miR-223-3p promotes cell proliferation and invasion by targeting Arid1a in gastric cancer

miR-223-3p promotes cell proliferation and invasion by targeting Arid1a in gastric cancer

Abstract Accumulating evidence has indicated that microRNAs can regulate downstream signaling pathways and play an important role in various tumors. In this study, we found that miR-223-3p was differentially expressed in 40 paired gastric cancer tissues and adjacent tissues and that miR-223-3p was p...

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Veröffentlicht in:Acta biochimica et biophysica Sinica 2020-02, Vol.52 (2), p.150-159
Hauptverfasser: Zhu, Yiping, Li, Kai, Yan, Liang, He, Yang, Wang, Lu, Sheng, Lili
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container_title Acta biochimica et biophysica Sinica
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creator Zhu, Yiping
Li, Kai
Yan, Liang
He, Yang
Wang, Lu
Sheng, Lili
description Abstract Accumulating evidence has indicated that microRNAs can regulate downstream signaling pathways and play an important role in various tumors. In this study, we found that miR-223-3p was differentially expressed in 40 paired gastric cancer tissues and adjacent tissues and that miR-223-3p was positively correlated with tumor invasion depth and lymph node metastasis. Luciferase reporter assay confirmed that Arid1a was the target gene of miR-223-3p. Functional assays showed that miR-223-3p promoted the proliferation and invasion of gastric cancer cells by regulating the expression of Arid1a. We also confirmed that miR-223-3p regulated the growth of gastric cancer cells in vivo, while an antagomir against miR-223-3p significantly inhibited tumor growth. In conclusion, our results demonstrated that miR-223-3p inhibits gastric cancer cell progression by decreasing the expression of Arid1a. Therefore, miR-223-3p may act as a potential therapeutic target for patients with gastric cancer.
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title miR-223-3p promotes cell proliferation and invasion by targeting Arid1a in gastric cancer
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