Chu</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients</title><author>Wang, Ying ; Wang, Ya-Hong ; Tian, Xin-Ping ; Wang, Hong-Yan ; Li, Jing ; Ge, Zhi-Tong ; Yang, Yun-Jiao ; Cai, Sheng ; Zeng, Xiao-Feng ; Li, Jian-Chu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a1378d5af9e45d1b96c63528bfec4859fef2b0e98008eedf6899e67bf34fc1023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Arteritis</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid artery</topic><topic>Contrast Media</topic><topic>Disease Progression</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neovascularization, Pathologic - diagnosis</topic><topic>Neovascularization, Pathologic - diagnostic imaging</topic><topic>Original Article</topic><topic>Rheumatology</topic><topic>ROC Curve</topic><topic>Takayasu Arteritis - diagnosis</topic><topic>Takayasu Arteritis - diagnostic imaging</topic><topic>Takayasu's disease</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><topic>Vascularization</topic><topic>Vein & artery diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Wang, Ya-Hong</creatorcontrib><creatorcontrib>Tian, Xin-Ping</creatorcontrib><creatorcontrib>Wang, Hong-Yan</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Ge, Zhi-Tong</creatorcontrib><creatorcontrib>Yang, Yun-Jiao</creatorcontrib><creatorcontrib>Cai, Sheng</creatorcontrib><creatorcontrib>Zeng, Xiao-Feng</creatorcontrib><creatorcontrib>Li, Jian-Chu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Ying</au><au>Wang, Ya-Hong</au><au>Tian, Xin-Ping</au><au>Wang, Hong-Yan</au><au>Li, Jing</au><au>Ge, Zhi-Tong</au><au>Yang, Yun-Jiao</au><au>Cai, Sheng</au><au>Zeng, Xiao-Feng</au><au>Li, Jian-Chu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>39</volume><issue>4</issue><spage>1229</spage><epage>1235</epage><pages>1229-1235</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Introduction
Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity in Takayasu arteritis (TAK) patients.
Method
We used CEUS to analyze 28 consecutive TAK patients. Disease activity was assessed according to the NIH criteria. We measured CEUS grades and assessed the correlation between contrast features and disease activity.
Results
Higher erythrocyte sedimentation rates (ESRs) were found (35 ± 28.7 vs. 13 ± 7.4 mm/h,
p
< 0.01), and CEUS carotid wall enhancement was more frequently (100% vs. 36.6%,
p
< 0.01) seen in TAK patients in the active phase than in those in the inactive phase. With increasing CEUS grades, both the artery wall thickness and ESR increased, and patients were more likely to be in the active phase (0 in grade 0, 42.9% in grade 1, and 75% in grade 2). Receiver operating characteristic (ROC) curve analysis showed that CEUS had an area under the ROC curve (AUC) of 0.872 (95% CI 0.785–0.959,
p
< 0.01), demonstrating good diagnostic accuracy.
Conclusions
Higher CEUS grades reliably identify patients with active TAK.
Key Points
•
No CEUS vascularization is obviously relative with the inactive disease of TAK patients.
•
Obvious CEUS vascularization is obviously relative with the active disease of TAK patients.</abstract><cop>London</cop><pub>Springer London</pub><pmid>31428886</pmid><doi>10.1007/s10067-019-04698-9</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Arteritis Carotid Arteries - diagnostic imaging Carotid Arteries - pathology Carotid artery Contrast Media Disease Progression Erythrocyte sedimentation rate Female Humans Male Medicine Medicine & Public Health Neovascularization, Pathologic - diagnosis Neovascularization, Pathologic - diagnostic imaging Original Article Rheumatology ROC Curve Takayasu Arteritis - diagnosis Takayasu Arteritis - diagnostic imaging Takayasu's disease Ultrasonic imaging Ultrasonography - methods Ultrasound Vascularization Vein & artery diseases Young Adult |
| title | Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients |
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