Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus
Peripheral arterial occlusive disease (PAOD) is a disease with worldwide increasing occurrence. Diabetic patients are greatly exposed on the risk of PAOD and its complications. The aim of the study was to check the influence of preoperative HbA1C on the outcomes of patients with diabetes undergoing...
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| Veröffentlicht in: | Folia medica cracoviensia 2019, Vol.59 (1), p.49-60 |
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| creator | Wachsmann, Agnieszka Maga, Mikołaj Schönborn, Martyna Olszewska, Marta Blukacz, Mateusz Cebeńko, Małgorzata Trynkiewicz, Agnieszka Maga, Paweł |
| description | Peripheral arterial occlusive disease (PAOD) is a disease with worldwide increasing occurrence. Diabetic patients are greatly exposed on the risk of PAOD and its complications. The aim of the study was to check the influence of preoperative HbA1C on the outcomes of patients with diabetes undergoing PAOD related endovascular treatment.
The study was conducted among 59 patients with PAOD referred from the diabetic foot outpatient for endovascular treatment. They were included in one-year observation based on follow-up visits in 1, 3, 6 and 12 months a er angioplasty and divided into 2 groups basing on their preoperative glycaemia. The clinical condition of the lower limbs was assessed by use of the Rutherford classification, ankle-brachial index (ABI) and toe-brachial index (TBI). Changes in patients' quality of life (QoL) were also evaluated.
Reintervention within 12 months were less frequent in patients with HbA1C ≤8.0% than in HbA1C >8.0% patients (9.09% vs. 35.48%, p = 0.03). TBI of the treated limb was lower in patients with elevated than in patients with proper glycaemia at 6 month [0.2 (0.0-0.38) vs. 0.38 (0.31-0.46); p |
| doi_str_mv | 10.24425/fmc.2019.128025 |
| format | Article |
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The study was conducted among 59 patients with PAOD referred from the diabetic foot outpatient for endovascular treatment. They were included in one-year observation based on follow-up visits in 1, 3, 6 and 12 months a er angioplasty and divided into 2 groups basing on their preoperative glycaemia. The clinical condition of the lower limbs was assessed by use of the Rutherford classification, ankle-brachial index (ABI) and toe-brachial index (TBI). Changes in patients' quality of life (QoL) were also evaluated.
Reintervention within 12 months were less frequent in patients with HbA1C ≤8.0% than in HbA1C >8.0% patients (9.09% vs. 35.48%, p = 0.03). TBI of the treated limb was lower in patients with elevated than in patients with proper glycaemia at 6 month [0.2 (0.0-0.38) vs. 0.38 (0.31-0.46); p <0.008] and 12 month follow-up [0.17 (0.0-0.27) vs. 0.32 (0.25-0.38); p <0,001]. The rate of healed ulcerations after 6 months was higher in patients HbA1C ≤8.0% (45.0% vs. 16.13%; p = 0.02) and they had significantly greater improvement of QoL.
Results of this study shows that preoperative level of glycaemia is an important factor for long-term prognosis in diabetic patients with PAOD. Elevated HbA1C level decreases significantly long-term improvement of QoL in DM patients undergoing endovascular treatment.</description><identifier>ISSN: 0015-5616</identifier><identifier>DOI: 10.24425/fmc.2019.128025</identifier><identifier>PMID: 31180075</identifier><language>eng</language><publisher>Poland</publisher><subject>Aged ; Angioplasty ; Ankle Brachial Index ; Arterial Occlusive Diseases - therapy ; Computed Tomography Angiography ; Diabetes Complications - therapy ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; Endovascular Procedures ; Female ; Glycated Hemoglobin A - metabolism ; Humans ; Hypoglycemic Agents - therapeutic use ; Ischemia - therapy ; Longitudinal Studies ; Lower Extremity - blood supply ; Male ; Middle Aged ; Peripheral Arterial Disease - therapy ; Preoperative Period ; Prognosis ; Prospective Studies ; Quality of Life ; Recurrence ; Stents ; Ultrasonography, Doppler</subject><ispartof>Folia medica cracoviensia, 2019, Vol.59 (1), p.49-60</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31180075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wachsmann, Agnieszka</creatorcontrib><creatorcontrib>Maga, Mikołaj</creatorcontrib><creatorcontrib>Schönborn, Martyna</creatorcontrib><creatorcontrib>Olszewska, Marta</creatorcontrib><creatorcontrib>Blukacz, Mateusz</creatorcontrib><creatorcontrib>Cebeńko, Małgorzata</creatorcontrib><creatorcontrib>Trynkiewicz, Agnieszka</creatorcontrib><creatorcontrib>Maga, Paweł</creatorcontrib><title>Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus</title><title>Folia medica cracoviensia</title><addtitle>Folia Med Cracov</addtitle><description>Peripheral arterial occlusive disease (PAOD) is a disease with worldwide increasing occurrence. Diabetic patients are greatly exposed on the risk of PAOD and its complications. The aim of the study was to check the influence of preoperative HbA1C on the outcomes of patients with diabetes undergoing PAOD related endovascular treatment.
The study was conducted among 59 patients with PAOD referred from the diabetic foot outpatient for endovascular treatment. They were included in one-year observation based on follow-up visits in 1, 3, 6 and 12 months a er angioplasty and divided into 2 groups basing on their preoperative glycaemia. The clinical condition of the lower limbs was assessed by use of the Rutherford classification, ankle-brachial index (ABI) and toe-brachial index (TBI). Changes in patients' quality of life (QoL) were also evaluated.
Reintervention within 12 months were less frequent in patients with HbA1C ≤8.0% than in HbA1C >8.0% patients (9.09% vs. 35.48%, p = 0.03). TBI of the treated limb was lower in patients with elevated than in patients with proper glycaemia at 6 month [0.2 (0.0-0.38) vs. 0.38 (0.31-0.46); p <0.008] and 12 month follow-up [0.17 (0.0-0.27) vs. 0.32 (0.25-0.38); p <0,001]. The rate of healed ulcerations after 6 months was higher in patients HbA1C ≤8.0% (45.0% vs. 16.13%; p = 0.02) and they had significantly greater improvement of QoL.
Results of this study shows that preoperative level of glycaemia is an important factor for long-term prognosis in diabetic patients with PAOD. Elevated HbA1C level decreases significantly long-term improvement of QoL in DM patients undergoing endovascular treatment.</description><subject>Aged</subject><subject>Angioplasty</subject><subject>Ankle Brachial Index</subject><subject>Arterial Occlusive Diseases - therapy</subject><subject>Computed Tomography Angiography</subject><subject>Diabetes Complications - therapy</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Endovascular Procedures</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Ischemia - therapy</subject><subject>Longitudinal Studies</subject><subject>Lower Extremity - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peripheral Arterial Disease - therapy</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Recurrence</subject><subject>Stents</subject><subject>Ultrasonography, Doppler</subject><issn>0015-5616</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtvGzEQhFnEiATFfaqAZZpT-LgHrxSE2DEgII1dC3vknkSDPJ5Jngz9qfzGUIizzS4wsx8GQ8hXzrairkXzY_R6Kxjvt1woJppPZM0Yb6qm5e2K3Kf0ysq0qlZN_ZmsJOeKsa5Zkz9PfgadaRjpHLEKM0bI9oL05K4aMhp6BvTh5MJgJ7rje-rwgo6GifLqihBpWLIOHtMNgZMJF0h6cUXIESF7nDItn3OhljPRd5vPVEebrQZHnfUDtUmf0Vu4-fIZqQ5LTHjjGQsD5sL26JzNS_pC7kZwCe8_9oa8PPx83v-qDr8fn_a7QzVz0eaq05ozaBXXmjW9FI0U3dDp2oxiUGqsR1nawJH1BkyrBfRKGdX2IFrshBGd3JDv_7hzDG8Lpnz0JWUJAROGJR2FlKzrZa1u1m8f1mXwaI5ztB7i9fi_Y_kXUuuAlg</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Wachsmann, Agnieszka</creator><creator>Maga, Mikołaj</creator><creator>Schönborn, Martyna</creator><creator>Olszewska, Marta</creator><creator>Blukacz, Mateusz</creator><creator>Cebeńko, Małgorzata</creator><creator>Trynkiewicz, Agnieszka</creator><creator>Maga, Paweł</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2019</creationdate><title>Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus</title><author>Wachsmann, Agnieszka ; Maga, Mikołaj ; Schönborn, Martyna ; Olszewska, Marta ; Blukacz, Mateusz ; Cebeńko, Małgorzata ; Trynkiewicz, Agnieszka ; Maga, Paweł</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-7cc10a681cc059325327b7c4df2b88f4f3000ef09dad6c2a988d869a26e72d273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Angioplasty</topic><topic>Ankle Brachial Index</topic><topic>Arterial Occlusive Diseases - therapy</topic><topic>Computed Tomography Angiography</topic><topic>Diabetes Complications - therapy</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Endovascular Procedures</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Ischemia - therapy</topic><topic>Longitudinal Studies</topic><topic>Lower Extremity - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peripheral Arterial Disease - therapy</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Recurrence</topic><topic>Stents</topic><topic>Ultrasonography, Doppler</topic><toplevel>online_resources</toplevel><creatorcontrib>Wachsmann, Agnieszka</creatorcontrib><creatorcontrib>Maga, Mikołaj</creatorcontrib><creatorcontrib>Schönborn, Martyna</creatorcontrib><creatorcontrib>Olszewska, Marta</creatorcontrib><creatorcontrib>Blukacz, Mateusz</creatorcontrib><creatorcontrib>Cebeńko, Małgorzata</creatorcontrib><creatorcontrib>Trynkiewicz, Agnieszka</creatorcontrib><creatorcontrib>Maga, Paweł</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Folia medica cracoviensia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wachsmann, Agnieszka</au><au>Maga, Mikołaj</au><au>Schönborn, Martyna</au><au>Olszewska, Marta</au><au>Blukacz, Mateusz</au><au>Cebeńko, Małgorzata</au><au>Trynkiewicz, Agnieszka</au><au>Maga, Paweł</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus</atitle><jtitle>Folia medica cracoviensia</jtitle><addtitle>Folia Med Cracov</addtitle><date>2019</date><risdate>2019</risdate><volume>59</volume><issue>1</issue><spage>49</spage><epage>60</epage><pages>49-60</pages><issn>0015-5616</issn><abstract>Peripheral arterial occlusive disease (PAOD) is a disease with worldwide increasing occurrence. Diabetic patients are greatly exposed on the risk of PAOD and its complications. The aim of the study was to check the influence of preoperative HbA1C on the outcomes of patients with diabetes undergoing PAOD related endovascular treatment.
The study was conducted among 59 patients with PAOD referred from the diabetic foot outpatient for endovascular treatment. They were included in one-year observation based on follow-up visits in 1, 3, 6 and 12 months a er angioplasty and divided into 2 groups basing on their preoperative glycaemia. The clinical condition of the lower limbs was assessed by use of the Rutherford classification, ankle-brachial index (ABI) and toe-brachial index (TBI). Changes in patients' quality of life (QoL) were also evaluated.
Reintervention within 12 months were less frequent in patients with HbA1C ≤8.0% than in HbA1C >8.0% patients (9.09% vs. 35.48%, p = 0.03). TBI of the treated limb was lower in patients with elevated than in patients with proper glycaemia at 6 month [0.2 (0.0-0.38) vs. 0.38 (0.31-0.46); p <0.008] and 12 month follow-up [0.17 (0.0-0.27) vs. 0.32 (0.25-0.38); p <0,001]. The rate of healed ulcerations after 6 months was higher in patients HbA1C ≤8.0% (45.0% vs. 16.13%; p = 0.02) and they had significantly greater improvement of QoL.
Results of this study shows that preoperative level of glycaemia is an important factor for long-term prognosis in diabetic patients with PAOD. Elevated HbA1C level decreases significantly long-term improvement of QoL in DM patients undergoing endovascular treatment.</abstract><cop>Poland</cop><pmid>31180075</pmid><doi>10.24425/fmc.2019.128025</doi><tpages>12</tpages></addata></record> |
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| subjects | Aged Angioplasty Ankle Brachial Index Arterial Occlusive Diseases - therapy Computed Tomography Angiography Diabetes Complications - therapy Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Endovascular Procedures Female Glycated Hemoglobin A - metabolism Humans Hypoglycemic Agents - therapeutic use Ischemia - therapy Longitudinal Studies Lower Extremity - blood supply Male Middle Aged Peripheral Arterial Disease - therapy Preoperative Period Prognosis Prospective Studies Quality of Life Recurrence Stents Ultrasonography, Doppler |
| title | Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus |
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