Clinical characteristics and biomarkers analysis of asthma inflammatory phenotypes
Asthma inflammatory phenotypes facilitate treatment, their clinical characteristics and biomarkers were analyzed. A total of 176 asthmatics were divided into eosinophilic asthma (EA), neutrophilic asthma (NA), paucigranulocytic asthma and mixed-granulocytic asthma by induced sputum. EA, NA and pauci...
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| Veröffentlicht in: | Biomarkers in medicine 2020-02, Vol.14 (3), p.211-222 |
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| creator | Gao, Wei Han, Guo-Jing Zhu, Yu-Jin Mao, Dan Hu, Hong |
| description | Asthma inflammatory phenotypes facilitate treatment, their clinical characteristics and biomarkers were analyzed.
A total of 176 asthmatics were divided into eosinophilic asthma (EA), neutrophilic asthma (NA), paucigranulocytic asthma and mixed-granulocytic asthma by induced sputum.
EA, NA and paucigranulocytic asthma patients were 65 (36.9%), 31 (17.6%) and 75 (42.6%). Sputum IL-5 and IL-13, blood IL-13, fractional exhaled nitric oxide (FeNO) were related to EA, the areas under the receiver operating characteristic curve were 0.790, 0.846, 0.828, 0.830, combined FeNO with blood IL-13 was 0.872. Sputum and blood IL-8, blood IL-17 were related to NA, their area under the receiver operating characteristic curve was 0.939, 0.844, 0.821, combined blood IL-8 with IL-17 was 0.882.
Blood IL-13 and FeNO, blood IL-8 and IL-17 were alternative biomarkers of EA and NA, respectively. |
| doi_str_mv | 10.2217/bmm-2019-0487 |
| format | Article |
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A total of 176 asthmatics were divided into eosinophilic asthma (EA), neutrophilic asthma (NA), paucigranulocytic asthma and mixed-granulocytic asthma by induced sputum.
EA, NA and paucigranulocytic asthma patients were 65 (36.9%), 31 (17.6%) and 75 (42.6%). Sputum IL-5 and IL-13, blood IL-13, fractional exhaled nitric oxide (FeNO) were related to EA, the areas under the receiver operating characteristic curve were 0.790, 0.846, 0.828, 0.830, combined FeNO with blood IL-13 was 0.872. Sputum and blood IL-8, blood IL-17 were related to NA, their area under the receiver operating characteristic curve was 0.939, 0.844, 0.821, combined blood IL-8 with IL-17 was 0.882.
Blood IL-13 and FeNO, blood IL-8 and IL-17 were alternative biomarkers of EA and NA, respectively.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2019-0487</identifier><identifier>PMID: 31910648</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Asthma ; asthma inflammatory phenotypes ; Biomarkers ; Blood ; Blood tests ; Cytokines ; Disease ; eosinophils ; FeNO ; IL-13 ; IL-17 ; IL-5 ; IL-8 ; induced sputum ; Infections ; Inflammation ; Interleukin 13 ; Interleukin 17 ; Interleukin 5 ; Interleukin 8 ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Neutrophils ; Nitric oxide ; Phenotypes ; Physiology ; Questionnaires ; Spirometry ; Sputum</subject><ispartof>Biomarkers in medicine, 2020-02, Vol.14 (3), p.211-222</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Feb 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-1b0fe792ead0735210b3480489f6e088587339c65e8f5e410cd546df66bcaa643</citedby><cites>FETCH-LOGICAL-c371t-1b0fe792ead0735210b3480489f6e088587339c65e8f5e410cd546df66bcaa643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31910648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Wei</creatorcontrib><creatorcontrib>Han, Guo-Jing</creatorcontrib><creatorcontrib>Zhu, Yu-Jin</creatorcontrib><creatorcontrib>Mao, Dan</creatorcontrib><creatorcontrib>Hu, Hong</creatorcontrib><title>Clinical characteristics and biomarkers analysis of asthma inflammatory phenotypes</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>Asthma inflammatory phenotypes facilitate treatment, their clinical characteristics and biomarkers were analyzed.
A total of 176 asthmatics were divided into eosinophilic asthma (EA), neutrophilic asthma (NA), paucigranulocytic asthma and mixed-granulocytic asthma by induced sputum.
EA, NA and paucigranulocytic asthma patients were 65 (36.9%), 31 (17.6%) and 75 (42.6%). Sputum IL-5 and IL-13, blood IL-13, fractional exhaled nitric oxide (FeNO) were related to EA, the areas under the receiver operating characteristic curve were 0.790, 0.846, 0.828, 0.830, combined FeNO with blood IL-13 was 0.872. Sputum and blood IL-8, blood IL-17 were related to NA, their area under the receiver operating characteristic curve was 0.939, 0.844, 0.821, combined blood IL-8 with IL-17 was 0.882.
Blood IL-13 and FeNO, blood IL-8 and IL-17 were alternative biomarkers of EA and NA, respectively.</description><subject>Asthma</subject><subject>asthma inflammatory phenotypes</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood tests</subject><subject>Cytokines</subject><subject>Disease</subject><subject>eosinophils</subject><subject>FeNO</subject><subject>IL-13</subject><subject>IL-17</subject><subject>IL-5</subject><subject>IL-8</subject><subject>induced sputum</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interleukin 13</subject><subject>Interleukin 17</subject><subject>Interleukin 5</subject><subject>Interleukin 8</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Neutrophils</subject><subject>Nitric oxide</subject><subject>Phenotypes</subject><subject>Physiology</subject><subject>Questionnaires</subject><subject>Spirometry</subject><subject>Sputum</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLxDAURoMojo4u3UrBjZtqHm3SLGXwBQOC6Dqk6Q2TsS-TdjH_3pSOsxBc3Vw4-bjfQeiK4DtKibgvmyalmMgUZ4U4QmdE5DTFTJDjw5uzBToPYYtxLgSnp2jBiCSYZ8UZel_VrnVG14nZaK_NAN6FwZmQ6LZKStc12n-Bn1Zd74ILSWcTHYZNoxPX2lo3jR46v0v6DbTdsOshXKATq-sAl_u5RJ9Pjx-rl3T99vy6elinJl43pKTEFoSkoCssWE4JLllWxBbScsBFkReCMWl4DoXNISPYVHnGK8t5abTmGVui2zm39933CGFQjQsG6lq30I1BUcYyLiXHPKI3f9BtN_rYKFI5pkRGDkcqnSnjuxA8WNV7F_vvFMFqkq2ibDXJVpPsyF_vU8eygepA_9qNgJwBOw6jh2ActAbUvMUfzrgW_gn_ATO4jek</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Gao, Wei</creator><creator>Han, Guo-Jing</creator><creator>Zhu, Yu-Jin</creator><creator>Mao, Dan</creator><creator>Hu, Hong</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>Clinical characteristics and biomarkers analysis of asthma inflammatory phenotypes</title><author>Gao, Wei ; Han, Guo-Jing ; Zhu, Yu-Jin ; Mao, Dan ; Hu, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-1b0fe792ead0735210b3480489f6e088587339c65e8f5e410cd546df66bcaa643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Asthma</topic><topic>asthma inflammatory phenotypes</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood tests</topic><topic>Cytokines</topic><topic>Disease</topic><topic>eosinophils</topic><topic>FeNO</topic><topic>IL-13</topic><topic>IL-17</topic><topic>IL-5</topic><topic>IL-8</topic><topic>induced sputum</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Interleukin 13</topic><topic>Interleukin 17</topic><topic>Interleukin 5</topic><topic>Interleukin 8</topic><topic>Leukocytes (eosinophilic)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Neutrophils</topic><topic>Nitric oxide</topic><topic>Phenotypes</topic><topic>Physiology</topic><topic>Questionnaires</topic><topic>Spirometry</topic><topic>Sputum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Wei</creatorcontrib><creatorcontrib>Han, Guo-Jing</creatorcontrib><creatorcontrib>Zhu, Yu-Jin</creatorcontrib><creatorcontrib>Mao, Dan</creatorcontrib><creatorcontrib>Hu, Hong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Wei</au><au>Han, Guo-Jing</au><au>Zhu, Yu-Jin</au><au>Mao, Dan</au><au>Hu, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and biomarkers analysis of asthma inflammatory phenotypes</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>14</volume><issue>3</issue><spage>211</spage><epage>222</epage><pages>211-222</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>Asthma inflammatory phenotypes facilitate treatment, their clinical characteristics and biomarkers were analyzed.
A total of 176 asthmatics were divided into eosinophilic asthma (EA), neutrophilic asthma (NA), paucigranulocytic asthma and mixed-granulocytic asthma by induced sputum.
EA, NA and paucigranulocytic asthma patients were 65 (36.9%), 31 (17.6%) and 75 (42.6%). Sputum IL-5 and IL-13, blood IL-13, fractional exhaled nitric oxide (FeNO) were related to EA, the areas under the receiver operating characteristic curve were 0.790, 0.846, 0.828, 0.830, combined FeNO with blood IL-13 was 0.872. Sputum and blood IL-8, blood IL-17 were related to NA, their area under the receiver operating characteristic curve was 0.939, 0.844, 0.821, combined blood IL-8 with IL-17 was 0.882.
Blood IL-13 and FeNO, blood IL-8 and IL-17 were alternative biomarkers of EA and NA, respectively.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31910648</pmid><doi>10.2217/bmm-2019-0487</doi><tpages>12</tpages></addata></record> |
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| subjects | Asthma asthma inflammatory phenotypes Biomarkers Blood Blood tests Cytokines Disease eosinophils FeNO IL-13 IL-17 IL-5 IL-8 induced sputum Infections Inflammation Interleukin 13 Interleukin 17 Interleukin 5 Interleukin 8 Leukocytes (eosinophilic) Leukocytes (neutrophilic) Neutrophils Nitric oxide Phenotypes Physiology Questionnaires Spirometry Sputum |
| title | Clinical characteristics and biomarkers analysis of asthma inflammatory phenotypes |
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