N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation
[Display omitted] •Chitosan was modified with isopropyl side chains on the amino groups.•N-isopropyl chitosan shows altered hydrophobic/hydrophilic features.•N-isopropyl chitosan is pH- and thermo- responsive in hydrogel formation.•The modified polysaccharide did not show any cytotoxicity. The prese...
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| Veröffentlicht in: | Carbohydrate polymers 2020-02, Vol.230, p.115641-115641, Article 115641 |
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| container_title | Carbohydrate polymers |
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| creator | Cok, Michela Viola, Marco Vecchies, Federica Sacco, Pasquale Furlani, Franco Marsich, Eleonora Donati, Ivan |
| description | [Display omitted]
•Chitosan was modified with isopropyl side chains on the amino groups.•N-isopropyl chitosan shows altered hydrophobic/hydrophilic features.•N-isopropyl chitosan is pH- and thermo- responsive in hydrogel formation.•The modified polysaccharide did not show any cytotoxicity.
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments. |
| doi_str_mv | 10.1016/j.carbpol.2019.115641 |
| format | Article |
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•Chitosan was modified with isopropyl side chains on the amino groups.•N-isopropyl chitosan shows altered hydrophobic/hydrophilic features.•N-isopropyl chitosan is pH- and thermo- responsive in hydrogel formation.•The modified polysaccharide did not show any cytotoxicity.
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2019.115641</identifier><identifier>PMID: 31887884</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Hydrogel formation ; N-isopropyl modified chitosan ; pH-stimulus ; Rheology ; Thermal stimulus</subject><ispartof>Carbohydrate polymers, 2020-02, Vol.230, p.115641-115641, Article 115641</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-a6ce08a918297a649dc6df0e1de3f3797ce30f9097e3090537befef0d41f303e3</citedby><cites>FETCH-LOGICAL-c449t-a6ce08a918297a649dc6df0e1de3f3797ce30f9097e3090537befef0d41f303e3</cites><orcidid>0000-0001-5986-1727 ; 0000-0003-3752-8346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861719313098$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31887884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cok, Michela</creatorcontrib><creatorcontrib>Viola, Marco</creatorcontrib><creatorcontrib>Vecchies, Federica</creatorcontrib><creatorcontrib>Sacco, Pasquale</creatorcontrib><creatorcontrib>Furlani, Franco</creatorcontrib><creatorcontrib>Marsich, Eleonora</creatorcontrib><creatorcontrib>Donati, Ivan</creatorcontrib><title>N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>[Display omitted]
•Chitosan was modified with isopropyl side chains on the amino groups.•N-isopropyl chitosan shows altered hydrophobic/hydrophilic features.•N-isopropyl chitosan is pH- and thermo- responsive in hydrogel formation.•The modified polysaccharide did not show any cytotoxicity.
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments.</description><subject>Hydrogel formation</subject><subject>N-isopropyl modified chitosan</subject><subject>pH-stimulus</subject><subject>Rheology</subject><subject>Thermal stimulus</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkMFOwzAQRC0EoqXwCaAcuSR4YzeJT6hCQJEqkBCcLddeU1dJHOy0Uv-eVC1c2ctcZnZ2HyHXQDOgUNytM63CsvN1llMQGcC04HBCxlCVIgXG-SkZU-A8rQooR-QixjUdpgB6TkYMqqqsKj4m76-pi74LvtvViV653kfVZsks6eZpolqT9CsMjU8Dxs630W0xGTp3UWm9UsEZTKwPyRfWe21U73x7Sc6sqiNeHXVCPp8ePx7m6eLt-eVhtkg156JPVaGRVkpAlYtSFVwYXRhLEQwyy0pRamTUCirKQQWdsnKJFi01HCyjDNmE3B72Dtd_bzD2snFRY12rFv0mypwxKNiUQT5YpwerDj7GgFZ2wTUq7CRQuccp1_KIU-5xygPOIXdzrNgsGzR_qV9-g-H-YMDh0a3DIKN22Go0LqDupfHun4ofSUWJBw</recordid><startdate>20200215</startdate><enddate>20200215</enddate><creator>Cok, Michela</creator><creator>Viola, Marco</creator><creator>Vecchies, Federica</creator><creator>Sacco, Pasquale</creator><creator>Furlani, Franco</creator><creator>Marsich, Eleonora</creator><creator>Donati, Ivan</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5986-1727</orcidid><orcidid>https://orcid.org/0000-0003-3752-8346</orcidid></search><sort><creationdate>20200215</creationdate><title>N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation</title><author>Cok, Michela ; Viola, Marco ; Vecchies, Federica ; Sacco, Pasquale ; Furlani, Franco ; Marsich, Eleonora ; Donati, Ivan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-a6ce08a918297a649dc6df0e1de3f3797ce30f9097e3090537befef0d41f303e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Hydrogel formation</topic><topic>N-isopropyl modified chitosan</topic><topic>pH-stimulus</topic><topic>Rheology</topic><topic>Thermal stimulus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cok, Michela</creatorcontrib><creatorcontrib>Viola, Marco</creatorcontrib><creatorcontrib>Vecchies, Federica</creatorcontrib><creatorcontrib>Sacco, Pasquale</creatorcontrib><creatorcontrib>Furlani, Franco</creatorcontrib><creatorcontrib>Marsich, Eleonora</creatorcontrib><creatorcontrib>Donati, Ivan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cok, Michela</au><au>Viola, Marco</au><au>Vecchies, Federica</au><au>Sacco, Pasquale</au><au>Furlani, Franco</au><au>Marsich, Eleonora</au><au>Donati, Ivan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2020-02-15</date><risdate>2020</risdate><volume>230</volume><spage>115641</spage><epage>115641</epage><pages>115641-115641</pages><artnum>115641</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>[Display omitted]
•Chitosan was modified with isopropyl side chains on the amino groups.•N-isopropyl chitosan shows altered hydrophobic/hydrophilic features.•N-isopropyl chitosan is pH- and thermo- responsive in hydrogel formation.•The modified polysaccharide did not show any cytotoxicity.
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31887884</pmid><doi>10.1016/j.carbpol.2019.115641</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5986-1727</orcidid><orcidid>https://orcid.org/0000-0003-3752-8346</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Carbohydrate polymers, 2020-02, Vol.230, p.115641-115641, Article 115641 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Hydrogel formation N-isopropyl modified chitosan pH-stimulus Rheology Thermal stimulus |
| title | N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation |
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