Catalytic mechanism and evolutionary characteristics of thioredoxin from Halobacterium salinarum NRC‐1

Thioredoxin (TRX) is an important antioxidant against oxidative stress. TRX from the extremely halophilic archaeon Halobacterium salinarum NRC‐1 (HsTRX‐A), which has the highest acidic residue content [(Asp + Glu)/(Arg + Lys + His) = 9.0] among known TRXs, was chosen to elucidate the catalytic mecha...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2020-01, Vol.76 (1), p.73-84
Hauptverfasser:	Arai, Shigeki, Shibazaki, Chie, Shimizu, Rumi, Adachi, Motoyasu, Ishibashi, Matsujiro, Tokunaga, Hiroko, Tokunaga, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Biotechnology Crystallography Dichroism Elongation Enzymatic activity Halobacterium salinarum Halobacterium salinarum NRC‐1 halophile Homology Molecular evolution Mutants Oxidative stress Sodium chloride Structural stability Substrates Thioredoxin
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