Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety as potential antitumor inhibitor

[Display omitted] A series of pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety were designed, synthesized and evaluated for the anti-proliferative on three cancer cell lines (A549, HepG2 and MCF-7) in vitro. Most of the compounds showed moderate to high potency. Some excellent compou...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-01, Vol.30 (2), p.126848-126848, Article 126848
Hauptverfasser:	Liu, Huimin, Duan, Yongli, Xiong, Hehua, Zhang, Jianqing, Huang, Shunmin, Chen, Ting, Zheng, Pengwu, Tang, Qidong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Oxoquinoline 4-Quinolones - chemical synthesis 4-Quinolones - chemistry Anti-proliferative activity Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use c-Met Humans Molecular Structure Pyridines - chemical synthesis Pyridines - chemistry Pyrrolo[2,3-b]pyridine derivatives Structure-Activity Relationship Synthesis
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