Isoliquiritigenin triggers developmental toxicity and oxidative stress–mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway

Isoliquiritigenin (ISL) is an emerging natural flavonoid found in the roots of licorice, exhibits antioxidant, anti-cancer, anti-inflammatory, anti-allergic, cardioprotective, hepatoprotective and neuroprotective properties. However, the effect of ISL in embryonic development is yet to be elucidated...

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Veröffentlicht in:	Chemosphere (Oxford) 2020-05, Vol.246, p.125727-125727, Article 125727
Hauptverfasser:	Song, Zhenzhen, Zhang, Yun, Zhang, Huazheng, Rajendran, R. Samuel, Wang, Rongchun, Hsiao, Chung-Der, Li, Jianheng, Xia, Qing, Liu, Kechun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Chalcones - toxicity Developmental toxicity Embryo, Nonmammalian - drug effects Enzyme Inhibitors - toxicity Isoliquiritigenin Larva - metabolism MAP Kinase Signaling System - drug effects Mitochondria - metabolism NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Zebrafish Zebrafish - embryology Zebrafish - metabolism
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