Preclinical safety profile of disitamab vedotin:a novel anti-HER2 antibody conjugated with MMAE

•The toxicities associated with Disitamab vedotin were well characterized. Disitamab vedotin was well tolerated in preclinical studies in cynomolgus monkeys, the highest non-severely toxic dose was 6 mg/kg in repeated dose toxicity studies.•Disitamab vedotin toxicities are hematology toxicity that r...

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Veröffentlicht in:Toxicology letters 2020-05, Vol.324, p.30-37
Hauptverfasser: Jiang, Jing, Li, Shenjun, Shan, Xiaolei, Wang, Ling, Ma, Jinling, Huang, Min, Dong, Lihou, Chen, Fang
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Sprache:eng
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