Changes in Thyroid Function Across Adolescence: A Longitudinal Study

Abstract Objective There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in thyrotropin (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and determine age-specific reference ranges. Methods Thyroid funct...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-04, Vol.105 (4), p.e1162-e1170
Hauptverfasser:	Campbell, Purdey J, Brown, Suzanne J, Kendrew, Phillip, Lewer, Michelle, Lim, Ee Mun, Joseph, John, Cross, Simone M, Wright, Margaret J, Martin, Nicholas G, Wilson, Scott G, Walsh, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescent Adolescents Age Biomarkers - blood Body mass index Child Child development Children & youth Female Follow-Up Studies Humans Longitudinal Studies Male Prognosis Puberty Reference Values Sex Factors Sexual dimorphism Thyroid Function Tests Thyroid gland Thyroid Gland - physiology Thyroid hormones Thyroid Hormones - blood Thyroid-stimulating hormone Thyroxine Triiodothyronine
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Zusammenfassung:	Abstract Objective There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in thyrotropin (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and determine age-specific reference ranges. Methods Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at ages 12, 14, and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. Results In girls, mean fT4 (± SE) increased between age 12 and 14 (by 0.30 ± 0.08 pmol/L; P
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgz331