Systemic and brain delivery of leptin via intranasal coadministration with cell-penetrating peptides and its therapeutic potential for obesity

Leptin is an endogenous hormone that regulates the appetite, energy metabolism, and glucose intake in the central nervous system (CNS) and is a potential therapeutic agent for obesity. In the normal healthy condition, peripherally secreted leptin is transported across the blood-brain barrier (BBB) t...

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Veröffentlicht in:	Journal of controlled release 2020-03, Vol.319, p.397-406
Hauptverfasser:	Khafagy, El-Sayed, Kamei, Noriyasu, Fujiwara, Yui, Okumura, Haruka, Yuasa, Teruyo, Kato, Masahiro, Arime, Kenji, Nonomura, Anna, Ogino, Hideyuki, Hirano, Serena, Sugano, Sayaka, Takeda-Morishita, Mariko
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain delivery Cell-penetrating peptide Intranasal administration Leptin Obesity
Online-Zugang:	Volltext
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