The Effects of Heme Oxygenase Upregulation on Obesity and the Metabolic Syndrome
Obesity is a chronic condition that is characterized by inflammation and oxidative stress with consequent cardiovascular complications of hypertension, dyslipidemia, and vascular dysfunction. Obesity-induced metabolic syndrome remains an epidemic of global proportions. Gene targeting of the endothel...
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| Veröffentlicht in: | Antioxidants & redox signaling 2020-05, Vol.32 (14), p.1061-1070 |
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| container_title | Antioxidants & redox signaling |
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| creator | Peterson, Stephen J Dave, Niel Kothari, Janish |
| description | Obesity is a chronic condition that is characterized by inflammation and oxidative stress with consequent cardiovascular complications of hypertension, dyslipidemia, and vascular dysfunction. Obesity-induced metabolic syndrome remains an epidemic of global proportions.
Gene targeting of the endothelium with a retrovirus using an endothelium-specific promoter vascular endothelium cadherin (VECAD)-HO-1 offers a potential long-term solution to adiposity by targeting the endothelium. This has resulted in improvements of both vascular function and adiposity attenuation.
Heme oxygenase plays an ever-increasing role in the understanding of human biology in the complex conditions of obesity and the metabolic syndrome. The heme oxygenase 1 (HO-1) system creates biliverdin/bilirubin, which functions as an antioxidant, and carbon monoxide, which has antiapoptotic properties.
Upregulation of HO-1 has been shown to improve adiposity as well as vascular function in both animal and human studies. |
| doi_str_mv | 10.1089/ars.2019.7954 |
| format | Article |
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Gene targeting of the endothelium with a retrovirus using an endothelium-specific promoter vascular endothelium cadherin (VECAD)-HO-1 offers a potential long-term solution to adiposity by targeting the endothelium. This has resulted in improvements of both vascular function and adiposity attenuation.
Heme oxygenase plays an ever-increasing role in the understanding of human biology in the complex conditions of obesity and the metabolic syndrome. The heme oxygenase 1 (HO-1) system creates biliverdin/bilirubin, which functions as an antioxidant, and carbon monoxide, which has antiapoptotic properties.
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Gene targeting of the endothelium with a retrovirus using an endothelium-specific promoter vascular endothelium cadherin (VECAD)-HO-1 offers a potential long-term solution to adiposity by targeting the endothelium. This has resulted in improvements of both vascular function and adiposity attenuation.
Heme oxygenase plays an ever-increasing role in the understanding of human biology in the complex conditions of obesity and the metabolic syndrome. The heme oxygenase 1 (HO-1) system creates biliverdin/bilirubin, which functions as an antioxidant, and carbon monoxide, which has antiapoptotic properties.
Upregulation of HO-1 has been shown to improve adiposity as well as vascular function in both animal and human studies.</description><subject>Adipose tissue</subject><subject>Antioxidants</subject><subject>Attenuation</subject><subject>Bilirubin</subject><subject>Biliverdin</subject><subject>Cadherins</subject><subject>Carbon monoxide</subject><subject>Chronic illnesses</subject><subject>Complications</subject><subject>Dyslipidemia</subject><subject>Endothelium</subject><subject>Epidemics</subject><subject>Gene targeting</subject><subject>Heme</subject><subject>Hypertension</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Obesity</subject><subject>Oxidative stress</subject><subject>Oxygenase</subject><subject>Up-regulation</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkE1Lw0AQhhdRbK0evcqCFy-p-5Htbo5SqhUqFWzPYbOZrSn5qLsJmH_vhlYPwsDM4XlfhgehW0qmlKjkUTs_ZYQmU5mI-AyNqRAykpLOzoeb8YioWTxCV97vCSGMUnKJRpwqRRLBxuh98wl4YS2Y1uPG4iVUgNff_Q5q7QFvDw52XanboqlxmHUGvmh7rOsctyH5Bq3OmrIw-KOvc9dUcI0urC493Jz2BG2fF5v5MlqtX17nT6vIcEbbKMsMSGUol0ay2MaJgZxyC1qpHIRNiFCMcyk0p7kyxEgtMiIsN7NEKhtTPkEPx96Da7468G1aFd5AWeoams6nIU1ZcEEG9P4fum86V4fvAqUEEzMak0BFR8q4xnsHNj24otKuTylJB9VpUJ0OqtNBdeDvTq1dVkH-R_-65T-sVHid</recordid><startdate>20200510</startdate><enddate>20200510</enddate><creator>Peterson, Stephen J</creator><creator>Dave, Niel</creator><creator>Kothari, Janish</creator><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20200510</creationdate><title>The Effects of Heme Oxygenase Upregulation on Obesity and the Metabolic Syndrome</title><author>Peterson, Stephen J ; Dave, Niel ; Kothari, Janish</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-bbce78c137c724f49ced13fea88de5f905823375a31d8c0c7a5b05f3c6978f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>Antioxidants</topic><topic>Attenuation</topic><topic>Bilirubin</topic><topic>Biliverdin</topic><topic>Cadherins</topic><topic>Carbon monoxide</topic><topic>Chronic illnesses</topic><topic>Complications</topic><topic>Dyslipidemia</topic><topic>Endothelium</topic><topic>Epidemics</topic><topic>Gene targeting</topic><topic>Heme</topic><topic>Hypertension</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Obesity</topic><topic>Oxidative stress</topic><topic>Oxygenase</topic><topic>Up-regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peterson, Stephen J</creatorcontrib><creatorcontrib>Dave, Niel</creatorcontrib><creatorcontrib>Kothari, Janish</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peterson, Stephen J</au><au>Dave, Niel</au><au>Kothari, Janish</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Heme Oxygenase Upregulation on Obesity and the Metabolic Syndrome</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2020-05-10</date><risdate>2020</risdate><volume>32</volume><issue>14</issue><spage>1061</spage><epage>1070</epage><pages>1061-1070</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>Obesity is a chronic condition that is characterized by inflammation and oxidative stress with consequent cardiovascular complications of hypertension, dyslipidemia, and vascular dysfunction. Obesity-induced metabolic syndrome remains an epidemic of global proportions.
Gene targeting of the endothelium with a retrovirus using an endothelium-specific promoter vascular endothelium cadherin (VECAD)-HO-1 offers a potential long-term solution to adiposity by targeting the endothelium. This has resulted in improvements of both vascular function and adiposity attenuation.
Heme oxygenase plays an ever-increasing role in the understanding of human biology in the complex conditions of obesity and the metabolic syndrome. The heme oxygenase 1 (HO-1) system creates biliverdin/bilirubin, which functions as an antioxidant, and carbon monoxide, which has antiapoptotic properties.
Upregulation of HO-1 has been shown to improve adiposity as well as vascular function in both animal and human studies.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>31880952</pmid><doi>10.1089/ars.2019.7954</doi><tpages>10</tpages></addata></record> |
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| ispartof | Antioxidants & redox signaling, 2020-05, Vol.32 (14), p.1061-1070 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Adipose tissue Antioxidants Attenuation Bilirubin Biliverdin Cadherins Carbon monoxide Chronic illnesses Complications Dyslipidemia Endothelium Epidemics Gene targeting Heme Hypertension Metabolic disorders Metabolic syndrome Obesity Oxidative stress Oxygenase Up-regulation |
| title | The Effects of Heme Oxygenase Upregulation on Obesity and the Metabolic Syndrome |
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