Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial

Objectives In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT). Methods The study included 25 systemically healthy...

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Veröffentlicht in:Clinical oral investigations 2020-09, Vol.24 (9), p.3133-3145
Hauptverfasser: Küçük, Diğdem, Savran, Levent, Ercan, Utku Kürşat, Yarali, Ziyşan Buse, Karaman, Ozan, Kantarci, Alpdoğan, Sağlam, Mehmet, Köseoğlu, Serhat
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container_issue 9
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container_title Clinical oral investigations
container_volume 24
creator Küçük, Diğdem
Savran, Levent
Ercan, Utku Kürşat
Yarali, Ziyşan Buse
Karaman, Ozan
Kantarci, Alpdoğan
Sağlam, Mehmet
Köseoğlu, Serhat
description Objectives In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT). Methods The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method. Results There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) ( p  
doi_str_mv 10.1007/s00784-019-03187-2
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Methods The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method. Results There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) ( p  &lt; 0.05), but no significant difference between groups in CAL. Clinical periodontal parameters improved in both study groups ( p  &lt; 0.05). However, the gingival index (GI) and the bleeding on probing (BOP) rate decreased more in the test group (GI: 0.55, BOP: 9.48%, and GI: 0.38, BOP: 8.46% in the 1st and 3rd months, respectively) compared to the control group (GI: 0.68, BOP: 13.43%, and GI: 0.52, BOP: 14.58%) ( p  &lt; 0.05). In addition, there was no significant difference in probing depth and biochemical markers between groups ( p  &gt; 0.05). It was observed that NAPP reduced the number of bacteria more than the control group in the 1st and 3rd months. Conclusions It was seen that the single-time NAPP application concurrent with NSPT provided additional CAL gain, elimination of putative periodontopathogens and reduced their recolonization. Longitudinal studies with larger population and longer time are required. Clinical relevance NSPT is an effective method for the treatment of periodontitis but bacteria recolonization that causes recurrence of the periodontal disease occurs within a short period. NAPP can reduce the recurrence of periodontal disease by providing better bacterial elimination and should, therefore, be used in maintenance of periodontitis.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-019-03187-2</identifier><identifier>PMID: 31897708</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atmospheric pressure ; Bacteria ; Biochemical markers ; Chronic Periodontitis - therapy ; Clinical trials ; Decontamination ; Dental Plaque Index ; Dental Scaling ; Dentistry ; Enzyme-linked immunosorbent assay ; Follow-Up Studies ; Gingiva ; Gingival index ; Gum disease ; Humans ; Medicine ; Original Article ; Patients ; Periodontal Attachment Loss ; Periodontal diseases ; Periodontitis ; Periodontitis - therapy ; Plasma Gases - therapeutic use ; Polymerase chain reaction ; Population studies ; Recolonization ; Root Planing</subject><ispartof>Clinical oral investigations, 2020-09, Vol.24 (9), p.3133-3145</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-659b14ff7cb661bb91473a2e32913f26f38b1c4a661a57d217ab5d10c3e49d83</citedby><cites>FETCH-LOGICAL-c375t-659b14ff7cb661bb91473a2e32913f26f38b1c4a661a57d217ab5d10c3e49d83</cites><orcidid>0000-0002-4121-2494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-019-03187-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-019-03187-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Küçük, Diğdem</creatorcontrib><creatorcontrib>Savran, Levent</creatorcontrib><creatorcontrib>Ercan, Utku Kürşat</creatorcontrib><creatorcontrib>Yarali, Ziyşan Buse</creatorcontrib><creatorcontrib>Karaman, Ozan</creatorcontrib><creatorcontrib>Kantarci, Alpdoğan</creatorcontrib><creatorcontrib>Sağlam, Mehmet</creatorcontrib><creatorcontrib>Köseoğlu, Serhat</creatorcontrib><title>Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives In this clinical study, we aim to evaluate the effectiveness of non-thermal atmospheric pressure plasma (NAPP), which is a novel procedure used in periodontal pocket decontamination adjunctive to non-surgical periodontal treatment (NSPT). Methods The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method. Results There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) ( p  &lt; 0.05), but no significant difference between groups in CAL. Clinical periodontal parameters improved in both study groups ( p  &lt; 0.05). However, the gingival index (GI) and the bleeding on probing (BOP) rate decreased more in the test group (GI: 0.55, BOP: 9.48%, and GI: 0.38, BOP: 8.46% in the 1st and 3rd months, respectively) compared to the control group (GI: 0.68, BOP: 13.43%, and GI: 0.52, BOP: 14.58%) ( p  &lt; 0.05). In addition, there was no significant difference in probing depth and biochemical markers between groups ( p  &gt; 0.05). It was observed that NAPP reduced the number of bacteria more than the control group in the 1st and 3rd months. Conclusions It was seen that the single-time NAPP application concurrent with NSPT provided additional CAL gain, elimination of putative periodontopathogens and reduced their recolonization. Longitudinal studies with larger population and longer time are required. Clinical relevance NSPT is an effective method for the treatment of periodontitis but bacteria recolonization that causes recurrence of the periodontal disease occurs within a short period. NAPP can reduce the recurrence of periodontal disease by providing better bacterial elimination and should, therefore, be used in maintenance of periodontitis.</description><subject>Atmospheric pressure</subject><subject>Bacteria</subject><subject>Biochemical markers</subject><subject>Chronic Periodontitis - therapy</subject><subject>Clinical trials</subject><subject>Decontamination</subject><subject>Dental Plaque Index</subject><subject>Dental Scaling</subject><subject>Dentistry</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Follow-Up Studies</subject><subject>Gingiva</subject><subject>Gingival index</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Medicine</subject><subject>Original Article</subject><subject>Patients</subject><subject>Periodontal Attachment Loss</subject><subject>Periodontal diseases</subject><subject>Periodontitis</subject><subject>Periodontitis - therapy</subject><subject>Plasma Gases - therapeutic use</subject><subject>Polymerase chain reaction</subject><subject>Population studies</subject><subject>Recolonization</subject><subject>Root Planing</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc2OFSEQhYnROOPVF3BhSNy4QSngQrc7Mxl_kknczJ7QNCgTGlqgTcYX8LWl546auHADp6iv6pAchJ4DfQ2Uqje1H4MgFEZCOQyKsAfoHASXhCsFD-80I3Ic4Aw9qfWGUhBS8cforNOjUnQ4Rz8vv5u4mRZywtlj532wxt7uOuVE2ldXFhOxaUuuay-CxWtxtW7F4TWauhgcEm7FdcKlts-tncpzTi20UN9ig4tJc17CDzdj259LjnGXMaTuFftwMPEpeuRNrO7Z_X1A1-8vry8-kqvPHz5dvLsilqtjI_I4TiC8V3aSEqZpBKG4YY6zEbhn0vNhAitMb5qjmhkoMx1noJY7Mc4DP6BXp7Vryd82V5teQrUuRpNc3qpmnHNJlVKyoy__QW_yVlL_nGaCCxADg51iJ8qWXGtxXq8lLKbcaqB6T0mfUtI9JX2XUvc4oBf3q7dpcfOfkd-xdICfgNpb6Ysrf73_s_YXmGWfSg</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Küçük, Diğdem</creator><creator>Savran, Levent</creator><creator>Ercan, Utku Kürşat</creator><creator>Yarali, Ziyşan Buse</creator><creator>Karaman, Ozan</creator><creator>Kantarci, Alpdoğan</creator><creator>Sağlam, Mehmet</creator><creator>Köseoğlu, Serhat</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4121-2494</orcidid></search><sort><creationdate>20200901</creationdate><title>Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial</title><author>Küçük, Diğdem ; 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Methods The study included 25 systemically healthy periodontitis patients. In the split-mouth design, NAPP application into the pockets, in addition to NSPT, was performed. Clinical periodontal data, gingival crevicular fluid, and subgingival plaque samples of patients were taken before and during the first and third months of treatment. Biochemical assays were conducted using enzyme-linked immunosorbent assay. Analysis of bacteria was performed with polymerase chain reaction method. Results There was more clinical attachment level (CAL) gain in the 3rd month in the test group (deep pockets: 3.90 mm, pockets ≥ 5 mm: 2.72 mm) compared to the control group (deep pockets: 3.40 mm, pockets ≥ 5 mm: 2.58 mm) ( p  &lt; 0.05), but no significant difference between groups in CAL. Clinical periodontal parameters improved in both study groups ( p  &lt; 0.05). However, the gingival index (GI) and the bleeding on probing (BOP) rate decreased more in the test group (GI: 0.55, BOP: 9.48%, and GI: 0.38, BOP: 8.46% in the 1st and 3rd months, respectively) compared to the control group (GI: 0.68, BOP: 13.43%, and GI: 0.52, BOP: 14.58%) ( p  &lt; 0.05). In addition, there was no significant difference in probing depth and biochemical markers between groups ( p  &gt; 0.05). It was observed that NAPP reduced the number of bacteria more than the control group in the 1st and 3rd months. Conclusions It was seen that the single-time NAPP application concurrent with NSPT provided additional CAL gain, elimination of putative periodontopathogens and reduced their recolonization. Longitudinal studies with larger population and longer time are required. Clinical relevance NSPT is an effective method for the treatment of periodontitis but bacteria recolonization that causes recurrence of the periodontal disease occurs within a short period. NAPP can reduce the recurrence of periodontal disease by providing better bacterial elimination and should, therefore, be used in maintenance of periodontitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31897708</pmid><doi>10.1007/s00784-019-03187-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4121-2494</orcidid></addata></record>
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subjects Atmospheric pressure
Bacteria
Biochemical markers
Chronic Periodontitis - therapy
Clinical trials
Decontamination
Dental Plaque Index
Dental Scaling
Dentistry
Enzyme-linked immunosorbent assay
Follow-Up Studies
Gingiva
Gingival index
Gum disease
Humans
Medicine
Original Article
Patients
Periodontal Attachment Loss
Periodontal diseases
Periodontitis
Periodontitis - therapy
Plasma Gases - therapeutic use
Polymerase chain reaction
Population studies
Recolonization
Root Planing
title Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial
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