Effect of obstructive sleep apnea syndrome on glycolipid metabolism and early atherosclerosis in diabetics
To study the changes in glucose and lipid metabolism indexes and the condition of early atherosclerosis in patients with diabetes with and without obstructive sleep apnea syndrome (OSAS). Patients with type 2 diabetes mellitus (DM) aged 32–50 years who did not have significant complications were inc...
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| Veröffentlicht in: | Diabetes research and clinical practice 2020-01, Vol.159, p.107999-107999, Article 107999 |
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| container_title | Diabetes research and clinical practice |
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| creator | Wang, Jue Hu, Liye Wang, Zhenxian Yang, Shaoling Wu, Shan |
| description | To study the changes in glucose and lipid metabolism indexes and the condition of early atherosclerosis in patients with diabetes with and without obstructive sleep apnea syndrome (OSAS).
Patients with type 2 diabetes mellitus (DM) aged 32–50 years who did not have significant complications were included. A total of 42 patients with DM with OSAS and 46 patients with DM without OSAS were chosen according to their sleep monitoring indexes. Height and weight were measured, and fasting blood glucose, postprandial blood glucose, endothelin (ET), nitric oxide (NO) and lipid profile were tested. Then, all the subjects were subjected to the pulse wave velocity (PWV) test.
The levels of glycated haemoglobin and triglycerides were significantly higher in patients with DM with OSAS than those in patients with DM without OSAS. ET, NO and PWV changed significantly.
Patients with diabetes with OSAS are more likely to have complications related to arteriosclerosis and aggravation of glycolipid metabolism disorder. Early intervention is recommended. |
| doi_str_mv | 10.1016/j.diabres.2020.107999 |
| format | Article |
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Patients with type 2 diabetes mellitus (DM) aged 32–50 years who did not have significant complications were included. A total of 42 patients with DM with OSAS and 46 patients with DM without OSAS were chosen according to their sleep monitoring indexes. Height and weight were measured, and fasting blood glucose, postprandial blood glucose, endothelin (ET), nitric oxide (NO) and lipid profile were tested. Then, all the subjects were subjected to the pulse wave velocity (PWV) test.
The levels of glycated haemoglobin and triglycerides were significantly higher in patients with DM with OSAS than those in patients with DM without OSAS. ET, NO and PWV changed significantly.
Patients with diabetes with OSAS are more likely to have complications related to arteriosclerosis and aggravation of glycolipid metabolism disorder. Early intervention is recommended.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2020.107999</identifier><identifier>PMID: 31904443</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Atherosclerosis - etiology ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Atherosclerosis - physiopathology ; Blood Glucose - metabolism ; Case-Control Studies ; Diabetes mellitus, type 2 ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Angiopathies - metabolism ; Diabetic Angiopathies - physiopathology ; Disease Progression ; Female ; Glycated haemoglobin ; Glycated Hemoglobin A - metabolism ; Glycolipids - metabolism ; Humans ; Lipid Metabolism ; Male ; Middle Aged ; Polysomnography ; Pulse Wave Analysis ; Pulse wave velocity ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - metabolism ; Sleep Apnea, Obstructive - physiopathology</subject><ispartof>Diabetes research and clinical practice, 2020-01, Vol.159, p.107999-107999, Article 107999</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-764fce3127aa68ca9b6822643a3991b3f0f96adb16e0e5d3d43263382547944f3</citedby><cites>FETCH-LOGICAL-c365t-764fce3127aa68ca9b6822643a3991b3f0f96adb16e0e5d3d43263382547944f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2020.107999$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31904443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Hu, Liye</creatorcontrib><creatorcontrib>Wang, Zhenxian</creatorcontrib><creatorcontrib>Yang, Shaoling</creatorcontrib><creatorcontrib>Wu, Shan</creatorcontrib><title>Effect of obstructive sleep apnea syndrome on glycolipid metabolism and early atherosclerosis in diabetics</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>To study the changes in glucose and lipid metabolism indexes and the condition of early atherosclerosis in patients with diabetes with and without obstructive sleep apnea syndrome (OSAS).
Patients with type 2 diabetes mellitus (DM) aged 32–50 years who did not have significant complications were included. A total of 42 patients with DM with OSAS and 46 patients with DM without OSAS were chosen according to their sleep monitoring indexes. Height and weight were measured, and fasting blood glucose, postprandial blood glucose, endothelin (ET), nitric oxide (NO) and lipid profile were tested. Then, all the subjects were subjected to the pulse wave velocity (PWV) test.
The levels of glycated haemoglobin and triglycerides were significantly higher in patients with DM with OSAS than those in patients with DM without OSAS. ET, NO and PWV changed significantly.
Patients with diabetes with OSAS are more likely to have complications related to arteriosclerosis and aggravation of glycolipid metabolism disorder. Early intervention is recommended.</description><subject>Adult</subject><subject>Atherosclerosis - etiology</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - physiopathology</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes mellitus, type 2</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Angiopathies - metabolism</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Glycated haemoglobin</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Glycolipids - metabolism</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polysomnography</subject><subject>Pulse Wave Analysis</subject><subject>Pulse wave velocity</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - metabolism</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu3CAQQFGVqtmk_YRWHHPZLTAYm1MVRWkTKVIv7RlhGFpWtnHBG2n_vri7zTUXZjR6w8w8Qj5ytuOMq8_7nY-2z1h2gom11mqt35AN71qx7YRoL8imct2__JJclbJnjCmQzTtyCVwzKSVsyP4-BHQLTYGmviz54Jb4jLQMiDO184SWluPkcxqRpon-Go4uDXGOno642L7mZaR28hRtHo7ULr8xp-KG9Y2Fxomua-ISXXlP3gY7FPxwjtfk59f7H3cP26fv3x7vbp-2DlSzbFslg0PgorVWdc7qXtUTlAQLWvMeAgtaWd9zhQwbD16CUACdaGSrpQxwTW5O_845_TlgWcwYi8NhsBOmQzECADSIRoiKNifU1XVLxmDmHEebj4Yzs2o2e3PWbFbN5qS59n06jzj0I_qXrv9eK_DlBGA99DliNsVFnBz6mKtu41N8ZcRfOdSR8g</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Wang, Jue</creator><creator>Hu, Liye</creator><creator>Wang, Zhenxian</creator><creator>Yang, Shaoling</creator><creator>Wu, Shan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>Effect of obstructive sleep apnea syndrome on glycolipid metabolism and early atherosclerosis in diabetics</title><author>Wang, Jue ; Hu, Liye ; Wang, Zhenxian ; Yang, Shaoling ; Wu, Shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-764fce3127aa68ca9b6822643a3991b3f0f96adb16e0e5d3d43263382547944f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Atherosclerosis - etiology</topic><topic>Atherosclerosis - metabolism</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - physiopathology</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes mellitus, type 2</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Angiopathies - metabolism</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Glycated haemoglobin</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Glycolipids - metabolism</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polysomnography</topic><topic>Pulse Wave Analysis</topic><topic>Pulse wave velocity</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - metabolism</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Hu, Liye</creatorcontrib><creatorcontrib>Wang, Zhenxian</creatorcontrib><creatorcontrib>Yang, Shaoling</creatorcontrib><creatorcontrib>Wu, Shan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jue</au><au>Hu, Liye</au><au>Wang, Zhenxian</au><au>Yang, Shaoling</au><au>Wu, Shan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of obstructive sleep apnea syndrome on glycolipid metabolism and early atherosclerosis in diabetics</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2020-01</date><risdate>2020</risdate><volume>159</volume><spage>107999</spage><epage>107999</epage><pages>107999-107999</pages><artnum>107999</artnum><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>To study the changes in glucose and lipid metabolism indexes and the condition of early atherosclerosis in patients with diabetes with and without obstructive sleep apnea syndrome (OSAS).
Patients with type 2 diabetes mellitus (DM) aged 32–50 years who did not have significant complications were included. A total of 42 patients with DM with OSAS and 46 patients with DM without OSAS were chosen according to their sleep monitoring indexes. Height and weight were measured, and fasting blood glucose, postprandial blood glucose, endothelin (ET), nitric oxide (NO) and lipid profile were tested. Then, all the subjects were subjected to the pulse wave velocity (PWV) test.
The levels of glycated haemoglobin and triglycerides were significantly higher in patients with DM with OSAS than those in patients with DM without OSAS. ET, NO and PWV changed significantly.
Patients with diabetes with OSAS are more likely to have complications related to arteriosclerosis and aggravation of glycolipid metabolism disorder. Early intervention is recommended.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31904443</pmid><doi>10.1016/j.diabres.2020.107999</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - physiopathology Blood Glucose - metabolism Case-Control Studies Diabetes mellitus, type 2 Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - metabolism Diabetic Angiopathies - physiopathology Disease Progression Female Glycated haemoglobin Glycated Hemoglobin A - metabolism Glycolipids - metabolism Humans Lipid Metabolism Male Middle Aged Polysomnography Pulse Wave Analysis Pulse wave velocity Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - metabolism Sleep Apnea, Obstructive - physiopathology |
| title | Effect of obstructive sleep apnea syndrome on glycolipid metabolism and early atherosclerosis in diabetics |
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