Micro-CT based finite element modelling and experimental characterization of the compressive mechanical properties of 3-D zirconia scaffolds for bone tissue engineering
The present study aims at developing a computational framework with experimental validation to determine the mechanical properties of zirconia foams for bone tissue engineering. A micro-CT based finite element model that allows characterizing the mechanical property of such cellular structures is de...
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Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2020-02, Vol.102, p.103516-103516, Article 103516 |
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creator | Askari, E. Cengiz, I.F. Alves, J.L. Henriques, B. Flores, P. Fredel, M.C. Reis, R.L. Oliveira, J.M. Silva, F.S. Mesquita-Guimarães, J. |
description | The present study aims at developing a computational framework with experimental validation to determine the mechanical properties of zirconia foams for bone tissue engineering. A micro-CT based finite element model that allows characterizing the mechanical property of such cellular structures is developed. Micro-CT images are filtered to vanish noises and smooth boundaries before constructing 3D zirconia foams using an adaptive Body-Centered Cubic background lattice. In addition to micro-CT images, the local material property at the scaffold struts is measured using a micro-indentation test, which shows a considerable difference with that of common zirconia owing to the manufacturing process. The computational model also takes the plastic deformation of material into account employing the Voce law, a nonlinear isotropic hardening law, as well as Von-mises yield criterion. Zirconia foams with different pore sizes are manufactured using the replica method and their mechanical properties determined experimentally. Such experimental outcomes are to validate and demonstrate the capability of the developed model, which can be used for pre-operational evaluations and preclinical tests of zirconia scaffolds. The stress magnitude and distribution within the scaffold as well as plastic strains and flow stress of the zirconia scaffold are computed and analysed. Using the proposed approach, a deep insight into the association of macroscopic behaviour of the scaffold to microscopic features, e.g. strut waviness, Plateau border, thickness variation of cells, irregularity, microstructural variability, imperfections and strut's material property associated with to the manufacturing procedure, can be gained. |
doi_str_mv | 10.1016/j.jmbbm.2019.103516 |
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A micro-CT based finite element model that allows characterizing the mechanical property of such cellular structures is developed. Micro-CT images are filtered to vanish noises and smooth boundaries before constructing 3D zirconia foams using an adaptive Body-Centered Cubic background lattice. In addition to micro-CT images, the local material property at the scaffold struts is measured using a micro-indentation test, which shows a considerable difference with that of common zirconia owing to the manufacturing process. The computational model also takes the plastic deformation of material into account employing the Voce law, a nonlinear isotropic hardening law, as well as Von-mises yield criterion. Zirconia foams with different pore sizes are manufactured using the replica method and their mechanical properties determined experimentally. Such experimental outcomes are to validate and demonstrate the capability of the developed model, which can be used for pre-operational evaluations and preclinical tests of zirconia scaffolds. The stress magnitude and distribution within the scaffold as well as plastic strains and flow stress of the zirconia scaffold are computed and analysed. Using the proposed approach, a deep insight into the association of macroscopic behaviour of the scaffold to microscopic features, e.g. strut waviness, Plateau border, thickness variation of cells, irregularity, microstructural variability, imperfections and strut's material property associated with to the manufacturing procedure, can be gained.</description><identifier>ISSN: 1751-6161</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2019.103516</identifier><identifier>PMID: 31877521</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Bone and Bones ; Finite Element Analysis ; Mechanical properties ; Micro-CT based FE modelling ; Stress, Mechanical ; Tissue Engineering ; Tissue Scaffolds ; Trabecular bone ; X-Ray Microtomography ; Zirconia scaffolds ; Zirconium</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2020-02, Vol.102, p.103516-103516, Article 103516</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-6d8cdde2bfeb9dd40856e23438203a8fa77f428427b96dbd9c8470edb3c215f23</citedby><cites>FETCH-LOGICAL-c359t-6d8cdde2bfeb9dd40856e23438203a8fa77f428427b96dbd9c8470edb3c215f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmbbm.2019.103516$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31877521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Askari, E.</creatorcontrib><creatorcontrib>Cengiz, I.F.</creatorcontrib><creatorcontrib>Alves, J.L.</creatorcontrib><creatorcontrib>Henriques, B.</creatorcontrib><creatorcontrib>Flores, P.</creatorcontrib><creatorcontrib>Fredel, M.C.</creatorcontrib><creatorcontrib>Reis, R.L.</creatorcontrib><creatorcontrib>Oliveira, J.M.</creatorcontrib><creatorcontrib>Silva, F.S.</creatorcontrib><creatorcontrib>Mesquita-Guimarães, J.</creatorcontrib><title>Micro-CT based finite element modelling and experimental characterization of the compressive mechanical properties of 3-D zirconia scaffolds for bone tissue engineering</title><title>Journal of the mechanical behavior of biomedical materials</title><addtitle>J Mech Behav Biomed Mater</addtitle><description>The present study aims at developing a computational framework with experimental validation to determine the mechanical properties of zirconia foams for bone tissue engineering. A micro-CT based finite element model that allows characterizing the mechanical property of such cellular structures is developed. Micro-CT images are filtered to vanish noises and smooth boundaries before constructing 3D zirconia foams using an adaptive Body-Centered Cubic background lattice. In addition to micro-CT images, the local material property at the scaffold struts is measured using a micro-indentation test, which shows a considerable difference with that of common zirconia owing to the manufacturing process. The computational model also takes the plastic deformation of material into account employing the Voce law, a nonlinear isotropic hardening law, as well as Von-mises yield criterion. Zirconia foams with different pore sizes are manufactured using the replica method and their mechanical properties determined experimentally. Such experimental outcomes are to validate and demonstrate the capability of the developed model, which can be used for pre-operational evaluations and preclinical tests of zirconia scaffolds. The stress magnitude and distribution within the scaffold as well as plastic strains and flow stress of the zirconia scaffold are computed and analysed. Using the proposed approach, a deep insight into the association of macroscopic behaviour of the scaffold to microscopic features, e.g. strut waviness, Plateau border, thickness variation of cells, irregularity, microstructural variability, imperfections and strut's material property associated with to the manufacturing procedure, can be gained.</description><subject>Bone and Bones</subject><subject>Finite Element Analysis</subject><subject>Mechanical properties</subject><subject>Micro-CT based FE modelling</subject><subject>Stress, Mechanical</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><subject>Trabecular bone</subject><subject>X-Ray Microtomography</subject><subject>Zirconia scaffolds</subject><subject>Zirconium</subject><issn>1751-6161</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcluFDEQhluIiCzwBEjIRy49eOnFfeCAJmxSUC7hbHkpT2rUbQ-2Jwp5ojwmHiZwzMlW1Vf-y__fNG8ZXTHKhg_b1XYxZllxyqZaET0bXjRnTI6ypUzSl_U-9qwd2MBOm_Oct5QOlEr5qjkVlRp7zs6axx9oU2zXN8ToDI54DFiAwAwLhEKW6GCeMWyIDo7A_Q4SHhp6JvZWJ21LLTzogjGQ6Em5BWLjskuQM94BWaBSAW3FdynW4YKQD6BoL8kDJhsDapKt9j7OLhMfEzExACmY876uETYYoEqEzevmxOs5w5un86L5-eXzzfpbe3X99fv601VrRT-VdnDSOgfceDCTcx2V_QBcdEJyKrT0ehx9x2XHRzMNzrjJym6k4IywnPWei4vm_fHduvCvPeSiFsy2mqADxH1WXAjGe9qNoqLiiFYHc07g1a66o9Nvxag6RKS26m9E6hCROkZUp949CezNAu7_zL9MKvDxCED95h1CUtkiBAsOE9iiXMRnBf4A87unUw</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Askari, E.</creator><creator>Cengiz, I.F.</creator><creator>Alves, J.L.</creator><creator>Henriques, B.</creator><creator>Flores, P.</creator><creator>Fredel, M.C.</creator><creator>Reis, R.L.</creator><creator>Oliveira, J.M.</creator><creator>Silva, F.S.</creator><creator>Mesquita-Guimarães, J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>Micro-CT based finite element modelling and experimental characterization of the compressive mechanical properties of 3-D zirconia scaffolds for bone tissue engineering</title><author>Askari, E. ; Cengiz, I.F. ; Alves, J.L. ; Henriques, B. ; Flores, P. ; Fredel, M.C. ; Reis, R.L. ; Oliveira, J.M. ; Silva, F.S. ; Mesquita-Guimarães, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-6d8cdde2bfeb9dd40856e23438203a8fa77f428427b96dbd9c8470edb3c215f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bone and Bones</topic><topic>Finite Element Analysis</topic><topic>Mechanical properties</topic><topic>Micro-CT based FE modelling</topic><topic>Stress, Mechanical</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds</topic><topic>Trabecular bone</topic><topic>X-Ray Microtomography</topic><topic>Zirconia scaffolds</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Askari, E.</creatorcontrib><creatorcontrib>Cengiz, I.F.</creatorcontrib><creatorcontrib>Alves, J.L.</creatorcontrib><creatorcontrib>Henriques, B.</creatorcontrib><creatorcontrib>Flores, P.</creatorcontrib><creatorcontrib>Fredel, M.C.</creatorcontrib><creatorcontrib>Reis, R.L.</creatorcontrib><creatorcontrib>Oliveira, J.M.</creatorcontrib><creatorcontrib>Silva, F.S.</creatorcontrib><creatorcontrib>Mesquita-Guimarães, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Askari, E.</au><au>Cengiz, I.F.</au><au>Alves, J.L.</au><au>Henriques, B.</au><au>Flores, P.</au><au>Fredel, M.C.</au><au>Reis, R.L.</au><au>Oliveira, J.M.</au><au>Silva, F.S.</au><au>Mesquita-Guimarães, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micro-CT based finite element modelling and experimental characterization of the compressive mechanical properties of 3-D zirconia scaffolds for bone tissue engineering</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><addtitle>J Mech Behav Biomed Mater</addtitle><date>2020-02</date><risdate>2020</risdate><volume>102</volume><spage>103516</spage><epage>103516</epage><pages>103516-103516</pages><artnum>103516</artnum><issn>1751-6161</issn><eissn>1878-0180</eissn><abstract>The present study aims at developing a computational framework with experimental validation to determine the mechanical properties of zirconia foams for bone tissue engineering. A micro-CT based finite element model that allows characterizing the mechanical property of such cellular structures is developed. Micro-CT images are filtered to vanish noises and smooth boundaries before constructing 3D zirconia foams using an adaptive Body-Centered Cubic background lattice. In addition to micro-CT images, the local material property at the scaffold struts is measured using a micro-indentation test, which shows a considerable difference with that of common zirconia owing to the manufacturing process. The computational model also takes the plastic deformation of material into account employing the Voce law, a nonlinear isotropic hardening law, as well as Von-mises yield criterion. Zirconia foams with different pore sizes are manufactured using the replica method and their mechanical properties determined experimentally. Such experimental outcomes are to validate and demonstrate the capability of the developed model, which can be used for pre-operational evaluations and preclinical tests of zirconia scaffolds. The stress magnitude and distribution within the scaffold as well as plastic strains and flow stress of the zirconia scaffold are computed and analysed. Using the proposed approach, a deep insight into the association of macroscopic behaviour of the scaffold to microscopic features, e.g. strut waviness, Plateau border, thickness variation of cells, irregularity, microstructural variability, imperfections and strut's material property associated with to the manufacturing procedure, can be gained.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>31877521</pmid><doi>10.1016/j.jmbbm.2019.103516</doi><tpages>1</tpages></addata></record> |
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subjects | Bone and Bones Finite Element Analysis Mechanical properties Micro-CT based FE modelling Stress, Mechanical Tissue Engineering Tissue Scaffolds Trabecular bone X-Ray Microtomography Zirconia scaffolds Zirconium |
title | Micro-CT based finite element modelling and experimental characterization of the compressive mechanical properties of 3-D zirconia scaffolds for bone tissue engineering |
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