Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults
Abstract Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that cl...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-12, Vol.75 (12), p.2239-2248 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Lammers, Florian Zacharias, Norman Borchers, Friedrich Mörgeli, Rudolf Spies, Claudia Doris Winterer, Georg |
| description | Abstract
Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, that is, (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state functional magnetic resonance imaging, motor-cognitive testing, and assessment of Fried’s modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N = 60) showed higher connectivity in the SMA network compared to frail (N = 13) and prefrail (N = 70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the older adults . The SMA may serve as a potential treatment target in frailty. |
| doi_str_mv | 10.1093/gerona/glz297 |
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Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, that is, (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state functional magnetic resonance imaging, motor-cognitive testing, and assessment of Fried’s modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N = 60) showed higher connectivity in the SMA network compared to frail (N = 13) and prefrail (N = 70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the older adults . The SMA may serve as a potential treatment target in frailty.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glz297</identifier><identifier>PMID: 31900470</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Body weight loss ; Coexistence ; Cognition ; Cognitive ability ; Female ; Frail Elderly ; Frailty ; Frailty - classification ; Functional magnetic resonance imaging ; Geriatric Assessment - methods ; Geriatrics ; Gerontology ; Humans ; Magnetic Resonance Imaging ; Male ; Motor ability ; Motor Cortex - diagnostic imaging ; Motor Cortex - pathology ; Motor task performance ; Neural networks ; Neuroimaging ; Neuropsychological Tests ; Older people ; Patients ; Prospective Studies ; Substantia alba ; Surgery</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2020-12, Vol.75 (12), p.2239-2248</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Dec 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-986f2bcaf37e65f4b1fbe97ee2e793a10c94ae0e9eddbf59be280efd5f967f123</citedby><cites>FETCH-LOGICAL-c382t-986f2bcaf37e65f4b1fbe97ee2e793a10c94ae0e9eddbf59be280efd5f967f123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27913,27914,33763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31900470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Le Couteur, David</contributor><creatorcontrib>Lammers, Florian</creatorcontrib><creatorcontrib>Zacharias, Norman</creatorcontrib><creatorcontrib>Borchers, Friedrich</creatorcontrib><creatorcontrib>Mörgeli, Rudolf</creatorcontrib><creatorcontrib>Spies, Claudia Doris</creatorcontrib><creatorcontrib>Winterer, Georg</creatorcontrib><title>Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, that is, (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state functional magnetic resonance imaging, motor-cognitive testing, and assessment of Fried’s modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N = 60) showed higher connectivity in the SMA network compared to frail (N = 13) and prefrail (N = 70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the older adults . The SMA may serve as a potential treatment target in frailty.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body weight loss</subject><subject>Coexistence</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Female</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Frailty - classification</subject><subject>Functional magnetic resonance imaging</subject><subject>Geriatric Assessment - methods</subject><subject>Geriatrics</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Motor ability</subject><subject>Motor Cortex - diagnostic imaging</subject><subject>Motor Cortex - pathology</subject><subject>Motor task performance</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Substantia alba</subject><subject>Surgery</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BHHNA</sourceid><recordid>eNqFkctO3TAQhq2qqFzaZbeVpW66CfiSxPHy6IhTkKAsaKXuIiceg6lPnNoOR7BAvAavx5NgerhIXbTejGf06ZNmfoQ-UrJLieR7ZxD8oPbO3DWT4g3aoqJqiopXP9_mPxGyqAipN9F2jBfk8VXsHdrkVBJSCrKFbhbT0CebFQ7P_TBAbi5tusLe4HQO-HQaRwdLGJIKV_jYJx_wN0grH37hw4hnMfreqgQar2w6x4tgQd_f3sWMamtyk0fKuiw87X0AbAd84jQEPNOTS_E92jDKRfjwVHfQj8X-9_lBcXTy9XA-Oyp63rBUyKY2rOuV4QLqypQdNR1IAcBASK4o6WWpgIAErTtTyQ5YQ8DoyshaGMr4Dvqy9o7B_54gpnZpYw_OqQH8FFvGOa9JU5cko5__Qi_8FPJ9MlU2vC4ZZc2_KUEJZ_SPq1hTffAxBjDtGOwyX7KlpH2Mr13H167jy_ynJ-vULUG_0M95ve7hp_E_rgc_GKgx</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Lammers, Florian</creator><creator>Zacharias, Norman</creator><creator>Borchers, Friedrich</creator><creator>Mörgeli, Rudolf</creator><creator>Spies, Claudia Doris</creator><creator>Winterer, Georg</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20201201</creationdate><title>Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults</title><author>Lammers, Florian ; Zacharias, Norman ; Borchers, Friedrich ; Mörgeli, Rudolf ; Spies, Claudia Doris ; Winterer, Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-986f2bcaf37e65f4b1fbe97ee2e793a10c94ae0e9eddbf59be280efd5f967f123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body weight loss</topic><topic>Coexistence</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Female</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Frailty - classification</topic><topic>Functional magnetic resonance imaging</topic><topic>Geriatric Assessment - methods</topic><topic>Geriatrics</topic><topic>Gerontology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Motor ability</topic><topic>Motor Cortex - diagnostic imaging</topic><topic>Motor Cortex - pathology</topic><topic>Motor task performance</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Substantia alba</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lammers, Florian</creatorcontrib><creatorcontrib>Zacharias, Norman</creatorcontrib><creatorcontrib>Borchers, Friedrich</creatorcontrib><creatorcontrib>Mörgeli, Rudolf</creatorcontrib><creatorcontrib>Spies, Claudia Doris</creatorcontrib><creatorcontrib>Winterer, Georg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lammers, Florian</au><au>Zacharias, Norman</au><au>Borchers, Friedrich</au><au>Mörgeli, Rudolf</au><au>Spies, Claudia Doris</au><au>Winterer, Georg</au><au>Le Couteur, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>75</volume><issue>12</issue><spage>2239</spage><epage>2248</epage><pages>2239-2248</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Abstract
Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, that is, (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state functional magnetic resonance imaging, motor-cognitive testing, and assessment of Fried’s modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N = 60) showed higher connectivity in the SMA network compared to frail (N = 13) and prefrail (N = 70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the older adults . The SMA may serve as a potential treatment target in frailty.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31900470</pmid><doi>10.1093/gerona/glz297</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Sociological Abstracts; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Body weight loss Coexistence Cognition Cognitive ability Female Frail Elderly Frailty Frailty - classification Functional magnetic resonance imaging Geriatric Assessment - methods Geriatrics Gerontology Humans Magnetic Resonance Imaging Male Motor ability Motor Cortex - diagnostic imaging Motor Cortex - pathology Motor task performance Neural networks Neuroimaging Neuropsychological Tests Older people Patients Prospective Studies Substantia alba Surgery |
| title | Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults |
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