Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function
Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed characterization of the human heart is necessary; however, this has been largely impeded by the cellular diversity of cardiac tissue and limited access to samples. Here, we show transcriptome profiling of 21,422 si...
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| Veröffentlicht in: | Nature cell biology 2020-01, Vol.22 (1), p.108-119 |
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| creator | Wang, Li Yu, Peng Zhou, Bingying Song, Jiangping Li, Zheng Zhang, Mingzhi Guo, Guangran Wang, Yin Chen, Xiao Han, Leng Hu, Shengshou |
| description | Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed characterization of the human heart is necessary; however, this has been largely impeded by the cellular diversity of cardiac tissue and limited access to samples. Here, we show transcriptome profiling of 21,422 single cells—including cardiomyocytes (CMs) and non-CMs (NCMs)—from normal, failed and partially recovered (left ventricular assist device treatment) adult human hearts. Comparative analysis of atrial and ventricular cells revealed pronounced inter- and intracompartmental CM heterogeneity as well as compartment-specific utilization of NCM cell types as major cell-communication hubs. Systematic analysis of cellular compositions and cell–cell interaction networks showed that CM contractility and metabolism are the most prominent aspects that are correlated with changes in heart function. We also uncovered active engagement of NCMs in regulating the behaviour of CMs, exemplified by ACKR1
+
-endothelial cells, injection of which preserved cardiac function after injury. Beyond serving as a rich resource, our study provides insights into cell-type-targeted intervention of heart diseases.
Wang, Yu, Zhou, Song et al. profile cardiomyocytes and neighbouring cells from healthy adults and patients with heart failure and in recovery, and delineate their cellular compositions and interaction networks. |
| doi_str_mv | 10.1038/s41556-019-0446-7 |
| format | Article |
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+
-endothelial cells, injection of which preserved cardiac function after injury. Beyond serving as a rich resource, our study provides insights into cell-type-targeted intervention of heart diseases.
Wang, Yu, Zhou, Song et al. profile cardiomyocytes and neighbouring cells from healthy adults and patients with heart failure and in recovery, and delineate their cellular compositions and interaction networks.</description><identifier>ISSN: 1465-7392</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/s41556-019-0446-7</identifier><identifier>PMID: 31915373</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 45/91 ; 631/443/592 ; 64/60 ; 692/699/75/230 ; Biomedical and Life Sciences ; Cancer Research ; Cardiac function ; Cardiac patients ; Cardiomyocytes ; Cardiovascular diseases ; Cell Biology ; Cell Differentiation - physiology ; Cell interactions ; Cellular communication ; Comparative analysis ; Composition ; Congestive heart failure ; Coronary artery disease ; Developmental Biology ; Endothelial cells ; Endothelial Cells - metabolism ; Gene expression ; Gene Expression Profiling - methods ; Health aspects ; Heart ; Heart diseases ; Heart failure ; Heart Failure - metabolism ; Heart function ; Heart Ventricles - metabolism ; Heterogeneity ; Humans ; Life Sciences ; Mortality ; Muscle contraction ; Myocytes, Cardiac - metabolism ; Prevalence studies (Epidemiology) ; Recovery ; Resource ; Stem Cells ; Ventricle</subject><ispartof>Nature cell biology, 2020-01, Vol.22 (1), p.108-119</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>2020© The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-9ba53401376838d14c9c49987a160746d5342871761bacd607ada33322e76fbb3</citedby><cites>FETCH-LOGICAL-c539t-9ba53401376838d14c9c49987a160746d5342871761bacd607ada33322e76fbb3</cites><orcidid>0000-0002-7380-2640 ; 0000-0002-7473-6729 ; 0000-0002-5570-1336</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41556-019-0446-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41556-019-0446-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31915373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Yu, Peng</creatorcontrib><creatorcontrib>Zhou, Bingying</creatorcontrib><creatorcontrib>Song, Jiangping</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><creatorcontrib>Zhang, Mingzhi</creatorcontrib><creatorcontrib>Guo, Guangran</creatorcontrib><creatorcontrib>Wang, Yin</creatorcontrib><creatorcontrib>Chen, Xiao</creatorcontrib><creatorcontrib>Han, Leng</creatorcontrib><creatorcontrib>Hu, Shengshou</creatorcontrib><title>Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function</title><title>Nature cell biology</title><addtitle>Nat Cell Biol</addtitle><addtitle>Nat Cell Biol</addtitle><description>Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed characterization of the human heart is necessary; however, this has been largely impeded by the cellular diversity of cardiac tissue and limited access to samples. Here, we show transcriptome profiling of 21,422 single cells—including cardiomyocytes (CMs) and non-CMs (NCMs)—from normal, failed and partially recovered (left ventricular assist device treatment) adult human hearts. Comparative analysis of atrial and ventricular cells revealed pronounced inter- and intracompartmental CM heterogeneity as well as compartment-specific utilization of NCM cell types as major cell-communication hubs. Systematic analysis of cellular compositions and cell–cell interaction networks showed that CM contractility and metabolism are the most prominent aspects that are correlated with changes in heart function. We also uncovered active engagement of NCMs in regulating the behaviour of CMs, exemplified by ACKR1
+
-endothelial cells, injection of which preserved cardiac function after injury. Beyond serving as a rich resource, our study provides insights into cell-type-targeted intervention of heart diseases.
Wang, Yu, Zhou, Song et al. profile cardiomyocytes and neighbouring cells from healthy adults and patients with heart failure and in recovery, and delineate their cellular compositions and interaction networks.</description><subject>13/51</subject><subject>45/91</subject><subject>631/443/592</subject><subject>64/60</subject><subject>692/699/75/230</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Cardiac function</subject><subject>Cardiac patients</subject><subject>Cardiomyocytes</subject><subject>Cardiovascular diseases</subject><subject>Cell Biology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell interactions</subject><subject>Cellular communication</subject><subject>Comparative analysis</subject><subject>Composition</subject><subject>Congestive heart failure</subject><subject>Coronary artery disease</subject><subject>Developmental Biology</subject><subject>Endothelial cells</subject><subject>Endothelial Cells - 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Academic</collection><jtitle>Nature cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Li</au><au>Yu, Peng</au><au>Zhou, Bingying</au><au>Song, Jiangping</au><au>Li, Zheng</au><au>Zhang, Mingzhi</au><au>Guo, Guangran</au><au>Wang, Yin</au><au>Chen, Xiao</au><au>Han, Leng</au><au>Hu, Shengshou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>22</volume><issue>1</issue><spage>108</spage><epage>119</epage><pages>108-119</pages><issn>1465-7392</issn><eissn>1476-4679</eissn><abstract>Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed characterization of the human heart is necessary; however, this has been largely impeded by the cellular diversity of cardiac tissue and limited access to samples. Here, we show transcriptome profiling of 21,422 single cells—including cardiomyocytes (CMs) and non-CMs (NCMs)—from normal, failed and partially recovered (left ventricular assist device treatment) adult human hearts. Comparative analysis of atrial and ventricular cells revealed pronounced inter- and intracompartmental CM heterogeneity as well as compartment-specific utilization of NCM cell types as major cell-communication hubs. Systematic analysis of cellular compositions and cell–cell interaction networks showed that CM contractility and metabolism are the most prominent aspects that are correlated with changes in heart function. We also uncovered active engagement of NCMs in regulating the behaviour of CMs, exemplified by ACKR1
+
-endothelial cells, injection of which preserved cardiac function after injury. Beyond serving as a rich resource, our study provides insights into cell-type-targeted intervention of heart diseases.
Wang, Yu, Zhou, Song et al. profile cardiomyocytes and neighbouring cells from healthy adults and patients with heart failure and in recovery, and delineate their cellular compositions and interaction networks.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31915373</pmid><doi>10.1038/s41556-019-0446-7</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7380-2640</orcidid><orcidid>https://orcid.org/0000-0002-7473-6729</orcidid><orcidid>https://orcid.org/0000-0002-5570-1336</orcidid></addata></record> |
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| subjects | 13/51 45/91 631/443/592 64/60 692/699/75/230 Biomedical and Life Sciences Cancer Research Cardiac function Cardiac patients Cardiomyocytes Cardiovascular diseases Cell Biology Cell Differentiation - physiology Cell interactions Cellular communication Comparative analysis Composition Congestive heart failure Coronary artery disease Developmental Biology Endothelial cells Endothelial Cells - metabolism Gene expression Gene Expression Profiling - methods Health aspects Heart Heart diseases Heart failure Heart Failure - metabolism Heart function Heart Ventricles - metabolism Heterogeneity Humans Life Sciences Mortality Muscle contraction Myocytes, Cardiac - metabolism Prevalence studies (Epidemiology) Recovery Resource Stem Cells Ventricle |
| title | Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function |
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