The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio
Purpose This study aimed at investigating the association of severity of obstructive sleep apnea with the markers of inflammation as fibrinogen to albumin ratio and C-reactive protein to albumin ratio. Methods We included 126 patients admitted to sleep disorders outpatient clinic. We constituted fou...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2021-03, Vol.278 (3), p.851-855 |
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| container_title | European archives of oto-rhino-laryngology |
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| creator | Hizli, Omer Cayir, Serkan Coluk, Yonca Kayabasi, Serkan Yildirim, Guven |
| description | Purpose
This study aimed at investigating the association of severity of obstructive sleep apnea with the markers of inflammation as fibrinogen to albumin ratio and C-reactive protein to albumin ratio.
Methods
We included 126 patients admitted to sleep disorders outpatient clinic. We constituted four groups by reference to the apnea–hypopnea index (mild-moderate-severe sleep apnea and control group). We investigated the difference of white blood cell, fibrinogen to albumin ratio, C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin among the groups.
Results
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin did not significantly differ among four groups (
p
= 0.39,
p
= 0.06, and
p
= 0.31, respectively). A significant difference of fibrinogen to albumin ratio and C-reactive protein to albumin ratio was evident among four groups (
p
|
| doi_str_mv | 10.1007/s00405-019-05770-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2336246353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336246353</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-1d0c0db710779af7358652da69f831b10a0116ad79345c45bdbc46806e5762e73</originalsourceid><addsrcrecordid>eNp9kEtLw0AUhQdRbK3-ARcySzepdzKvxp0UXyAoUtfDJLmpKclMnUkK_ntTW90Iru7ifOfA_Qg5ZzBlAPoqAgiQCbAsAak1JPKAjJngIhE6VYdkDBnXiRBaj8hJjCsAkCLjx2TEWcYyqcSYNIt3pM5vsKG1K-vCdj5E6iva-hKD7ZB2nkbcYEAaG8Q1tWuH9ppWdR5q55fotoRt8r6tHR0ataebOKXz15c_wSk5qmwT8Wx_J-Tt7nYxf0ienu8f5zdPScGF7hJWQgFlrhlondlKczlTMi2tyqoZZzkDC4wpW-qMC1kImZd5IdQMFEqtUtR8Qi53u-vgP3qMnWnrWGDTWIe-jyblXKVCcckHNN2hRfAxBqzMOtStDZ-GgdlaNjvLZrBsvi0bOZQu9vt93mL5W_nROgB8B8QhcksMZuX74Iaf_5v9AoL3h1E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2336246353</pqid></control><display><type>article</type><title>The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hizli, Omer ; Cayir, Serkan ; Coluk, Yonca ; Kayabasi, Serkan ; Yildirim, Guven</creator><creatorcontrib>Hizli, Omer ; Cayir, Serkan ; Coluk, Yonca ; Kayabasi, Serkan ; Yildirim, Guven</creatorcontrib><description>Purpose
This study aimed at investigating the association of severity of obstructive sleep apnea with the markers of inflammation as fibrinogen to albumin ratio and C-reactive protein to albumin ratio.
Methods
We included 126 patients admitted to sleep disorders outpatient clinic. We constituted four groups by reference to the apnea–hypopnea index (mild-moderate-severe sleep apnea and control group). We investigated the difference of white blood cell, fibrinogen to albumin ratio, C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin among the groups.
Results
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin did not significantly differ among four groups (
p
= 0.39,
p
= 0.06, and
p
= 0.31, respectively). A significant difference of fibrinogen to albumin ratio and C-reactive protein to albumin ratio was evident among four groups (
p
< 0.001). Fibrinogen to albumin ratio and C-reactive protein to albumin ratio did not significantly differ between the mild sleep apnea and control groups (
p
= 0.65, and
p
= 0.85, respectively), but were significantly greater in moderate sleep apnea group compared with the control group (
p
< 0.001 and
p
= 0.001, respectively). Also, fibrinogen to albumin ratio and C-reactive protein to albumin ratio were significantly greater in the severe sleep apnea group compared with the control group (
p
< 0.001). Fibrinogen to albumin ratio and C-reactive protein to albumin ratio did not significantly differ between the severe sleep apnea and moderate sleep apnea groups (
p
= 0.49, and
p
= 0.58, respectively).
Conclusion
Higher fibrinogen to albumin ratio and C-reactive protein to albumin ratio may be predictive of inflammation in patients with moderate-to-severe sleep apnea.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-019-05770-5</identifier><identifier>PMID: 31919564</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Albumins ; C-Reactive Protein ; Fibrinogen ; Head and Neck ; Head and Neck Surgery ; Humans ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Sleep Apnea Syndrome: From the pathogenesis to the last therapies ; Sleep Apnea Syndromes</subject><ispartof>European archives of oto-rhino-laryngology, 2021-03, Vol.278 (3), p.851-855</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-1d0c0db710779af7358652da69f831b10a0116ad79345c45bdbc46806e5762e73</citedby><cites>FETCH-LOGICAL-c347t-1d0c0db710779af7358652da69f831b10a0116ad79345c45bdbc46806e5762e73</cites><orcidid>0000-0002-5969-4321 ; 0000-0003-4663-6293 ; 0000-0001-6822-2679 ; 0000-0003-3864-3522 ; 0000-0002-5292-5940</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-019-05770-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-019-05770-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31919564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hizli, Omer</creatorcontrib><creatorcontrib>Cayir, Serkan</creatorcontrib><creatorcontrib>Coluk, Yonca</creatorcontrib><creatorcontrib>Kayabasi, Serkan</creatorcontrib><creatorcontrib>Yildirim, Guven</creatorcontrib><title>The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
This study aimed at investigating the association of severity of obstructive sleep apnea with the markers of inflammation as fibrinogen to albumin ratio and C-reactive protein to albumin ratio.
Methods
We included 126 patients admitted to sleep disorders outpatient clinic. We constituted four groups by reference to the apnea–hypopnea index (mild-moderate-severe sleep apnea and control group). We investigated the difference of white blood cell, fibrinogen to albumin ratio, C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin among the groups.
Results
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin did not significantly differ among four groups (
p
= 0.39,
p
= 0.06, and
p
= 0.31, respectively). A significant difference of fibrinogen to albumin ratio and C-reactive protein to albumin ratio was evident among four groups (
p
< 0.001). Fibrinogen to albumin ratio and C-reactive protein to albumin ratio did not significantly differ between the mild sleep apnea and control groups (
p
= 0.65, and
p
= 0.85, respectively), but were significantly greater in moderate sleep apnea group compared with the control group (
p
< 0.001 and
p
= 0.001, respectively). Also, fibrinogen to albumin ratio and C-reactive protein to albumin ratio were significantly greater in the severe sleep apnea group compared with the control group (
p
< 0.001). Fibrinogen to albumin ratio and C-reactive protein to albumin ratio did not significantly differ between the severe sleep apnea and moderate sleep apnea groups (
p
= 0.49, and
p
= 0.58, respectively).
Conclusion
Higher fibrinogen to albumin ratio and C-reactive protein to albumin ratio may be predictive of inflammation in patients with moderate-to-severe sleep apnea.</description><subject>Albumins</subject><subject>C-Reactive Protein</subject><subject>Fibrinogen</subject><subject>Head and Neck</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Sleep Apnea Syndrome: From the pathogenesis to the last therapies</subject><subject>Sleep Apnea Syndromes</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK3-ARcySzepdzKvxp0UXyAoUtfDJLmpKclMnUkK_ntTW90Iru7ifOfA_Qg5ZzBlAPoqAgiQCbAsAak1JPKAjJngIhE6VYdkDBnXiRBaj8hJjCsAkCLjx2TEWcYyqcSYNIt3pM5vsKG1K-vCdj5E6iva-hKD7ZB2nkbcYEAaG8Q1tWuH9ppWdR5q55fotoRt8r6tHR0ataebOKXz15c_wSk5qmwT8Wx_J-Tt7nYxf0ienu8f5zdPScGF7hJWQgFlrhlondlKczlTMi2tyqoZZzkDC4wpW-qMC1kImZd5IdQMFEqtUtR8Qi53u-vgP3qMnWnrWGDTWIe-jyblXKVCcckHNN2hRfAxBqzMOtStDZ-GgdlaNjvLZrBsvi0bOZQu9vt93mL5W_nROgB8B8QhcksMZuX74Iaf_5v9AoL3h1E</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Hizli, Omer</creator><creator>Cayir, Serkan</creator><creator>Coluk, Yonca</creator><creator>Kayabasi, Serkan</creator><creator>Yildirim, Guven</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5969-4321</orcidid><orcidid>https://orcid.org/0000-0003-4663-6293</orcidid><orcidid>https://orcid.org/0000-0001-6822-2679</orcidid><orcidid>https://orcid.org/0000-0003-3864-3522</orcidid><orcidid>https://orcid.org/0000-0002-5292-5940</orcidid></search><sort><creationdate>20210301</creationdate><title>The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio</title><author>Hizli, Omer ; Cayir, Serkan ; Coluk, Yonca ; Kayabasi, Serkan ; Yildirim, Guven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-1d0c0db710779af7358652da69f831b10a0116ad79345c45bdbc46806e5762e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Albumins</topic><topic>C-Reactive Protein</topic><topic>Fibrinogen</topic><topic>Head and Neck</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Sleep Apnea Syndrome: From the pathogenesis to the last therapies</topic><topic>Sleep Apnea Syndromes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hizli, Omer</creatorcontrib><creatorcontrib>Cayir, Serkan</creatorcontrib><creatorcontrib>Coluk, Yonca</creatorcontrib><creatorcontrib>Kayabasi, Serkan</creatorcontrib><creatorcontrib>Yildirim, Guven</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hizli, Omer</au><au>Cayir, Serkan</au><au>Coluk, Yonca</au><au>Kayabasi, Serkan</au><au>Yildirim, Guven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>278</volume><issue>3</issue><spage>851</spage><epage>855</epage><pages>851-855</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
This study aimed at investigating the association of severity of obstructive sleep apnea with the markers of inflammation as fibrinogen to albumin ratio and C-reactive protein to albumin ratio.
Methods
We included 126 patients admitted to sleep disorders outpatient clinic. We constituted four groups by reference to the apnea–hypopnea index (mild-moderate-severe sleep apnea and control group). We investigated the difference of white blood cell, fibrinogen to albumin ratio, C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin among the groups.
Results
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and hemoglobin did not significantly differ among four groups (
p
= 0.39,
p
= 0.06, and
p
= 0.31, respectively). A significant difference of fibrinogen to albumin ratio and C-reactive protein to albumin ratio was evident among four groups (
p
< 0.001). Fibrinogen to albumin ratio and C-reactive protein to albumin ratio did not significantly differ between the mild sleep apnea and control groups (
p
= 0.65, and
p
= 0.85, respectively), but were significantly greater in moderate sleep apnea group compared with the control group (
p
< 0.001 and
p
= 0.001, respectively). Also, fibrinogen to albumin ratio and C-reactive protein to albumin ratio were significantly greater in the severe sleep apnea group compared with the control group (
p
< 0.001). Fibrinogen to albumin ratio and C-reactive protein to albumin ratio did not significantly differ between the severe sleep apnea and moderate sleep apnea groups (
p
= 0.49, and
p
= 0.58, respectively).
Conclusion
Higher fibrinogen to albumin ratio and C-reactive protein to albumin ratio may be predictive of inflammation in patients with moderate-to-severe sleep apnea.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31919564</pmid><doi>10.1007/s00405-019-05770-5</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5969-4321</orcidid><orcidid>https://orcid.org/0000-0003-4663-6293</orcidid><orcidid>https://orcid.org/0000-0001-6822-2679</orcidid><orcidid>https://orcid.org/0000-0003-3864-3522</orcidid><orcidid>https://orcid.org/0000-0002-5292-5940</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 2021-03, Vol.278 (3), p.851-855 |
| issn | 0937-4477 1434-4726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2336246353 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Albumins C-Reactive Protein Fibrinogen Head and Neck Head and Neck Surgery Humans Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Sleep Apnea Syndrome: From the pathogenesis to the last therapies Sleep Apnea Syndromes |
| title | The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio |
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