Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial
Objectives In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT). Methods The study included 25 systemically healthy...
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creator | Küçük, Diğdem Savran, Levent Ercan, Utku Kürşat Yarali, Ziyşan Buse Karaman, Ozan Kantarci, Alpdoğan Sağlam, Mehmet Köseoğlu, Serhat |
description | Objectives
In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT).
Methods
The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method.
Results
There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) (
p
|
doi_str_mv | 10.1007/s00784-019-03187-2 |
format | Article |
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In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT).
Methods
The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method.
Results
There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) (
p
< 0.05), but no significant difference between groups in CAL. Clinical periodontal parameters improved in both study groups (
p
< 0.05). However, the gingival index (GI) and the bleeding on probing (BOP) rate decreased more in the test group (GI: 0.55, BOP: 9.48%, and GI: 0.38, BOP: 8.46% in the 1st and 3rd months, respectively) compared to the control group (GI: 0.68, BOP: 13.43%, and GI: 0.52, BOP: 14.58%) (
p
< 0.05). In addition, there was no significant difference in probing depth and biochemical markers between groups (
p
> 0.05). It was observed that NAPP reduced the number of bacteria more than the control group in the 1st and 3rd months.
Conclusions
It was seen that the single-time NAPP application concurrent with NSPT provided additional CAL gain, elimination of putative periodontopathogens and reduced their recolonization. Longitudinal studies with larger population and longer time are required.
Clinical relevance
NSPT is an effective method for the treatment of periodontitis but bacteria recolonization that causes recurrence of the periodontal disease occurs within a short period. NAPP can reduce the recurrence of periodontal disease by providing better bacterial elimination and should, therefore, be used in maintenance of periodontitis.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-019-03187-2</identifier><identifier>PMID: 31897708</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atmospheric pressure ; Bacteria ; Biochemical markers ; Chronic Periodontitis - therapy ; Clinical trials ; Decontamination ; Dental Plaque Index ; Dental Scaling ; Dentistry ; Enzyme-linked immunosorbent assay ; Follow-Up Studies ; Gingiva ; Gingival index ; Gum disease ; Humans ; Medicine ; Original Article ; Patients ; Periodontal Attachment Loss ; Periodontal diseases ; Periodontitis ; Periodontitis - therapy ; Plasma Gases - therapeutic use ; Polymerase chain reaction ; Population studies ; Recolonization ; Root Planing</subject><ispartof>Clinical oral investigations, 2020-09, Vol.24 (9), p.3133-3145</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-659b14ff7cb661bb91473a2e32913f26f38b1c4a661a57d217ab5d10c3e49d83</citedby><cites>FETCH-LOGICAL-c375t-659b14ff7cb661bb91473a2e32913f26f38b1c4a661a57d217ab5d10c3e49d83</cites><orcidid>0000-0002-4121-2494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-019-03187-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-019-03187-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Küçük, Diğdem</creatorcontrib><creatorcontrib>Savran, Levent</creatorcontrib><creatorcontrib>Ercan, Utku Kürşat</creatorcontrib><creatorcontrib>Yarali, Ziyşan Buse</creatorcontrib><creatorcontrib>Karaman, Ozan</creatorcontrib><creatorcontrib>Kantarci, Alpdoğan</creatorcontrib><creatorcontrib>Sağlam, Mehmet</creatorcontrib><creatorcontrib>Köseoğlu, Serhat</creatorcontrib><title>Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT).
Methods
The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method.
Results
There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) (
p
< 0.05), but no significant difference between groups in CAL. Clinical periodontal parameters improved in both study groups (
p
< 0.05). However, the gingival index (GI) and the bleeding on probing (BOP) rate decreased more in the test group (GI: 0.55, BOP: 9.48%, and GI: 0.38, BOP: 8.46% in the 1st and 3rd months, respectively) compared to the control group (GI: 0.68, BOP: 13.43%, and GI: 0.52, BOP: 14.58%) (
p
< 0.05). In addition, there was no significant difference in probing depth and biochemical markers between groups (
p
> 0.05). It was observed that NAPP reduced the number of bacteria more than the control group in the 1st and 3rd months.
Conclusions
It was seen that the single-time NAPP application concurrent with NSPT provided additional CAL gain, elimination of putative periodontopathogens and reduced their recolonization. Longitudinal studies with larger population and longer time are required.
Clinical relevance
NSPT is an effective method for the treatment of periodontitis but bacteria recolonization that causes recurrence of the periodontal disease occurs within a short period. NAPP can reduce the recurrence of periodontal disease by providing better bacterial elimination and should, therefore, be used in maintenance of periodontitis.</description><subject>Atmospheric pressure</subject><subject>Bacteria</subject><subject>Biochemical markers</subject><subject>Chronic Periodontitis - therapy</subject><subject>Clinical trials</subject><subject>Decontamination</subject><subject>Dental Plaque Index</subject><subject>Dental Scaling</subject><subject>Dentistry</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Follow-Up Studies</subject><subject>Gingiva</subject><subject>Gingival index</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Medicine</subject><subject>Original Article</subject><subject>Patients</subject><subject>Periodontal Attachment Loss</subject><subject>Periodontal diseases</subject><subject>Periodontitis</subject><subject>Periodontitis - therapy</subject><subject>Plasma Gases - therapeutic use</subject><subject>Polymerase chain reaction</subject><subject>Population studies</subject><subject>Recolonization</subject><subject>Root Planing</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc2OFSEQhYnROOPVF3BhSNy4QSngQrc7Mxl_kknczJ7QNCgTGlqgTcYX8LWl546auHADp6iv6pAchJ4DfQ2Uqje1H4MgFEZCOQyKsAfoHASXhCsFD-80I3Ic4Aw9qfWGUhBS8cforNOjUnQ4Rz8vv5u4mRZywtlj532wxt7uOuVE2ldXFhOxaUuuay-CxWtxtW7F4TWauhgcEm7FdcKlts-tncpzTi20UN9ig4tJc17CDzdj259LjnGXMaTuFftwMPEpeuRNrO7Z_X1A1-8vry8-kqvPHz5dvLsilqtjI_I4TiC8V3aSEqZpBKG4YY6zEbhn0vNhAitMb5qjmhkoMx1noJY7Mc4DP6BXp7Vryd82V5teQrUuRpNc3qpmnHNJlVKyoy__QW_yVlL_nGaCCxADg51iJ8qWXGtxXq8lLKbcaqB6T0mfUtI9JX2XUvc4oBf3q7dpcfOfkd-xdICfgNpb6Ysrf73_s_YXmGWfSg</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Küçük, Diğdem</creator><creator>Savran, Levent</creator><creator>Ercan, Utku Kürşat</creator><creator>Yarali, Ziyşan Buse</creator><creator>Karaman, Ozan</creator><creator>Kantarci, Alpdoğan</creator><creator>Sağlam, Mehmet</creator><creator>Köseoğlu, Serhat</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4121-2494</orcidid></search><sort><creationdate>20200901</creationdate><title>Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial</title><author>Küçük, Diğdem ; Savran, Levent ; Ercan, Utku Kürşat ; Yarali, Ziyşan Buse ; Karaman, Ozan ; Kantarci, Alpdoğan ; Sağlam, Mehmet ; Köseoğlu, Serhat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-659b14ff7cb661bb91473a2e32913f26f38b1c4a661a57d217ab5d10c3e49d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Atmospheric pressure</topic><topic>Bacteria</topic><topic>Biochemical markers</topic><topic>Chronic Periodontitis - therapy</topic><topic>Clinical trials</topic><topic>Decontamination</topic><topic>Dental Plaque Index</topic><topic>Dental Scaling</topic><topic>Dentistry</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Follow-Up Studies</topic><topic>Gingiva</topic><topic>Gingival index</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Medicine</topic><topic>Original Article</topic><topic>Patients</topic><topic>Periodontal Attachment Loss</topic><topic>Periodontal diseases</topic><topic>Periodontitis</topic><topic>Periodontitis - therapy</topic><topic>Plasma Gases - therapeutic use</topic><topic>Polymerase chain reaction</topic><topic>Population studies</topic><topic>Recolonization</topic><topic>Root Planing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Küçük, Diğdem</creatorcontrib><creatorcontrib>Savran, Levent</creatorcontrib><creatorcontrib>Ercan, Utku Kürşat</creatorcontrib><creatorcontrib>Yarali, Ziyşan Buse</creatorcontrib><creatorcontrib>Karaman, Ozan</creatorcontrib><creatorcontrib>Kantarci, Alpdoğan</creatorcontrib><creatorcontrib>Sağlam, Mehmet</creatorcontrib><creatorcontrib>Köseoğlu, Serhat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Küçük, Diğdem</au><au>Savran, Levent</au><au>Ercan, Utku Kürşat</au><au>Yarali, Ziyşan Buse</au><au>Karaman, Ozan</au><au>Kantarci, Alpdoğan</au><au>Sağlam, Mehmet</au><au>Köseoğlu, Serhat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>24</volume><issue>9</issue><spage>3133</spage><epage>3145</epage><pages>3133-3145</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT).
Methods
The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method.
Results
There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) (
p
< 0.05), but no significant difference between groups in CAL. Clinical periodontal parameters improved in both study groups (
p
< 0.05). However, the gingival index (GI) and the bleeding on probing (BOP) rate decreased more in the test group (GI: 0.55, BOP: 9.48%, and GI: 0.38, BOP: 8.46% in the 1st and 3rd months, respectively) compared to the control group (GI: 0.68, BOP: 13.43%, and GI: 0.52, BOP: 14.58%) (
p
< 0.05). In addition, there was no significant difference in probing depth and biochemical markers between groups (
p
> 0.05). It was observed that NAPP reduced the number of bacteria more than the control group in the 1st and 3rd months.
Conclusions
It was seen that the single-time NAPP application concurrent with NSPT provided additional CAL gain, elimination of putative periodontopathogens and reduced their recolonization. Longitudinal studies with larger population and longer time are required.
Clinical relevance
NSPT is an effective method for the treatment of periodontitis but bacteria recolonization that causes recurrence of the periodontal disease occurs within a short period. NAPP can reduce the recurrence of periodontal disease by providing better bacterial elimination and should, therefore, be used in maintenance of periodontitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31897708</pmid><doi>10.1007/s00784-019-03187-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4121-2494</orcidid></addata></record> |
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subjects | Atmospheric pressure Bacteria Biochemical markers Chronic Periodontitis - therapy Clinical trials Decontamination Dental Plaque Index Dental Scaling Dentistry Enzyme-linked immunosorbent assay Follow-Up Studies Gingiva Gingival index Gum disease Humans Medicine Original Article Patients Periodontal Attachment Loss Periodontal diseases Periodontitis Periodontitis - therapy Plasma Gases - therapeutic use Polymerase chain reaction Population studies Recolonization Root Planing |
title | Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial |
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