IMP dehydrogenase rod/ring structures in acral melanomas

Acral lentiginous melanoma (ALM) is a rare subtype of melanoma with aggressive behavior. IMPDH enzyme, involved in de novo GTP biosynthesis, has been reported to assemble into large filamentary structures called rods/rings (RR) or cytoophidium (cellular snakes). RR assembly induces a hyperactive sta...

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Veröffentlicht in:	Pigment cell and melanoma research 2020-05, Vol.33 (3), p.490-497
Hauptverfasser:	Keppeke, Gerson D., Barcelos, Denise, Fernandes, Mariana, Comodo, Andréia N., Guimarães, Daiane P., Cardili, Leonardo, Carapeto, Fernando C. L., Andrade, Luis E. C., Landman, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	acral lentiginous melanoma Antibodies Biopsy Biosynthesis Cellular structure cutaneous malignant Genetic Heterogeneity Guanosine triphosphate Histopathology Humans IMP dehydrogenase IMP Dehydrogenase - metabolism Malignancy melanocytic nevi Melanoma Melanoma - enzymology Melanoma - pathology Nevus, Pigmented - pathology Nucleotides Paraffin Paraffins Ring structures rod/ring structures tissue micro‐array Tumor cells Tumors
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