Unlocking the potential antioxidant and anti-inflammatory activities of Rhododendron molle G. Don
Rhododendron molle G. Don is an important traditional Chinese medicinal plant, which has been applied to treat some inflammatory diseases. In the present study, ethanol extracts of R. molle flower (RFE) and leaf (RLE) were used for phytochemical, antioxidant and anti-inflammatory analysis. The antio...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2019-09, Vol.32 (5(Special)), p.2375-2383 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Zhang, Jin Liu, Jian Dai, Liang Fang Zhang, Hong Yi Chen, Min Na Cai, Xian Feng Xie, Jian Kun Luo, Xiang Dong |
| description | Rhododendron molle G. Don is an important traditional Chinese medicinal plant, which has been applied to treat some inflammatory diseases. In the present study, ethanol extracts of R. molle flower (RFE) and leaf (RLE) were used for phytochemical, antioxidant and anti-inflammatory analysis. The antioxidant activity was investigated using the free radicals of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical (OH-)-scavenging activity, super oxide anion radical (O2.-)-scavenging activity and iron reducing power (FRAP). Production of nitric oxide (NO) was an indicator to evaluate the anti-inflammatory activity. The results showed that compared with RFE, RLE was more active against DPPH (56.66%), FRAP (51.29%) and hydroxyl radical (OH-) (69.66%) at 100μg/mL. In the same time, RLE and RFE had significant anti-inflammatory activity which could reduce nitrite production from 8.76μM to 5.08μM and 6.01μM, respectively. In addition, GC-MS analysis showed that 43 compounds were identified in R. molle. Among them, 11 compounds had antioxidant and 5 compounds had anti-inflammatory effect. Results showed that ethanol extracts of R. molle have significant antioxidant and anti-inflammatory activity. These results would be helpful for further investigation on the anti-inflammatory mechanism of R. molle. |
| format | Article |
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Don</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Zhang, Jin ; Liu, Jian ; Dai, Liang Fang ; Zhang, Hong Yi ; Chen, Min Na ; Cai, Xian Feng ; Xie, Jian Kun ; Luo, Xiang Dong</creator><creatorcontrib>Zhang, Jin ; Liu, Jian ; Dai, Liang Fang ; Zhang, Hong Yi ; Chen, Min Na ; Cai, Xian Feng ; Xie, Jian Kun ; Luo, Xiang Dong</creatorcontrib><description>Rhododendron molle G. Don is an important traditional Chinese medicinal plant, which has been applied to treat some inflammatory diseases. In the present study, ethanol extracts of R. molle flower (RFE) and leaf (RLE) were used for phytochemical, antioxidant and anti-inflammatory analysis. The antioxidant activity was investigated using the free radicals of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical (OH-)-scavenging activity, super oxide anion radical (O2.-)-scavenging activity and iron reducing power (FRAP). Production of nitric oxide (NO) was an indicator to evaluate the anti-inflammatory activity. The results showed that compared with RFE, RLE was more active against DPPH (56.66%), FRAP (51.29%) and hydroxyl radical (OH-) (69.66%) at 100μg/mL. In the same time, RLE and RFE had significant anti-inflammatory activity which could reduce nitrite production from 8.76μM to 5.08μM and 6.01μM, respectively. In addition, GC-MS analysis showed that 43 compounds were identified in R. molle. Among them, 11 compounds had antioxidant and 5 compounds had anti-inflammatory effect. Results showed that ethanol extracts of R. molle have significant antioxidant and anti-inflammatory activity. These results would be helpful for further investigation on the anti-inflammatory mechanism of R. molle.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 31894021</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Analysis ; Anti-inflammatory agents ; Antioxidants (Nutrients) ; Biphenyl (Compound) ; EDTA ; Ethanol ; Free radicals ; Herbal medicine ; Hydroxides ; Inflammation ; Medical research ; Medicinal plants ; Nitric oxide ; Nitrogen oxides</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2019-09, Vol.32 (5(Special)), p.2375-2383</ispartof><rights>COPYRIGHT 2019 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31894021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jin</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Dai, Liang Fang</creatorcontrib><creatorcontrib>Zhang, Hong Yi</creatorcontrib><creatorcontrib>Chen, Min Na</creatorcontrib><creatorcontrib>Cai, Xian Feng</creatorcontrib><creatorcontrib>Xie, Jian Kun</creatorcontrib><creatorcontrib>Luo, Xiang Dong</creatorcontrib><title>Unlocking the potential antioxidant and anti-inflammatory activities of Rhododendron molle G. Don</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Rhododendron molle G. Don is an important traditional Chinese medicinal plant, which has been applied to treat some inflammatory diseases. In the present study, ethanol extracts of R. molle flower (RFE) and leaf (RLE) were used for phytochemical, antioxidant and anti-inflammatory analysis. The antioxidant activity was investigated using the free radicals of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical (OH-)-scavenging activity, super oxide anion radical (O2.-)-scavenging activity and iron reducing power (FRAP). Production of nitric oxide (NO) was an indicator to evaluate the anti-inflammatory activity. The results showed that compared with RFE, RLE was more active against DPPH (56.66%), FRAP (51.29%) and hydroxyl radical (OH-) (69.66%) at 100μg/mL. In the same time, RLE and RFE had significant anti-inflammatory activity which could reduce nitrite production from 8.76μM to 5.08μM and 6.01μM, respectively. In addition, GC-MS analysis showed that 43 compounds were identified in R. molle. Among them, 11 compounds had antioxidant and 5 compounds had anti-inflammatory effect. Results showed that ethanol extracts of R. molle have significant antioxidant and anti-inflammatory activity. These results would be helpful for further investigation on the anti-inflammatory mechanism of R. molle.</description><subject>Analysis</subject><subject>Anti-inflammatory agents</subject><subject>Antioxidants (Nutrients)</subject><subject>Biphenyl (Compound)</subject><subject>EDTA</subject><subject>Ethanol</subject><subject>Free radicals</subject><subject>Herbal medicine</subject><subject>Hydroxides</subject><subject>Inflammation</subject><subject>Medical research</subject><subject>Medicinal plants</subject><subject>Nitric oxide</subject><subject>Nitrogen oxides</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNo1kE9PwzAMxXsAsTH4CihHLp1ip-2aI-K_NAkJMYlb5SbpFkiT0WaIfXsiNuTDz896fpJ9kk2BA-QVh_dJdj6OH5xXhZTyLJsIqGXBEaYZrbwL6tP6NYsbw7YhGh8tOUYJ4cfqxNTrP51b3znqe4ph2DNS0X7baM3IQsdeN0EHbbwegmd9cM6wxzm7C_4iO-3IjebyyFm2erh_u33Kly-Pz7c3y3yNJY95IWplirLUQABYtbTodIslLYiwlZwDbwGx5dgWCETQyVqBQuQVQkVSill2fcjdDuFrZ8bY9HZUxjnyJuzGBoVAXmMtMFnnB-uanGnSUSEOpFJp01sVvOlsmt9UvK6gkKVIC1fH7F3bG91sB9vTsG_-_yh-AZYqbbk</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Zhang, Jin</creator><creator>Liu, Jian</creator><creator>Dai, Liang Fang</creator><creator>Zhang, Hong Yi</creator><creator>Chen, Min Na</creator><creator>Cai, Xian Feng</creator><creator>Xie, Jian Kun</creator><creator>Luo, Xiang Dong</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Unlocking the potential antioxidant and anti-inflammatory activities of Rhododendron molle G. Don</title><author>Zhang, Jin ; Liu, Jian ; Dai, Liang Fang ; Zhang, Hong Yi ; Chen, Min Na ; Cai, Xian Feng ; Xie, Jian Kun ; Luo, Xiang Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g250t-438ce455d1a1126ba7fdb25a7aa2b90010b122b02b421aa1f98c1c2206216a993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Anti-inflammatory agents</topic><topic>Antioxidants (Nutrients)</topic><topic>Biphenyl (Compound)</topic><topic>EDTA</topic><topic>Ethanol</topic><topic>Free radicals</topic><topic>Herbal medicine</topic><topic>Hydroxides</topic><topic>Inflammation</topic><topic>Medical research</topic><topic>Medicinal plants</topic><topic>Nitric oxide</topic><topic>Nitrogen oxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jin</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Dai, Liang Fang</creatorcontrib><creatorcontrib>Zhang, Hong Yi</creatorcontrib><creatorcontrib>Chen, Min Na</creatorcontrib><creatorcontrib>Cai, Xian Feng</creatorcontrib><creatorcontrib>Xie, Jian Kun</creatorcontrib><creatorcontrib>Luo, Xiang Dong</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jin</au><au>Liu, Jian</au><au>Dai, Liang Fang</au><au>Zhang, Hong Yi</au><au>Chen, Min Na</au><au>Cai, Xian Feng</au><au>Xie, Jian Kun</au><au>Luo, Xiang Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unlocking the potential antioxidant and anti-inflammatory activities of Rhododendron molle G. Don</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>32</volume><issue>5(Special)</issue><spage>2375</spage><epage>2383</epage><pages>2375-2383</pages><issn>1011-601X</issn><abstract>Rhododendron molle G. Don is an important traditional Chinese medicinal plant, which has been applied to treat some inflammatory diseases. In the present study, ethanol extracts of R. molle flower (RFE) and leaf (RLE) were used for phytochemical, antioxidant and anti-inflammatory analysis. The antioxidant activity was investigated using the free radicals of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical (OH-)-scavenging activity, super oxide anion radical (O2.-)-scavenging activity and iron reducing power (FRAP). Production of nitric oxide (NO) was an indicator to evaluate the anti-inflammatory activity. The results showed that compared with RFE, RLE was more active against DPPH (56.66%), FRAP (51.29%) and hydroxyl radical (OH-) (69.66%) at 100μg/mL. In the same time, RLE and RFE had significant anti-inflammatory activity which could reduce nitrite production from 8.76μM to 5.08μM and 6.01μM, respectively. In addition, GC-MS analysis showed that 43 compounds were identified in R. molle. Among them, 11 compounds had antioxidant and 5 compounds had anti-inflammatory effect. Results showed that ethanol extracts of R. molle have significant antioxidant and anti-inflammatory activity. These results would be helpful for further investigation on the anti-inflammatory mechanism of R. molle.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>31894021</pmid><tpages>9</tpages></addata></record> |
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| subjects | Analysis Anti-inflammatory agents Antioxidants (Nutrients) Biphenyl (Compound) EDTA Ethanol Free radicals Herbal medicine Hydroxides Inflammation Medical research Medicinal plants Nitric oxide Nitrogen oxides |
| title | Unlocking the potential antioxidant and anti-inflammatory activities of Rhododendron molle G. Don |
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