How evolution shapes enzyme selectivity – lessons from aminoacyl‐tRNA synthetases and other amino acid utilizing enzymes

Aminoacyl‐tRNA synthetases (AARSs) charge tRNA with their cognate amino acids. Many other enzymes use amino acids as substrates, yet discrimination against noncognate amino acids that threaten the accuracy of protein translation is a hallmark of AARSs. Comparing AARSs to these other enzymes allowed...

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Veröffentlicht in:	The FEBS journal 2020-04, Vol.287 (7), p.1284-1305
Hauptverfasser:	Tawfik, Dan S., Gruic‐Sovulj, Ita
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid selectivity Amino acids Amino Acids - metabolism Amino Acyl-tRNA Synthetases - metabolism aminoacyl‐tRNA synthetases Discrimination Editing enzyme specificity Enzymes Evolution Evolution, Molecular Hydroxyl groups Negative selection Pattern recognition Selectivity Substrate Specificity Substrates tRNA
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