Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects
Asbestos exposure is associated with a dose-dependent risk of lung cancer. The association between lung cancer and the presence of pleural plaques remains controversial. To define the relationship between pleural plaques and lung cancer risk. Subjects were from two cohorts: ) crocidolite mine and mi...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2020-01, Vol.201 (1), p.57-62 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Brims, Fraser J H Kong, Karen Harris, Ed J A Sodhi-Berry, Nita Reid, Alison Murray, Conor P Franklin, Peter J Musk, A Bill de Klerk, Nicholas H |
| description | Asbestos exposure is associated with a dose-dependent risk of lung cancer. The association between lung cancer and the presence of pleural plaques remains controversial.
To define the relationship between pleural plaques and lung cancer risk.
Subjects were from two cohorts:
) crocidolite mine and mill workers and Wittenoom Township residents and
) a mixed-asbestos-fiber, mixed-occupation group. All subjects underwent annual review since 1990, chest X-ray or low-dose computed tomography scan, and outcome linkage to national cancer and mortality registry data. Cox regression, with adjustment for age (as the underlying matching time variable), was used to estimate hazard ratios (HRs) for lung cancer incidence by sex, tobacco smoking, asbestos exposure, presence of asbestosis, and pleural plaques.
For all 4,240 subjects, mean age at follow up was 65.4 years, 3,486 (82.0%) were male, 1,315 (31.0%) had pleural plaques, and 1,353 (32.0%) had radiographic asbestosis. Overall, 3,042 (71.7%) were ever-smokers with mean tobacco exposure of 33 pack-years. In total, 200 lung cancers were recorded. Risk of lung cancer increased with cumulative exposure to cigarettes, asbestos, and presence of asbestosis. Pleural plaques did not confer any additional lung cancer risk in either cohort (cohort 1: HR, 1.03; 95% confidence interval, 0.64-1.67;
= 0.89; cohort 2: HR, 0.75; 95% confidence interval, 0.45-1.25;
= 0.28).
The presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer. This result is consistent across two cohorts with differing asbestos fiber exposures and intensity. |
| doi_str_mv | 10.1164/rccm.201901-0096OC |
| format | Article |
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To define the relationship between pleural plaques and lung cancer risk.
Subjects were from two cohorts:
) crocidolite mine and mill workers and Wittenoom Township residents and
) a mixed-asbestos-fiber, mixed-occupation group. All subjects underwent annual review since 1990, chest X-ray or low-dose computed tomography scan, and outcome linkage to national cancer and mortality registry data. Cox regression, with adjustment for age (as the underlying matching time variable), was used to estimate hazard ratios (HRs) for lung cancer incidence by sex, tobacco smoking, asbestos exposure, presence of asbestosis, and pleural plaques.
For all 4,240 subjects, mean age at follow up was 65.4 years, 3,486 (82.0%) were male, 1,315 (31.0%) had pleural plaques, and 1,353 (32.0%) had radiographic asbestosis. Overall, 3,042 (71.7%) were ever-smokers with mean tobacco exposure of 33 pack-years. In total, 200 lung cancers were recorded. Risk of lung cancer increased with cumulative exposure to cigarettes, asbestos, and presence of asbestosis. Pleural plaques did not confer any additional lung cancer risk in either cohort (cohort 1: HR, 1.03; 95% confidence interval, 0.64-1.67;
= 0.89; cohort 2: HR, 0.75; 95% confidence interval, 0.45-1.25;
= 0.28).
The presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer. This result is consistent across two cohorts with differing asbestos fiber exposures and intensity.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201901-0096OC</identifier><identifier>PMID: 31433952</identifier><language>eng</language><publisher>United States: American Thoracic Society</publisher><subject>Adult ; Asbestos - adverse effects ; Asbestosis - epidemiology ; Asbestosis - physiopathology ; Cohort Studies ; Female ; Humans ; Incidence ; Lung cancer ; Lung diseases ; Lung Neoplasms - epidemiology ; Lung Neoplasms - physiopathology ; Male ; Middle Aged ; Occupational Exposure - adverse effects ; Pleural Diseases - epidemiology ; Pleural Diseases - physiopathology ; Proportional Hazards Models ; Radiology ; Risk Factors</subject><ispartof>American journal of respiratory and critical care medicine, 2020-01, Vol.201 (1), p.57-62</ispartof><rights>Copyright American Thoracic Society Jan 1, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-6725-7535</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31433952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brims, Fraser J H</creatorcontrib><creatorcontrib>Kong, Karen</creatorcontrib><creatorcontrib>Harris, Ed J A</creatorcontrib><creatorcontrib>Sodhi-Berry, Nita</creatorcontrib><creatorcontrib>Reid, Alison</creatorcontrib><creatorcontrib>Murray, Conor P</creatorcontrib><creatorcontrib>Franklin, Peter J</creatorcontrib><creatorcontrib>Musk, A Bill</creatorcontrib><creatorcontrib>de Klerk, Nicholas H</creatorcontrib><title>Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Asbestos exposure is associated with a dose-dependent risk of lung cancer. The association between lung cancer and the presence of pleural plaques remains controversial.
To define the relationship between pleural plaques and lung cancer risk.
Subjects were from two cohorts:
) crocidolite mine and mill workers and Wittenoom Township residents and
) a mixed-asbestos-fiber, mixed-occupation group. All subjects underwent annual review since 1990, chest X-ray or low-dose computed tomography scan, and outcome linkage to national cancer and mortality registry data. Cox regression, with adjustment for age (as the underlying matching time variable), was used to estimate hazard ratios (HRs) for lung cancer incidence by sex, tobacco smoking, asbestos exposure, presence of asbestosis, and pleural plaques.
For all 4,240 subjects, mean age at follow up was 65.4 years, 3,486 (82.0%) were male, 1,315 (31.0%) had pleural plaques, and 1,353 (32.0%) had radiographic asbestosis. Overall, 3,042 (71.7%) were ever-smokers with mean tobacco exposure of 33 pack-years. In total, 200 lung cancers were recorded. Risk of lung cancer increased with cumulative exposure to cigarettes, asbestos, and presence of asbestosis. Pleural plaques did not confer any additional lung cancer risk in either cohort (cohort 1: HR, 1.03; 95% confidence interval, 0.64-1.67;
= 0.89; cohort 2: HR, 0.75; 95% confidence interval, 0.45-1.25;
= 0.28).
The presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer. This result is consistent across two cohorts with differing asbestos fiber exposures and intensity.</description><subject>Adult</subject><subject>Asbestos - adverse effects</subject><subject>Asbestosis - epidemiology</subject><subject>Asbestosis - physiopathology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occupational Exposure - adverse effects</subject><subject>Pleural Diseases - epidemiology</subject><subject>Pleural Diseases - physiopathology</subject><subject>Proportional Hazards Models</subject><subject>Radiology</subject><subject>Risk Factors</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0MtKw0AUBuBBFFurL-BCBty4SZ17ZpYlVCsUWryAuzCTnGhqbs4koG9vinXj5pyz-Pj5OQhdUjKnVIlbn2X1nBFqCI0IMWqTHKEplVxGwsTkeLxJzCMhzOsEnYWwI4QyTckpmnAqODeSTdFqW8HgbYW3lf0cIGDb5Lh_B_xYhg_cFng9NG84sU0GHpcNXgQHoW9DBF9dGyDHT4PbQdaHc3RS2CrAxWHP0Mvd8jlZRevN_UOyWEcdVaaPGGFWC8mMsgxyBuMsoJCWZxRIETsbx1RbCzJ2ucoKFRvjeEG0c1aDNprP0M1vbufbfeE-rcuQQVXZBtohpIxzqpgQWo70-h_dtYNvxnajkowoTdleXR3U4GrI086XtfXf6d-P-A-zPWjs</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Brims, Fraser J H</creator><creator>Kong, Karen</creator><creator>Harris, Ed J A</creator><creator>Sodhi-Berry, Nita</creator><creator>Reid, Alison</creator><creator>Murray, Conor P</creator><creator>Franklin, Peter J</creator><creator>Musk, A Bill</creator><creator>de Klerk, Nicholas H</creator><general>American Thoracic Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6725-7535</orcidid></search><sort><creationdate>20200101</creationdate><title>Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects</title><author>Brims, Fraser J H ; Kong, Karen ; Harris, Ed J A ; Sodhi-Berry, Nita ; Reid, Alison ; Murray, Conor P ; Franklin, Peter J ; Musk, A Bill ; de Klerk, Nicholas H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p169t-202a845296a2ed2ea2efef5a3c1e0f7ba7718aae57bd6cf6799b3f08bba8e8983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Asbestos - adverse effects</topic><topic>Asbestosis - epidemiology</topic><topic>Asbestosis - physiopathology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occupational Exposure - adverse effects</topic><topic>Pleural Diseases - epidemiology</topic><topic>Pleural Diseases - physiopathology</topic><topic>Proportional Hazards Models</topic><topic>Radiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brims, Fraser J H</creatorcontrib><creatorcontrib>Kong, Karen</creatorcontrib><creatorcontrib>Harris, Ed J A</creatorcontrib><creatorcontrib>Sodhi-Berry, Nita</creatorcontrib><creatorcontrib>Reid, Alison</creatorcontrib><creatorcontrib>Murray, Conor P</creatorcontrib><creatorcontrib>Franklin, Peter J</creatorcontrib><creatorcontrib>Musk, A Bill</creatorcontrib><creatorcontrib>de Klerk, Nicholas H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brims, Fraser J H</au><au>Kong, Karen</au><au>Harris, Ed J A</au><au>Sodhi-Berry, Nita</au><au>Reid, Alison</au><au>Murray, Conor P</au><au>Franklin, Peter J</au><au>Musk, A Bill</au><au>de Klerk, Nicholas H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>201</volume><issue>1</issue><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Asbestos exposure is associated with a dose-dependent risk of lung cancer. The association between lung cancer and the presence of pleural plaques remains controversial.
To define the relationship between pleural plaques and lung cancer risk.
Subjects were from two cohorts:
) crocidolite mine and mill workers and Wittenoom Township residents and
) a mixed-asbestos-fiber, mixed-occupation group. All subjects underwent annual review since 1990, chest X-ray or low-dose computed tomography scan, and outcome linkage to national cancer and mortality registry data. Cox regression, with adjustment for age (as the underlying matching time variable), was used to estimate hazard ratios (HRs) for lung cancer incidence by sex, tobacco smoking, asbestos exposure, presence of asbestosis, and pleural plaques.
For all 4,240 subjects, mean age at follow up was 65.4 years, 3,486 (82.0%) were male, 1,315 (31.0%) had pleural plaques, and 1,353 (32.0%) had radiographic asbestosis. Overall, 3,042 (71.7%) were ever-smokers with mean tobacco exposure of 33 pack-years. In total, 200 lung cancers were recorded. Risk of lung cancer increased with cumulative exposure to cigarettes, asbestos, and presence of asbestosis. Pleural plaques did not confer any additional lung cancer risk in either cohort (cohort 1: HR, 1.03; 95% confidence interval, 0.64-1.67;
= 0.89; cohort 2: HR, 0.75; 95% confidence interval, 0.45-1.25;
= 0.28).
The presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer. This result is consistent across two cohorts with differing asbestos fiber exposures and intensity.</abstract><cop>United States</cop><pub>American Thoracic Society</pub><pmid>31433952</pmid><doi>10.1164/rccm.201901-0096OC</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6725-7535</orcidid></addata></record> |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Asbestos - adverse effects Asbestosis - epidemiology Asbestosis - physiopathology Cohort Studies Female Humans Incidence Lung cancer Lung diseases Lung Neoplasms - epidemiology Lung Neoplasms - physiopathology Male Middle Aged Occupational Exposure - adverse effects Pleural Diseases - epidemiology Pleural Diseases - physiopathology Proportional Hazards Models Radiology Risk Factors |
| title | Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects |
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