Phosphoproteomic analysis reveals Akt isoform-specific regulation of cytoskeleton proteins in human temporal lobe epilepsy with hippocampal sclerosis

Akt is one of the most important downstream effectors of phosphatidylinositol 3-kinase/mTOR pathway. Hyperactivation and expression of this pathway are seen in a variety of neurological disorders including human temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Nevertheless, the expression...

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Veröffentlicht in:	Neurochemistry international 2020-03, Vol.134, p.104654-104654, Article 104654
Hauptverfasser:	Valmiki, Rajesh Ramanna, Venkatesalu, Subhashini, Chacko, Ari George, Prabhu, Krishna, Thomas, Maya Mary, Mathew, Vivek, Yoganathan, Sangeetha, Muthusamy, Karthik, Chacko, Geeta, Vanjare, Harshad Arvind, Krothapalli, Srinivasa Babu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclic AMP-Dependent Protein Kinases - metabolism Cytoskeletal Proteins - metabolism Cytoskeleton - metabolism Epilepsy, Temporal Lobe - metabolism Hippocampus - metabolism Humans Isoenzymes - metabolism Phosphorylation Sclerosis - metabolism Sclerosis - pathology TOR Serine-Threonine Kinases - metabolism
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