Treatment of erosive pustular dermatosis: a systematic review of the literature

Importance Erosive pustular dermatosis (EPD) is a rare chronic inflammatory condition of the scalp and legs that is often difficult to manage. Currently, there are no treatment guidelines. Objective To systematically assess the existing literature on various treatment modalities and their efficacies...

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Veröffentlicht in:International journal of dermatology 2020-07, Vol.59 (7), p.770-786
Hauptverfasser: Lee, Katrina H., Carley, Sama K., Kraus, Christina N., Mesinkovska, Natasha A.
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container_end_page 786
container_issue 7
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container_title International journal of dermatology
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creator Lee, Katrina H.
Carley, Sama K.
Kraus, Christina N.
Mesinkovska, Natasha A.
description Importance Erosive pustular dermatosis (EPD) is a rare chronic inflammatory condition of the scalp and legs that is often difficult to manage. Currently, there are no treatment guidelines. Objective To systematically assess the existing literature on various treatment modalities and their efficacies when used in the management of EPD. Evidence review We searched PubMed, Cochrane Libraries, Scopus, and clicnialtrial.gov databases for articles in the English language with no limited time frame. Emphasis was placed on articles that reported on treatment for EPD. Findings Of the 168 articles identified by the literature search, 92 met eligibility criteria and were included for qualitative analysis. Efficacious topical treatments included clobetasol, betamethasone, and tacrolimus. Ninety‐three and 88% of cases utilizing clobetasol and betamethasone respectively demonstrated improvement or resolution. All 32 cases utilizing tacrolimus reported improvement. Efficacious systemic treatments included oral steroids such as prednisone, methylprednisolone, and dexamethasone. Topical dapsone, photodynamic therapy, systemic steroids, cyclosporine, and oral zinc derivatives were also described with some success. Conclusions and relevance According to available data, limited solely to case reports and case series, potent topical steroids are an effective treatment option for EPD. Topical tacrolimus may also be considered in cases that require long‐term use or maintenance. Other treatment modalities shown to be successful based on high reported efficacy and low rates of recurrence after treatment include topical dapsone, systemic steroids, zinc derivatives, and cyclosporine. Further studies are needed to compare treatment modalities and to establish treatment protocols.
doi_str_mv 10.1111/ijd.14744
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Currently, there are no treatment guidelines. Objective To systematically assess the existing literature on various treatment modalities and their efficacies when used in the management of EPD. Evidence review We searched PubMed, Cochrane Libraries, Scopus, and clicnialtrial.gov databases for articles in the English language with no limited time frame. Emphasis was placed on articles that reported on treatment for EPD. Findings Of the 168 articles identified by the literature search, 92 met eligibility criteria and were included for qualitative analysis. Efficacious topical treatments included clobetasol, betamethasone, and tacrolimus. Ninety‐three and 88% of cases utilizing clobetasol and betamethasone respectively demonstrated improvement or resolution. All 32 cases utilizing tacrolimus reported improvement. Efficacious systemic treatments included oral steroids such as prednisone, methylprednisolone, and dexamethasone. Topical dapsone, photodynamic therapy, systemic steroids, cyclosporine, and oral zinc derivatives were also described with some success. Conclusions and relevance According to available data, limited solely to case reports and case series, potent topical steroids are an effective treatment option for EPD. Topical tacrolimus may also be considered in cases that require long‐term use or maintenance. Other treatment modalities shown to be successful based on high reported efficacy and low rates of recurrence after treatment include topical dapsone, systemic steroids, zinc derivatives, and cyclosporine. 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Topical dapsone, photodynamic therapy, systemic steroids, cyclosporine, and oral zinc derivatives were also described with some success. Conclusions and relevance According to available data, limited solely to case reports and case series, potent topical steroids are an effective treatment option for EPD. Topical tacrolimus may also be considered in cases that require long‐term use or maintenance. Other treatment modalities shown to be successful based on high reported efficacy and low rates of recurrence after treatment include topical dapsone, systemic steroids, zinc derivatives, and cyclosporine. 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dosage</topic><topic>Tacrolimus - therapeutic use</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Katrina H.</creatorcontrib><creatorcontrib>Carley, Sama K.</creatorcontrib><creatorcontrib>Kraus, Christina N.</creatorcontrib><creatorcontrib>Mesinkovska, Natasha A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Katrina H.</au><au>Carley, Sama K.</au><au>Kraus, Christina N.</au><au>Mesinkovska, Natasha A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of erosive pustular dermatosis: a systematic review of the literature</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2020-07</date><risdate>2020</risdate><volume>59</volume><issue>7</issue><spage>770</spage><epage>786</epage><pages>770-786</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Importance Erosive pustular dermatosis (EPD) is a rare chronic inflammatory condition of the scalp and legs that is often difficult to manage. 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subjects Administration, Cutaneous
Administration, Oral
Anti-Infective Agents - therapeutic use
Betamethasone - therapeutic use
Calcineurin Inhibitors - administration & dosage
Calcineurin Inhibitors - therapeutic use
Case reports
Clobetasol - therapeutic use
Cyclosporins
Dapsone
Dapsone - therapeutic use
Derivatives
Dexamethasone
Dexamethasone - therapeutic use
Diaminodiphenylsulfone
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Inflammation
Leg Dermatoses - drug therapy
Literature reviews
Methylprednisolone
Methylprednisolone - therapeutic use
Photochemotherapy
Photodynamic therapy
Prednisone
Qualitative analysis
Scalp
Scalp Dermatoses - drug therapy
Skin diseases
Steroid hormones
Steroids
Tacrolimus
Tacrolimus - administration & dosage
Tacrolimus - therapeutic use
Zinc
title Treatment of erosive pustular dermatosis: a systematic review of the literature
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