Reductase of Mutanobactin Synthetase Triggers Sequential C–C Macrocyclization, C–S Bond Formation, and C–C Bond Cleavage

Mutanobactins (MUBs) and their congeners that contain a macrocycle and/or a thiazepane ring are lipopeptides from Streptococcus mutans, a major causative agent of dental caries. Here we show that the C-terminal reductase domain of MubD releases the lipohexapeptide intermediates in an aldehyde form,...

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Veröffentlicht in:	Organic letters 2020-02, Vol.22 (3), p.960-964
Hauptverfasser:	Wang, Min, Xie, Zhoujie, Tang, Shoubin, Chang, Ee Ling, Tang, Yue, Guo, Zhengyan, Cui, Yinglu, Wu, Bian, Ye, Tao, Chen, Yihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclization Lipopeptides - biosynthesis Lipopeptides - chemistry Molecular Structure Oxidoreductases - chemistry Oxidoreductases - metabolism Peptides, Cyclic - biosynthesis Peptides, Cyclic - chemistry Stereoisomerism
Online-Zugang:	Volltext
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