Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates

Since the first report in 2003, bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been increasing, without effective clinical strategies. Osteoporosis is common in elderly women, and bisphosphonates (BPs) are typical and widely used anti-osteoporotic or anti-bone-resorptive drugs. BRONJ is...

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Veröffentlicht in:	YAKUGAKU ZASSHI 2020/01/01, Vol.140(1), pp.63-79
Hauptverfasser:	Endo, Yasuo, Funayama, Hiromi, Yamaguchi, Kouji, Monma, Yuko, Yu, Zhiqian, Deng, Xue, Oizumi, Takefumi, Shikama, Yosuke, Tanaka, Yukinori, Okada, Satoshi, Kim, Siyoung, Kiyama, Tomomi, Bando, Kanan, Shima, Kazuhiro, Suzuki, Hikari, Takahashi, Tetsu
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals bisphosphonate Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control Bone Density Conservation Agents - adverse effects Bone Density Conservation Agents - metabolism Bone Density Conservation Agents - therapeutic use Clinical Trials as Topic clodronate Clodronic Acid - chemistry Clodronic Acid - metabolism Clodronic Acid - pharmacology Clodronic Acid - therapeutic use Diphosphonates - adverse effects Diphosphonates - chemistry Diphosphonates - metabolism Diphosphonates - therapeutic use etidronate Etidronic Acid - chemistry Etidronic Acid - metabolism Etidronic Acid - pharmacology Etidronic Acid - therapeutic use Humans Inflammation Jaw - metabolism Mice necrosis Nitrogen Phosphate Transport Proteins - antagonists & inhibitors phosphate transporter Rats
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