Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice

γ-Aminobutyric acid (GABA) uptake transporters are membrane transport proteins that are involved in the pathophysiology of a number of neurological disorders. Some types of chronic pain appear to result from the dysfunction of the GABAergic system. The deficiency of mouse GAT1 transporter (mGAT1) ab...

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Veröffentlicht in:European journal of medicinal chemistry 2020-02, Vol.188, p.111920-111920, Article 111920
Hauptverfasser: Zaręba, Paula, Gryzło, Beata, Malawska, Katarzyna, Sałat, Kinga, Höfner, Georg C., Nowaczyk, Alicja, Fijałkowski, Łukasz, Rapacz, Anna, Podkowa, Adrian, Furgała, Anna, Żmudzki, Paweł, Wanner, Klaus T., Malawska, Barbara, Kulig, Katarzyna
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Sprache:eng
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