Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics

To address the global challenge of emerging antimicrobial resistance, the hitherto most successful strategy to new antibiotics has been the optimization of validated natural products; most of these efforts rely on semisynthesis. Herein, we report the semisynthetic modification of amidochelocardin, a...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of medicinal chemistry 2020-02, Vol.188, p.112005-112005, Article 112005
Hauptverfasser:	Grandclaudon, Charlotte, Birudukota, N.V. Suryanarayana, Elgaher, Walid A.M., Jumde, Ravindra P., Yahiaoui, Samir, Arisetti, Nanaji, Hennessen, Fabienne, Hüttel, Stephan, Stadler, Marc, Herrmann, Jennifer, Miethke, Marcus, Hartmann, Rolf W., Müller, Rolf, Hirsch, Anna K.H., Brönstrup, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Chelocardin Gram-negative bacteria Natural product Semisynthesis Tetracycline
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!