Immortalization of porcine hepatocytes with a α‐1,3‐galactosyltransferase knockout background

Background In vivo pig liver xenotransplantation preclinical trials appear to have poor efficiency compared to heart or kidney xenotransplantation because of xenogeneic rejection, including coagulopathy, and particularly thrombocytopenia. In contrast, ex vivo pig liver (wild type) perfusion systems...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2020-01, Vol.27 (1), p.e12550-n/a
Hauptverfasser:	Wang, Quancheng, Zhang, Xuan, Wang, Bo, Bai, Ge, Pan, Dengke, Yang, Peijun, Tao, Kaishan, Li, Xiao, Dou, Kefeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Apoptosis Biochemical analysis Blood circulation Blood Coagulation Disorders - immunology Carcinogenesis CD59 antigen Cell death Cell Line, Transformed Cell lines Cells, Cultured Cholecystokinin Clinical trials Cytotoxicity Enzyme-linked immunosorbent assay Flow cytometry Gene Knockout Techniques Glycogen Graft rejection Graft Rejection - immunology Graft Survival Heart Hepatocytes Hepatocytes - physiology Humans Immortalization Immune response Immunofluorescence Kidneys Liver Liver diseases Liver Transplantation Perfusion porcine hepatocyte Stem cell transplantation SV40T antigen Swine Thrombocytopenia Transplantation, Heterologous UDPglucose-Hexose-1-Phosphate Uridylyltransferase - genetics Xenografts α‐1,3‐galactosyltransferase knockout
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