Gastroenteropancreatic neuroendocrine neoplasms and inflammation: A complex cross-talk with relevant clinical implications
Neuroendocrine neoplasms (NENs) are a group of tumors originating from the neuroendocrine system. They mainly occur in the digestive system and the respiratory tract. It is well-know a strict interaction between neuroendocrine system and inflammation, which can play an important role in NEN carcinog...
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| Veröffentlicht in: | Critical reviews in oncology/hematology 2020-02, Vol.146, p.102840-102840, Article 102840 |
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| container_title | Critical reviews in oncology/hematology |
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| creator | Vitale, Giovanni Carra, Silvia Ferraù, Francesco Guadagno, Elia Faggiano, Antongiulio Colao, Annamaria |
| description | Neuroendocrine neoplasms (NENs) are a group of tumors originating from the neuroendocrine system. They mainly occur in the digestive system and the respiratory tract. It is well-know a strict interaction between neuroendocrine system and inflammation, which can play an important role in NEN carcinogenesis. Inflammatory mediators, which are produced by the tumor microenvironment, can favor cancer induction and progression, and can promote immune editing. On the other hand, a balanced immune system represents a relevant step in cancer prevention through the elimination of dysplastic and cancer cells. Therefore, an inflammatory response may be both pro- and anti-tumorigenic. In this review, we provide an overview concerning the complex interplay between inflammation and gastroenteropancreatic NENs, focusing on the tumorigenesis and clinical implications in these tumors. |
| doi_str_mv | 10.1016/j.critrevonc.2019.102840 |
| format | Article |
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| subjects | Cytokines Cytokines - metabolism Gastrointestinal Neoplasms - immunology Gastrointestinal Neoplasms - pathology Humans Immune system Inflammation Inflammation - immunology Inflammation - metabolism Inflammation Mediators - immunology Inflammation Mediators - metabolism Intestinal Neoplasms - immunology Intestinal Neoplasms - pathology Neuroendocrine tumors Neuroendocrine Tumors - immunology Neuroendocrine Tumors - pathology Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Stomach Neoplasms - immunology Stomach Neoplasms - pathology Tumor Microenvironment |
| title | Gastroenteropancreatic neuroendocrine neoplasms and inflammation: A complex cross-talk with relevant clinical implications |
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