Configuration design and correction ability evaluation of a novel external fixator for foot and ankle deformity treated by U osteotomy

As a basic osteotomy technique, U osteotomy can be applied for certain complex foot and ankle deformities. Gradual correction cases using Ilizarov apparatus and Taylor Spatial Frame have been reported. This paper proposes a novel parallel distraction apparatus for U osteotomy (PDA-Uos) to supplement...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Medical & biological engineering & computing 2020-03, Vol.58 (3), p.541-558
Hauptverfasser: Zuo, Shiping, Dong, Mingjie, Li, Jianfeng, Tao, Chunjing, Ji, Run
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 558
container_issue 3
container_start_page 541
container_title Medical & biological engineering & computing
container_volume 58
creator Zuo, Shiping
Dong, Mingjie
Li, Jianfeng
Tao, Chunjing
Ji, Run
description As a basic osteotomy technique, U osteotomy can be applied for certain complex foot and ankle deformities. Gradual correction cases using Ilizarov apparatus and Taylor Spatial Frame have been reported. This paper proposes a novel parallel distraction apparatus for U osteotomy (PDA-Uos) to supplement the correction equipment for surgeon. Designed with an adjustable structure, the PDA-Uos can adopt different assembly shapes (joint connection points). However, the influence of the change in assembly shape on interference-free workspace and self-structural performance of the external fixator have received little attention. To address this issue and enhance the selection of the most suitable assembly shape for patient, an algorithm to obtain the interference-free workspace of different assembly shapes is proposed based on the inverse position solution of the PDA-Uos. Additionally, correction ability indices are defined according to the requirements of accurately controlled motion and high structural stiffness of the external fixator along the correction path. The results of simulation cases indicate that the interference-free workspace and the correction ability vary according to the assembly shape and thus the proposed method can be used to select an assembly shape with sufficient workspace and the best correction ability before performing correction for a given patient. Graphical abstract
doi_str_mv 10.1007/s11517-019-02103-w
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2335171297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2335171297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-3c851e65a27cc0d8bf9577ea15c61424dd11ba1138475c9d7a00b7705ea19a5b3</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi0EarelL8ABWeLCJdQT2-vNEa2AIlXi0p6tiTNZpSR2sZ22-wI8N95NAYkDB8vSzDffyP4ZewPiAwhhLhOABlMJaCpRg5DV4wu2AqOgEkqpl2wlQInShs0pO0vpThRK1-qEnUpoYC2MXrGf2-D7YTdHzEPwvKM07DxH33EXYiR3rGI7jEPec3rAcV7A0HPkPjzQyOkpU_Q48n54whwi748n5KMG_feRircUp4MjR8JMHW_3_JaHlCnkMO1fs1c9jokunu9zdvv50832qrr-9uXr9uN15aTRuZJuo4HWGmvjnOg2bd9oYwhBuzWoWnUdQIsAcqOMdk1nUIjWGKEL0qBu5Tl7v3jvY_gxU8p2GpKjcURPYU62lrJ8KdSNKei7f9C7MB_eeaBMvZaFlYWqF8rFkFKk3t7HYcK4tyDsISW7pGRLSvaYkn0sQ2-f1XM7Ufdn5HcsBZALkErL7yj-3f0f7S8w1J9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2372632333</pqid></control><display><type>article</type><title>Configuration design and correction ability evaluation of a novel external fixator for foot and ankle deformity treated by U osteotomy</title><source>MEDLINE</source><source>EBSCOhost Business Source Complete</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zuo, Shiping ; Dong, Mingjie ; Li, Jianfeng ; Tao, Chunjing ; Ji, Run</creator><creatorcontrib>Zuo, Shiping ; Dong, Mingjie ; Li, Jianfeng ; Tao, Chunjing ; Ji, Run</creatorcontrib><description>As a basic osteotomy technique, U osteotomy can be applied for certain complex foot and ankle deformities. Gradual correction cases using Ilizarov apparatus and Taylor Spatial Frame have been reported. This paper proposes a novel parallel distraction apparatus for U osteotomy (PDA-Uos) to supplement the correction equipment for surgeon. Designed with an adjustable structure, the PDA-Uos can adopt different assembly shapes (joint connection points). However, the influence of the change in assembly shape on interference-free workspace and self-structural performance of the external fixator have received little attention. To address this issue and enhance the selection of the most suitable assembly shape for patient, an algorithm to obtain the interference-free workspace of different assembly shapes is proposed based on the inverse position solution of the PDA-Uos. Additionally, correction ability indices are defined according to the requirements of accurately controlled motion and high structural stiffness of the external fixator along the correction path. The results of simulation cases indicate that the interference-free workspace and the correction ability vary according to the assembly shape and thus the proposed method can be used to select an assembly shape with sufficient workspace and the best correction ability before performing correction for a given patient. Graphical abstract</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/s11517-019-02103-w</identifier><identifier>PMID: 31916075</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Algorithms ; Ankle ; Ankle Joint - abnormalities ; Ankle Joint - surgery ; Assembly ; Biomechanical Phenomena ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Biomedicine ; Computer Applications ; Computer Simulation ; Configuration management ; Equipment Design ; External Fixators ; Feet ; Foot Deformities, Congenital - surgery ; Human Physiology ; Humans ; Imaging ; Interference ; Motion ; Original Article ; Osteotomy ; Osteotomy - instrumentation ; Radiology ; Stiffness</subject><ispartof>Medical &amp; biological engineering &amp; computing, 2020-03, Vol.58 (3), p.541-558</ispartof><rights>International Federation for Medical and Biological Engineering 2020</rights><rights>Medical and Biological Engineering and Computing is a copyright of Springer, (2020). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3c851e65a27cc0d8bf9577ea15c61424dd11ba1138475c9d7a00b7705ea19a5b3</citedby><cites>FETCH-LOGICAL-c375t-3c851e65a27cc0d8bf9577ea15c61424dd11ba1138475c9d7a00b7705ea19a5b3</cites><orcidid>0000-0002-4338-6420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11517-019-02103-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11517-019-02103-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31916075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zuo, Shiping</creatorcontrib><creatorcontrib>Dong, Mingjie</creatorcontrib><creatorcontrib>Li, Jianfeng</creatorcontrib><creatorcontrib>Tao, Chunjing</creatorcontrib><creatorcontrib>Ji, Run</creatorcontrib><title>Configuration design and correction ability evaluation of a novel external fixator for foot and ankle deformity treated by U osteotomy</title><title>Medical &amp; biological engineering &amp; computing</title><addtitle>Med Biol Eng Comput</addtitle><addtitle>Med Biol Eng Comput</addtitle><description>As a basic osteotomy technique, U osteotomy can be applied for certain complex foot and ankle deformities. Gradual correction cases using Ilizarov apparatus and Taylor Spatial Frame have been reported. This paper proposes a novel parallel distraction apparatus for U osteotomy (PDA-Uos) to supplement the correction equipment for surgeon. Designed with an adjustable structure, the PDA-Uos can adopt different assembly shapes (joint connection points). However, the influence of the change in assembly shape on interference-free workspace and self-structural performance of the external fixator have received little attention. To address this issue and enhance the selection of the most suitable assembly shape for patient, an algorithm to obtain the interference-free workspace of different assembly shapes is proposed based on the inverse position solution of the PDA-Uos. Additionally, correction ability indices are defined according to the requirements of accurately controlled motion and high structural stiffness of the external fixator along the correction path. The results of simulation cases indicate that the interference-free workspace and the correction ability vary according to the assembly shape and thus the proposed method can be used to select an assembly shape with sufficient workspace and the best correction ability before performing correction for a given patient. Graphical abstract</description><subject>Algorithms</subject><subject>Ankle</subject><subject>Ankle Joint - abnormalities</subject><subject>Ankle Joint - surgery</subject><subject>Assembly</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Computer Applications</subject><subject>Computer Simulation</subject><subject>Configuration management</subject><subject>Equipment Design</subject><subject>External Fixators</subject><subject>Feet</subject><subject>Foot Deformities, Congenital - surgery</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interference</subject><subject>Motion</subject><subject>Original Article</subject><subject>Osteotomy</subject><subject>Osteotomy - instrumentation</subject><subject>Radiology</subject><subject>Stiffness</subject><issn>0140-0118</issn><issn>1741-0444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFu1DAQhi0EarelL8ABWeLCJdQT2-vNEa2AIlXi0p6tiTNZpSR2sZ22-wI8N95NAYkDB8vSzDffyP4ZewPiAwhhLhOABlMJaCpRg5DV4wu2AqOgEkqpl2wlQInShs0pO0vpThRK1-qEnUpoYC2MXrGf2-D7YTdHzEPwvKM07DxH33EXYiR3rGI7jEPec3rAcV7A0HPkPjzQyOkpU_Q48n54whwi748n5KMG_feRircUp4MjR8JMHW_3_JaHlCnkMO1fs1c9jokunu9zdvv50832qrr-9uXr9uN15aTRuZJuo4HWGmvjnOg2bd9oYwhBuzWoWnUdQIsAcqOMdk1nUIjWGKEL0qBu5Tl7v3jvY_gxU8p2GpKjcURPYU62lrJ8KdSNKei7f9C7MB_eeaBMvZaFlYWqF8rFkFKk3t7HYcK4tyDsISW7pGRLSvaYkn0sQ2-f1XM7Ufdn5HcsBZALkErL7yj-3f0f7S8w1J9A</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Zuo, Shiping</creator><creator>Dong, Mingjie</creator><creator>Li, Jianfeng</creator><creator>Tao, Chunjing</creator><creator>Ji, Run</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7SC</scope><scope>7TB</scope><scope>7TS</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AL</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K60</scope><scope>K6~</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0C</scope><scope>M0N</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4338-6420</orcidid></search><sort><creationdate>20200301</creationdate><title>Configuration design and correction ability evaluation of a novel external fixator for foot and ankle deformity treated by U osteotomy</title><author>Zuo, Shiping ; Dong, Mingjie ; Li, Jianfeng ; Tao, Chunjing ; Ji, Run</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3c851e65a27cc0d8bf9577ea15c61424dd11ba1138475c9d7a00b7705ea19a5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algorithms</topic><topic>Ankle</topic><topic>Ankle Joint - abnormalities</topic><topic>Ankle Joint - surgery</topic><topic>Assembly</topic><topic>Biomechanical Phenomena</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Biomedicine</topic><topic>Computer Applications</topic><topic>Computer Simulation</topic><topic>Configuration management</topic><topic>Equipment Design</topic><topic>External Fixators</topic><topic>Feet</topic><topic>Foot Deformities, Congenital - surgery</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interference</topic><topic>Motion</topic><topic>Original Article</topic><topic>Osteotomy</topic><topic>Osteotomy - instrumentation</topic><topic>Radiology</topic><topic>Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuo, Shiping</creatorcontrib><creatorcontrib>Dong, Mingjie</creatorcontrib><creatorcontrib>Li, Jianfeng</creatorcontrib><creatorcontrib>Tao, Chunjing</creatorcontrib><creatorcontrib>Ji, Run</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing &amp; Allied Health Source</collection><collection>Computer and Information Systems Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Computing Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>ABI/INFORM Global</collection><collection>Computing Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Medical &amp; biological engineering &amp; computing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zuo, Shiping</au><au>Dong, Mingjie</au><au>Li, Jianfeng</au><au>Tao, Chunjing</au><au>Ji, Run</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Configuration design and correction ability evaluation of a novel external fixator for foot and ankle deformity treated by U osteotomy</atitle><jtitle>Medical &amp; biological engineering &amp; computing</jtitle><stitle>Med Biol Eng Comput</stitle><addtitle>Med Biol Eng Comput</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>58</volume><issue>3</issue><spage>541</spage><epage>558</epage><pages>541-558</pages><issn>0140-0118</issn><eissn>1741-0444</eissn><abstract>As a basic osteotomy technique, U osteotomy can be applied for certain complex foot and ankle deformities. Gradual correction cases using Ilizarov apparatus and Taylor Spatial Frame have been reported. This paper proposes a novel parallel distraction apparatus for U osteotomy (PDA-Uos) to supplement the correction equipment for surgeon. Designed with an adjustable structure, the PDA-Uos can adopt different assembly shapes (joint connection points). However, the influence of the change in assembly shape on interference-free workspace and self-structural performance of the external fixator have received little attention. To address this issue and enhance the selection of the most suitable assembly shape for patient, an algorithm to obtain the interference-free workspace of different assembly shapes is proposed based on the inverse position solution of the PDA-Uos. Additionally, correction ability indices are defined according to the requirements of accurately controlled motion and high structural stiffness of the external fixator along the correction path. The results of simulation cases indicate that the interference-free workspace and the correction ability vary according to the assembly shape and thus the proposed method can be used to select an assembly shape with sufficient workspace and the best correction ability before performing correction for a given patient. Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31916075</pmid><doi>10.1007/s11517-019-02103-w</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-4338-6420</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0140-0118
ispartof Medical & biological engineering & computing, 2020-03, Vol.58 (3), p.541-558
issn 0140-0118
1741-0444
language eng
recordid cdi_proquest_miscellaneous_2335171297
source MEDLINE; EBSCOhost Business Source Complete; SpringerLink Journals - AutoHoldings
subjects Algorithms
Ankle
Ankle Joint - abnormalities
Ankle Joint - surgery
Assembly
Biomechanical Phenomena
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedical materials
Biomedicine
Computer Applications
Computer Simulation
Configuration management
Equipment Design
External Fixators
Feet
Foot Deformities, Congenital - surgery
Human Physiology
Humans
Imaging
Interference
Motion
Original Article
Osteotomy
Osteotomy - instrumentation
Radiology
Stiffness
title Configuration design and correction ability evaluation of a novel external fixator for foot and ankle deformity treated by U osteotomy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T21%3A03%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Configuration%20design%20and%20correction%20ability%20evaluation%20of%20a%20novel%20external%20fixator%20for%20foot%20and%20ankle%20deformity%20treated%20by%20U%20osteotomy&rft.jtitle=Medical%20&%20biological%20engineering%20&%20computing&rft.au=Zuo,%20Shiping&rft.date=2020-03-01&rft.volume=58&rft.issue=3&rft.spage=541&rft.epage=558&rft.pages=541-558&rft.issn=0140-0118&rft.eissn=1741-0444&rft_id=info:doi/10.1007/s11517-019-02103-w&rft_dat=%3Cproquest_cross%3E2335171297%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2372632333&rft_id=info:pmid/31916075&rfr_iscdi=true