Redundant role of ASK1-mediated p38MAPK activation in human platelet function

Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family, which recently has been implicated in the regulation of p38 MAPK/PLA2/thromboxane (TxA2) generation, as well as P2Y12 signalling in murine platelets. ASK1 has therefore been prop...

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Veröffentlicht in:	Cellular signalling 2020-04, Vol.68, p.109528-109528, Article 109528
Hauptverfasser:	Sledz, Kamila M., Moore, Samantha F., Vijayaragavan, Vijayasameerah, Mallah, Shahida, Goudswaard, Lucy J., Williams, Christopher M., Hunter, Roger W., Hers, Ingeborg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - drug effects Blood Platelets - enzymology C-Reactive Protein - metabolism Collagen - pharmacology Enzyme Activation - drug effects Humans MAP Kinase Kinase Kinase 5 - metabolism MAP Kinase Signaling System - drug effects Mice Models, Biological p38 Mitogen-Activated Protein Kinases - metabolism Phospholipases A2 - metabolism Phosphorylation - drug effects Platelet Aggregation - drug effects Platelet Membrane Glycoproteins - metabolism Thromboxane A2 - metabolism
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