The interaction of an amorphous metal-organic cage-based solid (aMOC) with miRNA/DNA and its application on a quartz crystal microbalance (QCM) sensor

The interaction of an amorphous metal-organic cage-based solid (aMOC) with miRNA/DNA and its application on a quartz crystal microbalance (QCM) sensor

The interaction between an aMOC and miRNA/DNA is studied and the use of a signal probe DNA (spDNA)@aMOC complex as an effective amplifier in a QCM sensor to detect miRNA is developed. The signal can be significantly enhanced, which leads to improved performance when detecting and distinguishing miRN...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (4), p.591-594
Hauptverfasser: Jin, Xia, Zhang, Yu-Ping, Li, Dian-Mei, Ma, Ding, Zheng, Sheng-Run, Wu, Chu-Hong, Li, Jia-Ying, Zhang, Wei-Guang
Format: Artikel
Sprache:eng
Schlagworte:
Biosensing Techniques
Chemistry
Chemistry, Multidisciplinary
Deoxyribonucleic acid
DNA
DNA - chemistry
Metal-Organic Frameworks - chemistry
Microbalances
MicroRNAs - chemistry
Molecular Structure
Particle Size
Physical Sciences
Porosity
Quartz Crystal Microbalance Techniques
Quartz crystals
Science & Technology
Surface Properties
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Zusammenfassung:The interaction between an aMOC and miRNA/DNA is studied and the use of a signal probe DNA (spDNA)@aMOC complex as an effective amplifier in a QCM sensor to detect miRNA is developed. The signal can be significantly enhanced, which leads to improved performance when detecting and distinguishing miRNAs. The interaction between an aMOC and miRNA/DNA is studied and the use of the aMOC as an effective amplifier in a QCM sensor to detect miRNA is developed for the first time.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc08014g