MiR-203 regulates estrogen receptor α and cartilage degradation in IL-1β-stimulated chondrocytes

Introduction Estrogen receptor α (ERα) plays important roles in the etiology of osteoarthritis (OA), in which cartilage degradation and cellular inflammation are involved. MiR-203 is reported to direct target ERα, but its roles in chondrocytes remain uncovered. Methods In this study, ELISA showed th...

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Veröffentlicht in:	Journal of bone and mineral metabolism 2020-05, Vol.38 (3), p.346-356
Hauptverfasser:	Guo, Yusong, Tian, Lijun, Du, Xiqiao, Deng, Zhigang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecan Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell injury Cell viability Cells, Cultured Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Down-regulation Enzyme-linked immunosorbent assay Estrogen Receptor alpha - metabolism Etiology Female Humans IL-1β Inflammation Inflammation - genetics Inflammation - pathology Interleukin-1beta - pharmacology Medicine Medicine & Public Health Metabolic Diseases MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Original Article Orthopedics Osteoarthritis Osteoarthritis - genetics Osteoarthritis - pathology Polymerase chain reaction Post-menopause siRNA Therapeutic applications Western blotting
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