Short-term transcriptional response to IL-17 receptor-A antagonism in the treatment of psoriasis

IL-17 antagonists induce impressive clinical benefits in psoriasis, but it is unknown to what extent cellular and molecular psoriasis characteristics are suppressed by a clinically relevant dose/schedule of any IL-17-receptor antagonist. We sought to examine the effects of the IL-17 receptor-A antag...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of allergy and clinical immunology 2020-03, Vol.145 (3), p.922-932
Hauptverfasser:	Tomalin, Lewis E., Russell, Chris B., Garcet, Sandra, Ewald, David Adrian, Klekotka, Paul, Nirula, Ajay, Norsgaard, Hanne, Suàrez-Fariñas, Mayte, Krueger, James G.
Format:	Artikel
Sprache:	eng
Schlagworte:	brodalumab IL-12 IL-17 IL-23 inflammatory cytokines keratinocytes psoriasis transcriptomic profiling ustekinumab
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!