DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN

•DJ-1-binding compound B stimulated oxidative stress-induced transcriptional activity of Nrf2.•Stimulation of Nrf2 activity by compound B was caused by inhibition of Nrf2 degradation.•Stimulation occurs in a PTEN but not Keap1-dependent manner.•Stimulation is due to activation of the PI3K/Akt signal...

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Veröffentlicht in:	Brain research 2020-02, Vol.1729, p.146641-146641, Article 146641
Hauptverfasser:	Niki, Takeshi, Endo, Jinro, Takahashi-Niki, Kazuko, Yasuda, Tatsuki, Okamoto, Asami, Saito, Yoshiro, Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	DJ-1 DJ-1-binding compound Keap1 Nrf2 Oxidative stress Parkinson’s disease PI3K/Akt
Online-Zugang:	Volltext
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