Modification of neutralizing epitopes of hemagglutinin for the development of broadly protective H9N2 vaccine

•Modification of major neutralizing epitopes of Hemagglutinin (HA) for broad protection against distinct H9N2 viruses.•We displayed modified HA on the baculovirus envelope (BacHAm).•Evaluated Bac-HAm vaccine constructs efficacy against H9N2 viruses in a mouse model.•Cross-protective efficacy of BacH...

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Veröffentlicht in:	Vaccine 2020-02, Vol.38 (6), p.1286-1290
Hauptverfasser:	Poh, Zhong Wee, Wang, Zhenzhang, Kumar, Subaschandrabose Rajesh, Yong, Hui Yee, Prabakaran, Mookkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies, Viral - immunology Antigenic drift Antigens Avian flu Baculoviral display HA Baculovirus Chickens Cross Protection Economic impact Epitopes Epitopes - genetics Epitopes - immunology H9N2 Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinins Immunization Immunoglobulins Infections Influenza Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Influenza in Birds - prevention & control Influenza Vaccines - genetics Influenza Vaccines - immunology Mice Monovalent vaccine strain Mutagenesis Mutants Mutation Neutralizing Neutralizing epitope Orthomyxoviridae Infections - prevention & control Pandemics Poultry Vaccine efficacy Vaccines Viruses
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