Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors

Solid tumors, especially desmoplastic tumors, are characterized by a dense fibrotic stroma composed of abundant cancer-associated fibroblasts and excessive extracellular matrix. These physical barriers seriously compromise drug delivery to tumor cells, leading to suboptimal treatment efficacy and re...

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Veröffentlicht in:	Biomaterials 2020-02, Vol.232, p.119745-119745, Article 119745
Hauptverfasser:	Han, Xuexiang, Xu, Ying, Geranpayehvaghei, Marzieh, Anderson, Gregory J., Li, Yiye, Nie, Guangjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-stromal therapy Antineoplastic Agents - therapeutic use Cancer-associated fibroblast Desmoplastic tumor Drug delivery Drug Delivery Systems Humans Immunotherapy Nanomedicine Neoplasms - drug therapy
Online-Zugang:	Volltext
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