Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3K-AKT related signal pathway in SMMC7721 cancer cells

A previously undescribed taraxerene-type triterpenoid possessing a class of rare natural taraxerene triterpenoid possessing skeleton with 14, 28-lactone, two undescribed oleane-type triterpenoids, and twenty-five known triterpenoids were isolated from Liquidambar formosana (Hamamelidaceae). The stru...

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Veröffentlicht in:	Phytochemistry (Oxford) 2020-03, Vol.171, p.112228-112228, Article 112228
Hauptverfasser:	Zhang, Hui-xing, Kang, You, Li, Ning, Wang, Hai-feng, Bao, Yong-rui, Li, Yan-wu, Li, Xue-zheng, Jiang, Zhe, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Cell Proliferation - drug effects Drug Screening Assays, Antitumor Hamamelidaceae Humans Liquidambar - chemistry Liquidambaris fructus Phosphatidylinositol 3-Kinases - metabolism Phytochemicals - chemistry Phytochemicals - isolation & purification Phytochemicals - pharmacology PI3K-AKT pathway Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - isolation & purification Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenoids Tumor Cells, Cultured
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