Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis
Rheumatoid arthritis is diagnosed based on the 2010 Rheumatoid Arthritis Classification Criteria whereby rheumatoid factor and anti-citrullinated protein antibody are the serological markers included in these criteria. Anti-RA33 antibody has the potential to provide additional diagnostic value in rh...
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| Veröffentlicht in: | Malaysian journal of pathology 2019-12, Vol.41 (3), p.259-265 |
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| container_title | Malaysian journal of pathology |
| container_volume | 41 |
| creator | Syed Mohamed Suhail, S M Nur Atiqah, I Nur Salimi Zakirah, Z A Lailatul Syazwani, Z Batis, W W Md Monoto, E M Abdul Wahab, A Mohd Shahrir, M S |
| description | Rheumatoid arthritis is diagnosed based on the 2010 Rheumatoid Arthritis Classification Criteria whereby rheumatoid factor and anti-citrullinated protein antibody are the serological markers included in these criteria. Anti-RA33 antibody has the potential to provide additional diagnostic value in rheumatoid arthritis. The aim of this study is to determine the diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis.
Thirtyfour patients with rheumatoid arthritis and 34 non-rheumatoid arthritis individuals were included in this cross-sectional study. Anti-RA33 antibody and rheumatoid factor were performed on all samples.
The sensitivity, specificity, positive and negative predictive value for anti-RA33 antibody and rheumatoid factor were 41.1%, 97.1%, 93.3%, 62.3% and 64.7%, 79.4%, 75.9%, 69.2% respectively. The overall sensitivity and specificity if either anti-RA33 antibody or rheumatoid factor are positive were 79.4% and 76.47% respectively.
Anti-RA33 antibody showed good specificity and positive predictive value and could be considered as a potential serological marker for rheumatoid arthritis diagnosis. |
| format | Article |
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Thirtyfour patients with rheumatoid arthritis and 34 non-rheumatoid arthritis individuals were included in this cross-sectional study. Anti-RA33 antibody and rheumatoid factor were performed on all samples.
The sensitivity, specificity, positive and negative predictive value for anti-RA33 antibody and rheumatoid factor were 41.1%, 97.1%, 93.3%, 62.3% and 64.7%, 79.4%, 75.9%, 69.2% respectively. The overall sensitivity and specificity if either anti-RA33 antibody or rheumatoid factor are positive were 79.4% and 76.47% respectively.
Anti-RA33 antibody showed good specificity and positive predictive value and could be considered as a potential serological marker for rheumatoid arthritis diagnosis.</description><identifier>ISSN: 0126-8635</identifier><identifier>PMID: 31901910</identifier><language>eng</language><publisher>Malaysia: College of Pathologists, Academy of Medicine of Malaysia</publisher><subject>Classification ; Health risk assessment ; Hospitals ; Laboratories ; Patients ; Population ; Proteins ; Rheumatoid arthritis ; Studies</subject><ispartof>Malaysian journal of pathology, 2019-12, Vol.41 (3), p.259-265</ispartof><rights>Copyright College of Pathologists, Academy of Medicine of Malaysia Dec 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31901910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Syed Mohamed Suhail, S M</creatorcontrib><creatorcontrib>Nur Atiqah, I</creatorcontrib><creatorcontrib>Nur Salimi Zakirah, Z A</creatorcontrib><creatorcontrib>Lailatul Syazwani, Z</creatorcontrib><creatorcontrib>Batis, W W</creatorcontrib><creatorcontrib>Md Monoto, E M</creatorcontrib><creatorcontrib>Abdul Wahab, A</creatorcontrib><creatorcontrib>Mohd Shahrir, M S</creatorcontrib><title>Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis</title><title>Malaysian journal of pathology</title><addtitle>Malays J Pathol</addtitle><description>Rheumatoid arthritis is diagnosed based on the 2010 Rheumatoid Arthritis Classification Criteria whereby rheumatoid factor and anti-citrullinated protein antibody are the serological markers included in these criteria. Anti-RA33 antibody has the potential to provide additional diagnostic value in rheumatoid arthritis. The aim of this study is to determine the diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis.
Thirtyfour patients with rheumatoid arthritis and 34 non-rheumatoid arthritis individuals were included in this cross-sectional study. Anti-RA33 antibody and rheumatoid factor were performed on all samples.
The sensitivity, specificity, positive and negative predictive value for anti-RA33 antibody and rheumatoid factor were 41.1%, 97.1%, 93.3%, 62.3% and 64.7%, 79.4%, 75.9%, 69.2% respectively. The overall sensitivity and specificity if either anti-RA33 antibody or rheumatoid factor are positive were 79.4% and 76.47% respectively.
Anti-RA33 antibody showed good specificity and positive predictive value and could be considered as a potential serological marker for rheumatoid arthritis diagnosis.</description><subject>Classification</subject><subject>Health risk assessment</subject><subject>Hospitals</subject><subject>Laboratories</subject><subject>Patients</subject><subject>Population</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Studies</subject><issn>0126-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0DtPwzAQB3APIFoKXwFZYmGJ5Ef8GqvylCohIRhR5Dh265LEwXYGvj0WlIXpbvjd6f53ApYIE15JTtkCnKd0QIjXSskzsKBYIawwWoL3W693Y0jZGzjZ6EIc9GgsDA7qMfvqZU3pT9eG7gvqBDVMNoY-7LzRPRx0_LARljEY93YedA6-gzrmffTZpwtw6nSf7OWxrsDb_d3r5rHaPj88bdbbaiJU5QozIZwRjtSOCcR0K6XiRhiGMBei5iWHtqxtFa2dYcxgTGopbctR1ymJEF2Bm9-9Uwyfs025GXwytu_1aMOcGkIpVURJIQu9_kcPYY5jua4oRjBDsugVuDqquR1s10zRl6hfzd_j6DfqVGdl</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Syed Mohamed Suhail, S M</creator><creator>Nur Atiqah, I</creator><creator>Nur Salimi Zakirah, Z A</creator><creator>Lailatul Syazwani, Z</creator><creator>Batis, W W</creator><creator>Md Monoto, E M</creator><creator>Abdul Wahab, A</creator><creator>Mohd Shahrir, M S</creator><general>College of Pathologists, Academy of Medicine of Malaysia</general><scope>NPM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis</title><author>Syed Mohamed Suhail, S M ; Nur Atiqah, I ; Nur Salimi Zakirah, Z A ; Lailatul Syazwani, Z ; Batis, W W ; Md Monoto, E M ; Abdul Wahab, A ; Mohd Shahrir, M S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-1577fc7f24f5705ab8896c7c50167746012ae5bb934fc55c112488eb60dd98003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Classification</topic><topic>Health risk assessment</topic><topic>Hospitals</topic><topic>Laboratories</topic><topic>Patients</topic><topic>Population</topic><topic>Proteins</topic><topic>Rheumatoid arthritis</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Syed Mohamed Suhail, S M</creatorcontrib><creatorcontrib>Nur Atiqah, I</creatorcontrib><creatorcontrib>Nur Salimi Zakirah, Z A</creatorcontrib><creatorcontrib>Lailatul Syazwani, Z</creatorcontrib><creatorcontrib>Batis, W W</creatorcontrib><creatorcontrib>Md Monoto, E M</creatorcontrib><creatorcontrib>Abdul Wahab, A</creatorcontrib><creatorcontrib>Mohd Shahrir, M S</creatorcontrib><collection>PubMed</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Malaysian journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Syed Mohamed Suhail, S M</au><au>Nur Atiqah, I</au><au>Nur Salimi Zakirah, Z A</au><au>Lailatul Syazwani, Z</au><au>Batis, W W</au><au>Md Monoto, E M</au><au>Abdul Wahab, A</au><au>Mohd Shahrir, M S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis</atitle><jtitle>Malaysian journal of pathology</jtitle><addtitle>Malays J Pathol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>41</volume><issue>3</issue><spage>259</spage><epage>265</epage><pages>259-265</pages><issn>0126-8635</issn><abstract>Rheumatoid arthritis is diagnosed based on the 2010 Rheumatoid Arthritis Classification Criteria whereby rheumatoid factor and anti-citrullinated protein antibody are the serological markers included in these criteria. Anti-RA33 antibody has the potential to provide additional diagnostic value in rheumatoid arthritis. The aim of this study is to determine the diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis.
Thirtyfour patients with rheumatoid arthritis and 34 non-rheumatoid arthritis individuals were included in this cross-sectional study. Anti-RA33 antibody and rheumatoid factor were performed on all samples.
The sensitivity, specificity, positive and negative predictive value for anti-RA33 antibody and rheumatoid factor were 41.1%, 97.1%, 93.3%, 62.3% and 64.7%, 79.4%, 75.9%, 69.2% respectively. The overall sensitivity and specificity if either anti-RA33 antibody or rheumatoid factor are positive were 79.4% and 76.47% respectively.
Anti-RA33 antibody showed good specificity and positive predictive value and could be considered as a potential serological marker for rheumatoid arthritis diagnosis.</abstract><cop>Malaysia</cop><pub>College of Pathologists, Academy of Medicine of Malaysia</pub><pmid>31901910</pmid><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0126-8635 |
| ispartof | Malaysian journal of pathology, 2019-12, Vol.41 (3), p.259-265 |
| issn | 0126-8635 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Classification Health risk assessment Hospitals Laboratories Patients Population Proteins Rheumatoid arthritis Studies |
| title | Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis |
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