Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection
•A texture-based biomarker was developed that detected changes in atherosclerotic plaque due to dietary intervention with high sensitivity.•Established the effect of pomegranate juice and tablets in a statistically significant manner for the first time.•The proposed biomarker requires 20 times fewer...
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| Veröffentlicht in: | Computer methods and programs in biomedicine 2020-02, Vol.184, p.105276-105276, Article 105276 |
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| creator | Chen, Xueli Lin, Mingquan Cui, He Chen, Yimin van Engelen, Arna de Bruijne, Marleen Azarpazhooh, M. Reza Sohrevardi, Seyed Mojtaba Chow, Tommy W.S. Spence, J. David Chiu, Bernard |
| description | •A texture-based biomarker was developed that detected changes in atherosclerotic plaque due to dietary intervention with high sensitivity.•Established the effect of pomegranate juice and tablets in a statistically significant manner for the first time.•The proposed biomarker requires 20 times fewer subjects than total plaque volume (TPV) to detect the effect of pomegranate.
Background and objective: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.
Methods: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.
Results: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10−5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.
Conclusion: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed. |
| doi_str_mv | 10.1016/j.cmpb.2019.105276 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2331623643</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169260719302147</els_id><sourcerecordid>2331623643</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-de8bad3a44cad68fea055aa06ce416c18122270cbceeab381f196364ab02f82e3</originalsourceid><addsrcrecordid>eNp9kc9O3DAQxq2KqmyBF-ih8pFLFv_ZOFmplwoBRULqhZ6tiT0Br5w4tZ1V9x360Dha4MjJ8szv-8aej5BvnK054-pqtzbD1K0F49tSqEWjPpEVbxtRNbWqT8iqQNtKKNackq8p7Rhjoq7VF3Iqeds2ijcr8v_xOSJW1g04JhdG8HT2OUIK82gp7sHPkEudhp7mZ6TY92hyWq5TGPApwggZl1aE6UALaCCG7CydPPydSwf_5TkinZMbn6gPBrzLBzpFTBj3S22KYVc8y5Bz8rkHn_Di9Twjf25vHq9_VQ-_7-6vfz5URtYqVxbbDqyEzcaAVW2PwOoagCmDG64Mb7kQomGmM4jQyZb3fKuk2kDHRN8KlGfk8uhbRpc3pqwHlwx6DyOGOWkhJVeiKGRBxRE1MaQUsddTdAPEg-ZMLynonV5S0EsK-phCEX1_9Z-7Ae275G3tBfhxBLD8cu8w6mQcjgati2UV2gb3kf8LEwSdgg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2331623643</pqid></control><display><type>article</type><title>Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Chen, Xueli ; Lin, Mingquan ; Cui, He ; Chen, Yimin ; van Engelen, Arna ; de Bruijne, Marleen ; Azarpazhooh, M. Reza ; Sohrevardi, Seyed Mojtaba ; Chow, Tommy W.S. ; Spence, J. David ; Chiu, Bernard</creator><creatorcontrib>Chen, Xueli ; Lin, Mingquan ; Cui, He ; Chen, Yimin ; van Engelen, Arna ; de Bruijne, Marleen ; Azarpazhooh, M. Reza ; Sohrevardi, Seyed Mojtaba ; Chow, Tommy W.S. ; Spence, J. David ; Chiu, Bernard</creatorcontrib><description>•A texture-based biomarker was developed that detected changes in atherosclerotic plaque due to dietary intervention with high sensitivity.•Established the effect of pomegranate juice and tablets in a statistically significant manner for the first time.•The proposed biomarker requires 20 times fewer subjects than total plaque volume (TPV) to detect the effect of pomegranate.
Background and objective: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.
Methods: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.
Results: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10−5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.
Conclusion: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed.</description><identifier>ISSN: 0169-2607</identifier><identifier>EISSN: 1872-7565</identifier><identifier>DOI: 10.1016/j.cmpb.2019.105276</identifier><identifier>PMID: 31887617</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>3D ultrasound imaging ; Aged ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - therapy ; Carotid atherosclerosis ; Female ; Humans ; Male ; Middle Aged ; Neural Networks, Computer ; Phytotherapy ; Plaque texture ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - therapy ; Pomegranate ; Pomegranate therapy ; Ultrasonography - methods</subject><ispartof>Computer methods and programs in biomedicine, 2020-02, Vol.184, p.105276-105276, Article 105276</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-de8bad3a44cad68fea055aa06ce416c18122270cbceeab381f196364ab02f82e3</citedby><cites>FETCH-LOGICAL-c356t-de8bad3a44cad68fea055aa06ce416c18122270cbceeab381f196364ab02f82e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169260719302147$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31887617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xueli</creatorcontrib><creatorcontrib>Lin, Mingquan</creatorcontrib><creatorcontrib>Cui, He</creatorcontrib><creatorcontrib>Chen, Yimin</creatorcontrib><creatorcontrib>van Engelen, Arna</creatorcontrib><creatorcontrib>de Bruijne, Marleen</creatorcontrib><creatorcontrib>Azarpazhooh, M. Reza</creatorcontrib><creatorcontrib>Sohrevardi, Seyed Mojtaba</creatorcontrib><creatorcontrib>Chow, Tommy W.S.</creatorcontrib><creatorcontrib>Spence, J. David</creatorcontrib><creatorcontrib>Chiu, Bernard</creatorcontrib><title>Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection</title><title>Computer methods and programs in biomedicine</title><addtitle>Comput Methods Programs Biomed</addtitle><description>•A texture-based biomarker was developed that detected changes in atherosclerotic plaque due to dietary intervention with high sensitivity.•Established the effect of pomegranate juice and tablets in a statistically significant manner for the first time.•The proposed biomarker requires 20 times fewer subjects than total plaque volume (TPV) to detect the effect of pomegranate.
Background and objective: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.
Methods: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.
Results: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10−5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.
Conclusion: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed.</description><subject>3D ultrasound imaging</subject><subject>Aged</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - therapy</subject><subject>Carotid atherosclerosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neural Networks, Computer</subject><subject>Phytotherapy</subject><subject>Plaque texture</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - therapy</subject><subject>Pomegranate</subject><subject>Pomegranate therapy</subject><subject>Ultrasonography - methods</subject><issn>0169-2607</issn><issn>1872-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9O3DAQxq2KqmyBF-ih8pFLFv_ZOFmplwoBRULqhZ6tiT0Br5w4tZ1V9x360Dha4MjJ8szv-8aej5BvnK054-pqtzbD1K0F49tSqEWjPpEVbxtRNbWqT8iqQNtKKNackq8p7Rhjoq7VF3Iqeds2ijcr8v_xOSJW1g04JhdG8HT2OUIK82gp7sHPkEudhp7mZ6TY92hyWq5TGPApwggZl1aE6UALaCCG7CydPPydSwf_5TkinZMbn6gPBrzLBzpFTBj3S22KYVc8y5Bz8rkHn_Di9Twjf25vHq9_VQ-_7-6vfz5URtYqVxbbDqyEzcaAVW2PwOoagCmDG64Mb7kQomGmM4jQyZb3fKuk2kDHRN8KlGfk8uhbRpc3pqwHlwx6DyOGOWkhJVeiKGRBxRE1MaQUsddTdAPEg-ZMLynonV5S0EsK-phCEX1_9Z-7Ae275G3tBfhxBLD8cu8w6mQcjgati2UV2gb3kf8LEwSdgg</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Chen, Xueli</creator><creator>Lin, Mingquan</creator><creator>Cui, He</creator><creator>Chen, Yimin</creator><creator>van Engelen, Arna</creator><creator>de Bruijne, Marleen</creator><creator>Azarpazhooh, M. Reza</creator><creator>Sohrevardi, Seyed Mojtaba</creator><creator>Chow, Tommy W.S.</creator><creator>Spence, J. David</creator><creator>Chiu, Bernard</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection</title><author>Chen, Xueli ; Lin, Mingquan ; Cui, He ; Chen, Yimin ; van Engelen, Arna ; de Bruijne, Marleen ; Azarpazhooh, M. Reza ; Sohrevardi, Seyed Mojtaba ; Chow, Tommy W.S. ; Spence, J. David ; Chiu, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-de8bad3a44cad68fea055aa06ce416c18122270cbceeab381f196364ab02f82e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>3D ultrasound imaging</topic><topic>Aged</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - therapy</topic><topic>Carotid atherosclerosis</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neural Networks, Computer</topic><topic>Phytotherapy</topic><topic>Plaque texture</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - therapy</topic><topic>Pomegranate</topic><topic>Pomegranate therapy</topic><topic>Ultrasonography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xueli</creatorcontrib><creatorcontrib>Lin, Mingquan</creatorcontrib><creatorcontrib>Cui, He</creatorcontrib><creatorcontrib>Chen, Yimin</creatorcontrib><creatorcontrib>van Engelen, Arna</creatorcontrib><creatorcontrib>de Bruijne, Marleen</creatorcontrib><creatorcontrib>Azarpazhooh, M. Reza</creatorcontrib><creatorcontrib>Sohrevardi, Seyed Mojtaba</creatorcontrib><creatorcontrib>Chow, Tommy W.S.</creatorcontrib><creatorcontrib>Spence, J. David</creatorcontrib><creatorcontrib>Chiu, Bernard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Computer methods and programs in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xueli</au><au>Lin, Mingquan</au><au>Cui, He</au><au>Chen, Yimin</au><au>van Engelen, Arna</au><au>de Bruijne, Marleen</au><au>Azarpazhooh, M. Reza</au><au>Sohrevardi, Seyed Mojtaba</au><au>Chow, Tommy W.S.</au><au>Spence, J. David</au><au>Chiu, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection</atitle><jtitle>Computer methods and programs in biomedicine</jtitle><addtitle>Comput Methods Programs Biomed</addtitle><date>2020-02</date><risdate>2020</risdate><volume>184</volume><spage>105276</spage><epage>105276</epage><pages>105276-105276</pages><artnum>105276</artnum><issn>0169-2607</issn><eissn>1872-7565</eissn><abstract>•A texture-based biomarker was developed that detected changes in atherosclerotic plaque due to dietary intervention with high sensitivity.•Established the effect of pomegranate juice and tablets in a statistically significant manner for the first time.•The proposed biomarker requires 20 times fewer subjects than total plaque volume (TPV) to detect the effect of pomegranate.
Background and objective: Dietary supplements are expected to confer a smaller beneficial effect than medical treatments. Therefore, there is a need to develop cost-effective biomarkers that can demonstrate the efficacy of such supplements for carotid atherosclerosis. The aim of this study is to develop such a biomarker based on the changes of 376 plaque textural features measured from 3D ultrasound images.
Methods: Since the number of features (376) was greater than the number of subjects (171) in this study, principal component analysis (PCA) was applied to reduce the dimensionality of feature vectors. To generate a scalar biomarker for each subject, elements in the reduced feature vectors produced by PCA were weighted using locality preserving projections (LPP) to capture essential patterns exhibited locally in the feature space. 96 subjects treated by pomegranate juice and tablets, and 75 subjects receiving placebo-matching juice and tablets were evaluated in this study. The discriminative power of the proposed biomarker was evaluated and compared with existing biomarkers using t-tests. As the cost of a clinical trial is directly related to the number of subjects enrolled, the cost-effectiveness of the proposed biomarker was evaluated by sample size estimation.
Results: The proposed biomarker was more able to discriminate plaque changes exhibited by the pomegranate and placebo groups than total plaque volume (TPV) according to the result of t-tests (TPV: p=0.34, Proposed biomarker: p=1.5×10−5). The sample size required by the new biomarker to detect a significant effect was 20 times smaller than that required by TPV.
Conclusion: With the increase in cost-effectiveness afforded by the proposed biomarker, more proof-of-principle studies for novel treatment options could be performed.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31887617</pmid><doi>10.1016/j.cmpb.2019.105276</doi><tpages>1</tpages></addata></record> |
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| ispartof | Computer methods and programs in biomedicine, 2020-02, Vol.184, p.105276-105276, Article 105276 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 3D ultrasound imaging Aged Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - therapy Carotid atherosclerosis Female Humans Male Middle Aged Neural Networks, Computer Phytotherapy Plaque texture Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - therapy Pomegranate Pomegranate therapy Ultrasonography - methods |
| title | Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection |
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