Polycyclic aromatic hydrocarbon exposure, miRNA genetic variations, and associated leukocyte mitochondrial DNA copy number: A cross-sectional study in China
Mitochondria DNA was preferentially attacked by the exogenous carcinogens including polycyclic aromatic hydrocarbons (PAHs) relative to nuclear DNA, and nuclear gene variants may account for variability in the mitochondrial DNA copy number (mtDNAcn). However, it remains unclear whether miRNA genetic...
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| Veröffentlicht in: | Chemosphere (Oxford) 2020-05, Vol.246, p.125773-125773, Article 125773 |
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| creator | Duan, Xiaoran Yang, Yongli Zhang, Hui Liu, Bin Wei, Wan Wang, Liuya Sun, Changqing Yao, Wu Cui, Liuxin Zhou, Xiaoshan Wang, Wei |
| description | Mitochondria DNA was preferentially attacked by the exogenous carcinogens including polycyclic aromatic hydrocarbons (PAHs) relative to nuclear DNA, and nuclear gene variants may account for variability in the mitochondrial DNA copy number (mtDNAcn). However, it remains unclear whether miRNA genetic variations are associated with mitochondrial DNA damage in the PAH-exposed workers. Therefore, we measured the leukocyte mtDNAcn, urinary 1-hydroxypyrene (1-OHPYR), environmental PAH exposure, and miRNA genetic polymorphisms among 544 coke oven workers and 238 healthy control participants. We found that the mtDNAcn in the exposure group (0.60 ± 0.29) was significantly lower than that in the control group (1.03 ± 0.31) (t = 18.931, P |
| doi_str_mv | 10.1016/j.chemosphere.2019.125773 |
| format | Article |
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[Display omitted]
•mtDNAcn decreased with environmental PAH exposure.•miR-210 rs11246190 GG was a protective factor of mtDNAcn.•The other 14 polymorphisms in miRNA had null effects on mtDNAcn.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2019.125773</identifier><identifier>PMID: 31911328</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Carcinogens - analysis ; China ; Coke - analysis ; Cross-Sectional Studies ; DNA Copy Number Variations ; DNA Damage ; DNA, Complementary ; DNA, Mitochondrial - genetics ; Environmental Exposure - analysis ; Environmental Exposure - statistics & numerical data ; Environmental Pollutants - analysis ; Environmental Pollutants - toxicity ; Female ; Humans ; Leukocytes - chemistry ; Male ; MicroRNAs - metabolism ; Middle Aged ; miRNA ; Mitochondria - genetics ; Mitochondrial DNA copy number ; Occupational Exposure - analysis ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - analysis ; Polycyclic Aromatic Hydrocarbons - metabolism ; Polycyclic Aromatic Hydrocarbons - toxicity ; rs11246190 ; Young Adult</subject><ispartof>Chemosphere (Oxford), 2020-05, Vol.246, p.125773-125773, Article 125773</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-50a91251fdd96c77cd23fc202ef6130aad9c34da95feda38bca0a956c2c485a23</citedby><cites>FETCH-LOGICAL-c377t-50a91251fdd96c77cd23fc202ef6130aad9c34da95feda38bca0a956c2c485a23</cites><orcidid>0000-0002-5278-5538 ; 0000-0001-8533-7750 ; 0000-0002-0708-8848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0045653519330140$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31911328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, Xiaoran</creatorcontrib><creatorcontrib>Yang, Yongli</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Wei, Wan</creatorcontrib><creatorcontrib>Wang, Liuya</creatorcontrib><creatorcontrib>Sun, Changqing</creatorcontrib><creatorcontrib>Yao, Wu</creatorcontrib><creatorcontrib>Cui, Liuxin</creatorcontrib><creatorcontrib>Zhou, Xiaoshan</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>Polycyclic aromatic hydrocarbon exposure, miRNA genetic variations, and associated leukocyte mitochondrial DNA copy number: A cross-sectional study in China</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>Mitochondria DNA was preferentially attacked by the exogenous carcinogens including polycyclic aromatic hydrocarbons (PAHs) relative to nuclear DNA, and nuclear gene variants may account for variability in the mitochondrial DNA copy number (mtDNAcn). However, it remains unclear whether miRNA genetic variations are associated with mitochondrial DNA damage in the PAH-exposed workers. Therefore, we measured the leukocyte mtDNAcn, urinary 1-hydroxypyrene (1-OHPYR), environmental PAH exposure, and miRNA genetic polymorphisms among 544 coke oven workers and 238 healthy control participants. We found that the mtDNAcn in the exposure group (0.60 ± 0.29) was significantly lower than that in the control group (1.03 ± 0.31) (t = 18.931, P < 0.001). Spearman correlation analysis showed that the peripheral blood leukocyte mtDNAcn had significantly negative correlations with the levels of 1-OHPYR and environmental PAH exposure (P < 0.001). Covariance analysis indicated that miR-210 rs11246190 AA, miR-210 rs7395206 CC, and miR-126 rs2297538 GG probably promoted a decrease in leukocyte mtDNAcn in the exposure or control groups (P < 0.05). In generalized linear model, miR-210 rs11246190 GG was a protective factor of mtDNAcn, and environmental PAH exposure was the risk factor of the mtDNAcn. In conclusion, the decrease of leukocyte mtDNAcn is the result of a combination of environmental and genetic factors.
[Display omitted]
•mtDNAcn decreased with environmental PAH exposure.•miR-210 rs11246190 GG was a protective factor of mtDNAcn.•The other 14 polymorphisms in miRNA had null effects on mtDNAcn.</description><subject>Adult</subject><subject>Carcinogens - analysis</subject><subject>China</subject><subject>Coke - analysis</subject><subject>Cross-Sectional Studies</subject><subject>DNA Copy Number Variations</subject><subject>DNA Damage</subject><subject>DNA, Complementary</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental Pollutants - analysis</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocytes - chemistry</subject><subject>Male</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Mitochondria - genetics</subject><subject>Mitochondrial DNA copy number</subject><subject>Occupational Exposure - analysis</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Polycyclic Aromatic Hydrocarbons - metabolism</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>rs11246190</subject><subject>Young Adult</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0EotPCKyCzY9EMvoyTmF01pYBUAUKwtjzHJ8RDYg92UpF34WHxMAWxZOWLvu8cH_-EPOdszRmvX-7X0OMY86HHhGvBuF5zoZpGPiAr3ja64kK3D8mKsY2qaiXVGTnPec9YkZV-TM4k15xL0a7Iz49xWGCBwQO1KY52Kpt-cSmCTbsYKP44xDwnvKSj__T-in7FgEfmziZf4BjyJbXBUZtzhHKDjg44f4uwTFiUKUIfgyvsQK-LDvGw0DCPO0yvaDmmmHOVEY6VCpKn2S3UB7rtfbBPyKPODhmf3q8X5MvN68_bt9Xthzfvtle3FcimmSrFrC7z8845XUPTgBOyA8EEdjWXzFqnQW6c1apDZ2W7A1sMVYOATauskBfkxanuIcXvM-bJjD4DDoMNGOdshJSbWtdctQXVJ_T3yxN25pD8aNNiODPHcMze_BOOOYZjTuEU99l9m3k3ovtr_kmjANsTgGXYO4_JZPAYAJ1P5YuMi_4_2vwCsZGqgQ</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Duan, Xiaoran</creator><creator>Yang, Yongli</creator><creator>Zhang, Hui</creator><creator>Liu, Bin</creator><creator>Wei, Wan</creator><creator>Wang, Liuya</creator><creator>Sun, Changqing</creator><creator>Yao, Wu</creator><creator>Cui, Liuxin</creator><creator>Zhou, Xiaoshan</creator><creator>Wang, Wei</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5278-5538</orcidid><orcidid>https://orcid.org/0000-0001-8533-7750</orcidid><orcidid>https://orcid.org/0000-0002-0708-8848</orcidid></search><sort><creationdate>202005</creationdate><title>Polycyclic aromatic hydrocarbon exposure, miRNA genetic variations, and associated leukocyte mitochondrial DNA copy number: A cross-sectional study in China</title><author>Duan, Xiaoran ; Yang, Yongli ; Zhang, Hui ; Liu, Bin ; Wei, Wan ; Wang, Liuya ; Sun, Changqing ; Yao, Wu ; Cui, Liuxin ; Zhou, Xiaoshan ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-50a91251fdd96c77cd23fc202ef6130aad9c34da95feda38bca0a956c2c485a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Carcinogens - analysis</topic><topic>China</topic><topic>Coke - analysis</topic><topic>Cross-Sectional Studies</topic><topic>DNA Copy Number Variations</topic><topic>DNA Damage</topic><topic>DNA, Complementary</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Environmental Pollutants - analysis</topic><topic>Environmental Pollutants - toxicity</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocytes - chemistry</topic><topic>Male</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Mitochondria - genetics</topic><topic>Mitochondrial DNA copy number</topic><topic>Occupational Exposure - analysis</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Polycyclic Aromatic Hydrocarbons - metabolism</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>rs11246190</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Xiaoran</creatorcontrib><creatorcontrib>Yang, Yongli</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Wei, Wan</creatorcontrib><creatorcontrib>Wang, Liuya</creatorcontrib><creatorcontrib>Sun, Changqing</creatorcontrib><creatorcontrib>Yao, Wu</creatorcontrib><creatorcontrib>Cui, Liuxin</creatorcontrib><creatorcontrib>Zhou, Xiaoshan</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Xiaoran</au><au>Yang, Yongli</au><au>Zhang, Hui</au><au>Liu, Bin</au><au>Wei, Wan</au><au>Wang, Liuya</au><au>Sun, Changqing</au><au>Yao, Wu</au><au>Cui, Liuxin</au><au>Zhou, Xiaoshan</au><au>Wang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polycyclic aromatic hydrocarbon exposure, miRNA genetic variations, and associated leukocyte mitochondrial DNA copy number: A cross-sectional study in China</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2020-05</date><risdate>2020</risdate><volume>246</volume><spage>125773</spage><epage>125773</epage><pages>125773-125773</pages><artnum>125773</artnum><issn>0045-6535</issn><eissn>1879-1298</eissn><abstract>Mitochondria DNA was preferentially attacked by the exogenous carcinogens including polycyclic aromatic hydrocarbons (PAHs) relative to nuclear DNA, and nuclear gene variants may account for variability in the mitochondrial DNA copy number (mtDNAcn). However, it remains unclear whether miRNA genetic variations are associated with mitochondrial DNA damage in the PAH-exposed workers. Therefore, we measured the leukocyte mtDNAcn, urinary 1-hydroxypyrene (1-OHPYR), environmental PAH exposure, and miRNA genetic polymorphisms among 544 coke oven workers and 238 healthy control participants. We found that the mtDNAcn in the exposure group (0.60 ± 0.29) was significantly lower than that in the control group (1.03 ± 0.31) (t = 18.931, P < 0.001). Spearman correlation analysis showed that the peripheral blood leukocyte mtDNAcn had significantly negative correlations with the levels of 1-OHPYR and environmental PAH exposure (P < 0.001). Covariance analysis indicated that miR-210 rs11246190 AA, miR-210 rs7395206 CC, and miR-126 rs2297538 GG probably promoted a decrease in leukocyte mtDNAcn in the exposure or control groups (P < 0.05). In generalized linear model, miR-210 rs11246190 GG was a protective factor of mtDNAcn, and environmental PAH exposure was the risk factor of the mtDNAcn. In conclusion, the decrease of leukocyte mtDNAcn is the result of a combination of environmental and genetic factors.
[Display omitted]
•mtDNAcn decreased with environmental PAH exposure.•miR-210 rs11246190 GG was a protective factor of mtDNAcn.•The other 14 polymorphisms in miRNA had null effects on mtDNAcn.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31911328</pmid><doi>10.1016/j.chemosphere.2019.125773</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5278-5538</orcidid><orcidid>https://orcid.org/0000-0001-8533-7750</orcidid><orcidid>https://orcid.org/0000-0002-0708-8848</orcidid></addata></record> |
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| subjects | Adult Carcinogens - analysis China Coke - analysis Cross-Sectional Studies DNA Copy Number Variations DNA Damage DNA, Complementary DNA, Mitochondrial - genetics Environmental Exposure - analysis Environmental Exposure - statistics & numerical data Environmental Pollutants - analysis Environmental Pollutants - toxicity Female Humans Leukocytes - chemistry Male MicroRNAs - metabolism Middle Aged miRNA Mitochondria - genetics Mitochondrial DNA copy number Occupational Exposure - analysis Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - analysis Polycyclic Aromatic Hydrocarbons - metabolism Polycyclic Aromatic Hydrocarbons - toxicity rs11246190 Young Adult |
| title | Polycyclic aromatic hydrocarbon exposure, miRNA genetic variations, and associated leukocyte mitochondrial DNA copy number: A cross-sectional study in China |
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