Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the...

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Veröffentlicht in:	Immunology and cell biology 2020-03, Vol.98 (3), p.203-214
Hauptverfasser:	Zhan, Yifan, Kong, Isabella, Chopin, Michael, Macri, Christophe, Zhang, Jian‐Guo, Xie, Jiaying, Nutt, Stephen L, O'Keeffe, Meredith, Hawkins, Edwin D, Morand, Eric F, Lew, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autoimmunity CD4 antigen CD8 antigen Cell proliferation Dendritic cells Interferon Lupus Lymphocytes T Pathogenesis plasmacytoid dendritic cells Systemic lupus erythematosus α-Interferon
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