Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion
Stiffness plays an important role in diagnosing renal fibrosis. However, kidney stiffness is altered by perfusion changes in many kidney diseases. Therefore, the aim of the current study is to determine the correlation of kidney stiffness with water intake. We hypothesize that kidney stiffness will...
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| Veröffentlicht in: | NMR in biomedicine 2020-04, Vol.33 (4), p.e4237-n/a |
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| description | Stiffness plays an important role in diagnosing renal fibrosis. However, kidney stiffness is altered by perfusion changes in many kidney diseases. Therefore, the aim of the current study is to determine the correlation of kidney stiffness with water intake. We hypothesize that kidney stiffness will increase with 1 L of water intake due to increased water perfusion to the kidneys. Additionally, stiffness of the kidneys will correlate with apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values before and after water intake. A 3 T MRI scanner was used to perform magnetic resonance elastography and diffusion tensor imaging of the kidneys on 24 healthy subjects (age range: 22‐66 years) before and after water intake of 1 L. A 3D T1‐weighted bladder scan was also performed to measure bladder volume before and after water intake. A paired t‐test was performed to evaluate the effect of water intake on the stiffness of kidneys, in addition to bladder volume. A Spearman correlation test was performed to determine the association between stiffness, bladder volume, ADC and FA values of both kidneys before and after water intake. The results show a significant increase in stiffness in different regions of the kidney (ie, percentage increase ranged from 3.6% to 7.5%) and bladder volume after water intake (all P < 0.05). A moderate significant negative correlation was observed between change in kidney stiffness and bladder volume (concordance correlation coefficient = ‐0.468, P < 0.05). No significant correlation was observed between stiffness and ADC or FA values before and after water intake in both kidneys (P > 0.05). Water intake caused a significant increase in the stiffness of the kidneys. The negative correlation between the change in kidney stiffness and bladder volume, before and after water intake, indicates higher perfusion pressure in the kidneys, leading to increased stiffness.
Stiffness plays an important role in diagnosing renal fibrosis. However, it is established that perfusion is altered in different kidney diseases, leading to changes in kidney stiffness. This study demonstrated that water intake caused significant increase in the stiffness of the kidneys. Also, negative correlation between changes in kidney stiffness and bladder volume before and after water intake indicates higher perfusion pressure in the kidneys, leading to increased stiffness. |
| doi_str_mv | 10.1002/nbm.4237 |
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Stiffness plays an important role in diagnosing renal fibrosis. However, it is established that perfusion is altered in different kidney diseases, leading to changes in kidney stiffness. This study demonstrated that water intake caused significant increase in the stiffness of the kidneys. Also, negative correlation between changes in kidney stiffness and bladder volume before and after water intake indicates higher perfusion pressure in the kidneys, leading to increased stiffness.</description><identifier>ISSN: 0952-3480</identifier><identifier>EISSN: 1099-1492</identifier><identifier>DOI: 10.1002/nbm.4237</identifier><identifier>PMID: 31889353</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Anisotropy ; Biological products ; Biomechanical Phenomena ; Bladder ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Diffusion coefficient ; Diffusion Tensor Imaging ; Elasticity Imaging Techniques ; Female ; Fibrosis ; Humans ; Kidney - diagnostic imaging ; Kidney - physiology ; kidney diffusion tensor imaging ; Kidney diseases ; kidney magnetic resonance elastography ; kidney perfusion ; kidney stiffness ; Kidneys ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Perfusion ; Resonance ; Spin Labels ; Stiffness ; Tensors ; Water - chemistry ; Water intake ; Water intakes ; Young Adult</subject><ispartof>NMR in biomedicine, 2020-04, Vol.33 (4), p.e4237-n/a</ispartof><rights>2019 John Wiley & Sons, Ltd.</rights><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3837-56fa32bdbc5e91c8febd4455beed659df49f4e580a13669ed7f0215e6c388fcf3</citedby><cites>FETCH-LOGICAL-c3837-56fa32bdbc5e91c8febd4455beed659df49f4e580a13669ed7f0215e6c388fcf3</cites><orcidid>0000-0002-9479-5427 ; 0000-0003-2695-4251</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnbm.4237$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnbm.4237$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31889353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gandhi, Deep</creatorcontrib><creatorcontrib>Kalra, Prateek</creatorcontrib><creatorcontrib>Raterman, Brian</creatorcontrib><creatorcontrib>Mo, Xiaokui</creatorcontrib><creatorcontrib>Dong, Huiming</creatorcontrib><creatorcontrib>Kolipaka, Arunark</creatorcontrib><title>Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion</title><title>NMR in biomedicine</title><addtitle>NMR Biomed</addtitle><description>Stiffness plays an important role in diagnosing renal fibrosis. However, kidney stiffness is altered by perfusion changes in many kidney diseases. Therefore, the aim of the current study is to determine the correlation of kidney stiffness with water intake. We hypothesize that kidney stiffness will increase with 1 L of water intake due to increased water perfusion to the kidneys. Additionally, stiffness of the kidneys will correlate with apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values before and after water intake. A 3 T MRI scanner was used to perform magnetic resonance elastography and diffusion tensor imaging of the kidneys on 24 healthy subjects (age range: 22‐66 years) before and after water intake of 1 L. A 3D T1‐weighted bladder scan was also performed to measure bladder volume before and after water intake. A paired t‐test was performed to evaluate the effect of water intake on the stiffness of kidneys, in addition to bladder volume. A Spearman correlation test was performed to determine the association between stiffness, bladder volume, ADC and FA values of both kidneys before and after water intake. The results show a significant increase in stiffness in different regions of the kidney (ie, percentage increase ranged from 3.6% to 7.5%) and bladder volume after water intake (all P < 0.05). A moderate significant negative correlation was observed between change in kidney stiffness and bladder volume (concordance correlation coefficient = ‐0.468, P < 0.05). No significant correlation was observed between stiffness and ADC or FA values before and after water intake in both kidneys (P > 0.05). Water intake caused a significant increase in the stiffness of the kidneys. The negative correlation between the change in kidney stiffness and bladder volume, before and after water intake, indicates higher perfusion pressure in the kidneys, leading to increased stiffness.
Stiffness plays an important role in diagnosing renal fibrosis. However, it is established that perfusion is altered in different kidney diseases, leading to changes in kidney stiffness. This study demonstrated that water intake caused significant increase in the stiffness of the kidneys. Also, negative correlation between changes in kidney stiffness and bladder volume before and after water intake indicates higher perfusion pressure in the kidneys, leading to increased stiffness.</description><subject>Adult</subject><subject>Aged</subject><subject>Anisotropy</subject><subject>Biological products</subject><subject>Biomechanical Phenomena</subject><subject>Bladder</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Diffusion coefficient</subject><subject>Diffusion Tensor Imaging</subject><subject>Elasticity Imaging Techniques</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiology</subject><subject>kidney diffusion tensor imaging</subject><subject>Kidney diseases</subject><subject>kidney magnetic resonance elastography</subject><subject>kidney perfusion</subject><subject>kidney stiffness</subject><subject>Kidneys</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Perfusion</subject><subject>Resonance</subject><subject>Spin Labels</subject><subject>Stiffness</subject><subject>Tensors</subject><subject>Water - chemistry</subject><subject>Water intake</subject><subject>Water intakes</subject><subject>Young Adult</subject><issn>0952-3480</issn><issn>1099-1492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9qFTEUh4NY7G0VfAIJuHEzbf7OJEstWoVWN7oeMslJb9q5yTXJ9HJ3PoLP6JOY2qoguDpw-H4fh_ND6DklJ5QQdhqnzYlgfHiEVpRo3VGh2WO0IlqyjgtFDtFRKdeEECU4e4IOOVVKc8lX6ObSXEWoweIMJUUTLWCYTanpKpvtev_j23cHOdyCw6UG7yOUgpPHdQ34JrgI-4JNdDjUgm3KuWVrSBHvQl3jnamQ8RayX0pbPkUH3swFnj3MY_Tl3dvPZ--7i0_nH85eX3SWKz50sveGs8lNVoKmVnmYnBBSTgCul9p5ob0AqYihvO81uMETRiX0La689fwYvbr3bnP6ukCp4yYUC_NsIqSljIxz2nMuGW3oy3_Q67Tk2K5r1MCokGxQf4U2p1Iy-HGbw8bk_UjJeFfA2AoY7wpo6IsH4TJtwP0Bf3-8Ad09sAsz7P8rGj--ufwl_Anim5H2</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Gandhi, Deep</creator><creator>Kalra, Prateek</creator><creator>Raterman, Brian</creator><creator>Mo, Xiaokui</creator><creator>Dong, Huiming</creator><creator>Kolipaka, Arunark</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9479-5427</orcidid><orcidid>https://orcid.org/0000-0003-2695-4251</orcidid></search><sort><creationdate>202004</creationdate><title>Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion</title><author>Gandhi, Deep ; Kalra, Prateek ; Raterman, Brian ; Mo, Xiaokui ; Dong, Huiming ; Kolipaka, Arunark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3837-56fa32bdbc5e91c8febd4455beed659df49f4e580a13669ed7f0215e6c388fcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anisotropy</topic><topic>Biological products</topic><topic>Biomechanical Phenomena</topic><topic>Bladder</topic><topic>Correlation analysis</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Diffusion coefficient</topic><topic>Diffusion Tensor Imaging</topic><topic>Elasticity Imaging Techniques</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiology</topic><topic>kidney diffusion tensor imaging</topic><topic>Kidney diseases</topic><topic>kidney magnetic resonance elastography</topic><topic>kidney perfusion</topic><topic>kidney stiffness</topic><topic>Kidneys</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Perfusion</topic><topic>Resonance</topic><topic>Spin Labels</topic><topic>Stiffness</topic><topic>Tensors</topic><topic>Water - chemistry</topic><topic>Water intake</topic><topic>Water intakes</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gandhi, Deep</creatorcontrib><creatorcontrib>Kalra, Prateek</creatorcontrib><creatorcontrib>Raterman, Brian</creatorcontrib><creatorcontrib>Mo, Xiaokui</creatorcontrib><creatorcontrib>Dong, Huiming</creatorcontrib><creatorcontrib>Kolipaka, Arunark</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>NMR in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gandhi, Deep</au><au>Kalra, Prateek</au><au>Raterman, Brian</au><au>Mo, Xiaokui</au><au>Dong, Huiming</au><au>Kolipaka, Arunark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion</atitle><jtitle>NMR in biomedicine</jtitle><addtitle>NMR Biomed</addtitle><date>2020-04</date><risdate>2020</risdate><volume>33</volume><issue>4</issue><spage>e4237</spage><epage>n/a</epage><pages>e4237-n/a</pages><issn>0952-3480</issn><eissn>1099-1492</eissn><abstract>Stiffness plays an important role in diagnosing renal fibrosis. However, kidney stiffness is altered by perfusion changes in many kidney diseases. Therefore, the aim of the current study is to determine the correlation of kidney stiffness with water intake. We hypothesize that kidney stiffness will increase with 1 L of water intake due to increased water perfusion to the kidneys. Additionally, stiffness of the kidneys will correlate with apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values before and after water intake. A 3 T MRI scanner was used to perform magnetic resonance elastography and diffusion tensor imaging of the kidneys on 24 healthy subjects (age range: 22‐66 years) before and after water intake of 1 L. A 3D T1‐weighted bladder scan was also performed to measure bladder volume before and after water intake. A paired t‐test was performed to evaluate the effect of water intake on the stiffness of kidneys, in addition to bladder volume. A Spearman correlation test was performed to determine the association between stiffness, bladder volume, ADC and FA values of both kidneys before and after water intake. The results show a significant increase in stiffness in different regions of the kidney (ie, percentage increase ranged from 3.6% to 7.5%) and bladder volume after water intake (all P < 0.05). A moderate significant negative correlation was observed between change in kidney stiffness and bladder volume (concordance correlation coefficient = ‐0.468, P < 0.05). No significant correlation was observed between stiffness and ADC or FA values before and after water intake in both kidneys (P > 0.05). Water intake caused a significant increase in the stiffness of the kidneys. The negative correlation between the change in kidney stiffness and bladder volume, before and after water intake, indicates higher perfusion pressure in the kidneys, leading to increased stiffness.
Stiffness plays an important role in diagnosing renal fibrosis. However, it is established that perfusion is altered in different kidney diseases, leading to changes in kidney stiffness. This study demonstrated that water intake caused significant increase in the stiffness of the kidneys. Also, negative correlation between changes in kidney stiffness and bladder volume before and after water intake indicates higher perfusion pressure in the kidneys, leading to increased stiffness.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31889353</pmid><doi>10.1002/nbm.4237</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-9479-5427</orcidid><orcidid>https://orcid.org/0000-0003-2695-4251</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anisotropy Biological products Biomechanical Phenomena Bladder Correlation analysis Correlation coefficient Correlation coefficients Diffusion coefficient Diffusion Tensor Imaging Elasticity Imaging Techniques Female Fibrosis Humans Kidney - diagnostic imaging Kidney - physiology kidney diffusion tensor imaging Kidney diseases kidney magnetic resonance elastography kidney perfusion kidney stiffness Kidneys Magnetic Resonance Imaging Male Middle Aged Perfusion Resonance Spin Labels Stiffness Tensors Water - chemistry Water intake Water intakes Young Adult |
| title | Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion |
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