A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137
Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) me...
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| creator | Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting |
| description | Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine
Verrucosispora
sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (
1
), together with six known abyssomicin and proximicin analogs (
2
–
7
). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds
1
–
3
showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 μM, and they displayed lower cytotoxicity than
4
. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites. |
| doi_str_mv | 10.1007/s00253-019-10217-2 |
| format | Article |
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Verrucosispora
sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (
1
), together with six known abyssomicin and proximicin analogs (
2
–
7
). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds
1
–
3
showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 μM, and they displayed lower cytotoxicity than
4
. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-019-10217-2</identifier><identifier>PMID: 31894364</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Actinomycetes ; Antiviral agents ; Biological activity ; Biomedical and Life Sciences ; Biotechnological Products and Process Engineering ; Biotechnology ; Control ; Cytotoxicity ; Health aspects ; Influenza ; Influenza A ; Influenza viruses ; Life Sciences ; Liquid chromatography ; Marine bacteria ; Marine microorganisms ; Mass spectrometry ; Mass spectroscopy ; Metabolites ; Microbial Genetics and Genomics ; Microbiology ; Microorganisms ; Natural products ; NMR ; Nuclear magnetic resonance ; Physiological aspects ; Polyketides ; Secondary metabolites ; Testing ; Toxicity ; Transcription activation ; Viruses</subject><ispartof>Applied microbiology and biotechnology, 2020-02, Vol.104 (4), p.1533-1543</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-9c2f16fb6d7d6ddd8fd21ecfcf0975369b71eeaf8432f043c5e1e8ebe8bccd3a3</citedby><cites>FETCH-LOGICAL-c513t-9c2f16fb6d7d6ddd8fd21ecfcf0975369b71eeaf8432f043c5e1e8ebe8bccd3a3</cites><orcidid>0000-0001-6581-6818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-019-10217-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-019-10217-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31894364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jingyu</creatorcontrib><creatorcontrib>Li, Bixiao</creatorcontrib><creatorcontrib>Qin, Yujie</creatorcontrib><creatorcontrib>Karthik, Loganathan</creatorcontrib><creatorcontrib>Zhu, Guoliang</creatorcontrib><creatorcontrib>Hou, Chengjian</creatorcontrib><creatorcontrib>Jiang, Lan</creatorcontrib><creatorcontrib>Liu, Miaomiao</creatorcontrib><creatorcontrib>Ye, Xin</creatorcontrib><creatorcontrib>Liu, Mei</creatorcontrib><creatorcontrib>Hsiang, Tom</creatorcontrib><creatorcontrib>Dai, Huanqin</creatorcontrib><creatorcontrib>Zhang, Lixin</creatorcontrib><creatorcontrib>Liu, Xueting</creatorcontrib><title>A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine
Verrucosispora
sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (
1
), together with six known abyssomicin and proximicin analogs (
2
–
7
). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds
1
–
3
showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 μM, and they displayed lower cytotoxicity than
4
. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.</description><subject>Actinomycetes</subject><subject>Antiviral agents</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnological Products and Process Engineering</subject><subject>Biotechnology</subject><subject>Control</subject><subject>Cytotoxicity</subject><subject>Health aspects</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza viruses</subject><subject>Life Sciences</subject><subject>Liquid chromatography</subject><subject>Marine bacteria</subject><subject>Marine microorganisms</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolites</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Natural products</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Physiological aspects</subject><subject>Polyketides</subject><subject>Secondary metabolites</subject><subject>Testing</subject><subject>Toxicity</subject><subject>Transcription activation</subject><subject>Viruses</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl9rFDEUxYModl39Aj5IwBd9yJo_M5mZx6VULVQEq76GTHKzps4kazKzdf30pm6trIjkIZD8zuWew0HoKaMrRmnzKlPKa0Eo6wijnDWE30MLVglOqGTVfbSgrKlJU3ftCXqU8xWljLdSPkQngrVdJWS1QHmNA1xj3e9zjqM3PuBtHPZfYfIW8LWfvmAdJk98cMMM4YfGa7zzac5Ym8nv_LTHLsURazzq5AMQC8nvwOLPkNJsYvZ5G5PGebvC7y7L2kw0j9EDp4cMT27vJfr0-uzj6Vty8f7N-en6gpiaiYl0hjsmXS9tY6W1tnWWMzDOONo1tZBd3zAA7dri2NFKmBoYtNBD2xtjhRZL9OIwd5vitxnypEafDQyDDhDnrLgQnLYluLqgz_9Cr-KcQtmuUJXkspaFvqM2egBVIolT0uZmqFpLxmvGSvqFWv2DKsdCCTgGcL68HwleHgkKM8H3aaPnnNX55Ydjlh9Yk2LOCZzaJl-i3ytG1U0r1KEVqrRC_WpFMbBEz27dzf0I9k7yuwYFEAcgl6-wgfTH_n_G_gQ_CcCE</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Zhang, Jingyu</creator><creator>Li, Bixiao</creator><creator>Qin, Yujie</creator><creator>Karthik, Loganathan</creator><creator>Zhu, Guoliang</creator><creator>Hou, Chengjian</creator><creator>Jiang, Lan</creator><creator>Liu, Miaomiao</creator><creator>Ye, Xin</creator><creator>Liu, Mei</creator><creator>Hsiang, Tom</creator><creator>Dai, Huanqin</creator><creator>Zhang, Lixin</creator><creator>Liu, Xueting</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6581-6818</orcidid></search><sort><creationdate>20200201</creationdate><title>A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137</title><author>Zhang, Jingyu ; Li, Bixiao ; Qin, Yujie ; Karthik, Loganathan ; Zhu, Guoliang ; Hou, Chengjian ; Jiang, Lan ; Liu, Miaomiao ; Ye, Xin ; Liu, Mei ; Hsiang, Tom ; Dai, Huanqin ; Zhang, Lixin ; Liu, Xueting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-9c2f16fb6d7d6ddd8fd21ecfcf0975369b71eeaf8432f043c5e1e8ebe8bccd3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Actinomycetes</topic><topic>Antiviral agents</topic><topic>Biological activity</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnological Products and Process Engineering</topic><topic>Biotechnology</topic><topic>Control</topic><topic>Cytotoxicity</topic><topic>Health aspects</topic><topic>Influenza</topic><topic>Influenza A</topic><topic>Influenza viruses</topic><topic>Life Sciences</topic><topic>Liquid chromatography</topic><topic>Marine 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Xin</au><au>Liu, Mei</au><au>Hsiang, Tom</au><au>Dai, Huanqin</au><au>Zhang, Lixin</au><au>Liu, Xueting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>104</volume><issue>4</issue><spage>1533</spage><epage>1543</epage><pages>1533-1543</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine
Verrucosispora
sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (
1
), together with six known abyssomicin and proximicin analogs (
2
–
7
). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds
1
–
3
showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 μM, and they displayed lower cytotoxicity than
4
. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31894364</pmid><doi>10.1007/s00253-019-10217-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6581-6818</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2020-02, Vol.104 (4), p.1533-1543 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2332082175 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Actinomycetes Antiviral agents Biological activity Biomedical and Life Sciences Biotechnological Products and Process Engineering Biotechnology Control Cytotoxicity Health aspects Influenza Influenza A Influenza viruses Life Sciences Liquid chromatography Marine bacteria Marine microorganisms Mass spectrometry Mass spectroscopy Metabolites Microbial Genetics and Genomics Microbiology Microorganisms Natural products NMR Nuclear magnetic resonance Physiological aspects Polyketides Secondary metabolites Testing Toxicity Transcription activation Viruses |
| title | A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137 |
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