A self-assembled DNA tetrahedron as a carrier for in vivo liver-specific delivery of siRNA

While siRNA is a potent therapeutic tool that can silence disease-causing mRNA, its in vivo potency can be compromised due to the lack of target tissue specificity. Here, we report a wireframe tetrahedral DNA nanostructure having a 20-mer duplex on each side that can be specifically distributed into...

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Veröffentlicht in:	Biomaterials science 2020-01, Vol.8 (2), p.586-590
Hauptverfasser:	Kim, Kyoung-Ran, Jegal, Hyun, Kim, Junghyun, Ahn, Dae-Ro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol Deoxyribonucleic acid DNA Liver Nucleic acids Self-assembly Tetrahedra
Online-Zugang:	Volltext
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