Practical Synthesis of Benzimidazo[1,2‑a]quinolines via Rh(III)-Catalyzed C–H Activation Cascade Reaction from Imidamides and Anthranils
We report a novel and practical one-pot Rh(III)-catalyzed strategy to construct benzimidazo[1,2-a]quinolines from readily available imidamides and anthranils. The cascade reaction proceeds via a C–H amination–cyclization–cyclization process in ionic liquid without any additives and possesses simp...
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| Veröffentlicht in: | Organic letters 2020-01, Vol.22 (2), p.501-504 |
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| container_issue | 2 |
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| container_title | Organic letters |
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| creator | Hu, Yao Wang, Ting Liu, Yanzhao Nie, Ruifang Yang, Ninghong Wang, Qiantao Li, Guo-Bo Wu, Yong |
| description | We report a novel and practical one-pot Rh(III)-catalyzed strategy to construct benzimidazo[1,2-a]quinolines from readily available imidamides and anthranils. The cascade reaction proceeds via a C–H amination–cyclization–cyclization process in ionic liquid without any additives and possesses simple operation, moderate-to-high yield, and broad substrate scope features, which will provide the reference for the construction of biologically active fused benzimidazoles. |
| doi_str_mv | 10.1021/acs.orglett.9b04256 |
| format | Article |
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| source | ACS Publications |
| title | Practical Synthesis of Benzimidazo[1,2‑a]quinolines via Rh(III)-Catalyzed C–H Activation Cascade Reaction from Imidamides and Anthranils |
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