Macrosomia and psychiatric risk in adolescence

The prenatal environment can exert important effects on mental health. While much research has linked low birth weight to psychopathology, the intrauterine environment associated with high birth weight (macrosomia; > 4000 g) is also sub-optimal and may increase risk. Given the increasing prevalen...

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Veröffentlicht in:European child & adolescent psychiatry 2020-11, Vol.29 (11), p.1537-1545
Hauptverfasser: Van Lieshout, Ryan J., Savoy, Calan D., Ferro, Mark A., Krzeczkowski, John E., Colman, Ian
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container_issue 11
container_start_page 1537
container_title European child & adolescent psychiatry
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creator Van Lieshout, Ryan J.
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Krzeczkowski, John E.
Colman, Ian
description The prenatal environment can exert important effects on mental health. While much research has linked low birth weight to psychopathology, the intrauterine environment associated with high birth weight (macrosomia; > 4000 g) is also sub-optimal and may increase risk. Given the increasing prevalence of macrosomic births, understanding the mental health outcomes of infants born macrosomic can help refine theories of etiology, predict disorder, and target preventive interventions. Using data from the 2014 Ontario Child Health Study (OCHS), we examined the risk for psychiatric disorders in adolescents born macrosomic. Youth ( N  = 2151) aged 12–17 years completed the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). Rates of common mental disorders assessed by the MINI-KID were compared between those born at normal birth weight (NBW; 2500–4000 g, n  = 1817) and adolescents born macrosomic (> 4000 g, n  = 334). These associations were then adjusted for participant age, sex, socioeconomic status (SES) of the family, parental mental health, and gestational diabetes mellitus. After adjustment for covariates, adolescents born macrosomic had higher odds of conduct disorder (CD; OR = 3.19, 95% CI: 1.37–7.43), oppositional defiant disorder (ODD; OR = 1.79, 95% CI: 1.11–2.91), and ADHD (OR = 1.77, 95% CI: 1.21–2.80). Moderation analyses revealed that males born macrosomic were more likely to have psychiatric problems than their female peers. Socioeconomic disadvantage also amplified the risk posed by macrosomia for ODD, ADHD, major depressive disorder, and generalized anxiety disorder. In this study, macrosomia was associated with an increased risk of clinically significant externalizing problems in adolescence, most notably among boys and those facing socioeconomic disadvantage.
doi_str_mv 10.1007/s00787-019-01466-7
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While much research has linked low birth weight to psychopathology, the intrauterine environment associated with high birth weight (macrosomia; &gt; 4000 g) is also sub-optimal and may increase risk. Given the increasing prevalence of macrosomic births, understanding the mental health outcomes of infants born macrosomic can help refine theories of etiology, predict disorder, and target preventive interventions. Using data from the 2014 Ontario Child Health Study (OCHS), we examined the risk for psychiatric disorders in adolescents born macrosomic. Youth ( N  = 2151) aged 12–17 years completed the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). Rates of common mental disorders assessed by the MINI-KID were compared between those born at normal birth weight (NBW; 2500–4000 g, n  = 1817) and adolescents born macrosomic (&gt; 4000 g, n  = 334). 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adolescent psychiatry</jtitle><stitle>Eur Child Adolesc Psychiatry</stitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>29</volume><issue>11</issue><spage>1537</spage><epage>1545</epage><pages>1537-1545</pages><issn>1018-8827</issn><eissn>1435-165X</eissn><abstract>The prenatal environment can exert important effects on mental health. While much research has linked low birth weight to psychopathology, the intrauterine environment associated with high birth weight (macrosomia; &gt; 4000 g) is also sub-optimal and may increase risk. Given the increasing prevalence of macrosomic births, understanding the mental health outcomes of infants born macrosomic can help refine theories of etiology, predict disorder, and target preventive interventions. Using data from the 2014 Ontario Child Health Study (OCHS), we examined the risk for psychiatric disorders in adolescents born macrosomic. Youth ( N  = 2151) aged 12–17 years completed the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). Rates of common mental disorders assessed by the MINI-KID were compared between those born at normal birth weight (NBW; 2500–4000 g, n  = 1817) and adolescents born macrosomic (&gt; 4000 g, n  = 334). These associations were then adjusted for participant age, sex, socioeconomic status (SES) of the family, parental mental health, and gestational diabetes mellitus. After adjustment for covariates, adolescents born macrosomic had higher odds of conduct disorder (CD; OR = 3.19, 95% CI: 1.37–7.43), oppositional defiant disorder (ODD; OR = 1.79, 95% CI: 1.11–2.91), and ADHD (OR = 1.77, 95% CI: 1.21–2.80). Moderation analyses revealed that males born macrosomic were more likely to have psychiatric problems than their female peers. Socioeconomic disadvantage also amplified the risk posed by macrosomia for ODD, ADHD, major depressive disorder, and generalized anxiety disorder. In this study, macrosomia was associated with an increased risk of clinically significant externalizing problems in adolescence, most notably among boys and those facing socioeconomic disadvantage.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31894421</pmid><doi>10.1007/s00787-019-01466-7</doi><tpages>9</tpages></addata></record>
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subjects Adolescence
Adolescents
Anxiety disorders
Attention deficit hyperactivity disorder
Birth weight
Births
Child & adolescent psychiatry
Child and Adolescent Psychiatry
Child development
Childbirth & labor
Childrens health
Clinical significance
Conduct disorder
Depressive personality disorders
Diabetes mellitus
Etiology
Externalizing problems
Generalized anxiety disorder
Gestational diabetes
Health status
Infants
Intrauterine exposure
Low birth weight
Males
Medicine
Medicine & Public Health
Men
Mental depression
Mental disorders
Mental health
Moderation
Oppositional defiant disorder
Original Contribution
Prenatal care
Psychiatry
Psychopathology
Socioeconomic factors
Socioeconomic status
Teenagers
title Macrosomia and psychiatric risk in adolescence
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