Fam20C‐mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis

Osteopontin (OPN) is a phosphoglycoprotein secreted into the extracellular matrix upon liver injury, acting as a cytokine stimulates the deposition of fibrillary collagen in liver fibrogenesis. In livers of mice subjected to bile duct ligation (BDL) and in cultured activated hepatic stellate cells (...

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Veröffentlicht in:	The FASEB journal 2020-01, Vol.34 (1), p.1122-1135
Hauptverfasser:	Tibaldi, Elena, Brocca, Alessandra, Sticca, Antonietta, Gola, Elisabetta, Pizzi, Marco, Bordin, Luciana, Pagano, Mario Angelo, Mazzorana, Marco, Donà, Gabriella, Violi, Paola, Marin, Oriano, Romano, Antonella, Angeli, Paolo, Carraro, Amedeo, Brunati, Anna Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	bile duct ligation Golgi apparatus hepatic stellate cells osteopontin phosphorylation
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