Further characterization of the synergistic activation mechanism of cationic channels by M2 and M3 muscarinic receptors in mouse intestinal smooth muscle cells

In mouse ileal myocytes, muscarinic receptor-mediated cationic current (mIcat) occurs mainly through synergism of M2 and M3 subtypes involving Gi/o-type GTP-binding proteins and phospholipase C (PLC). We have further studied the M2/M3 synergistic pathway. Carbachol-induced mIcat was markedly depress...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2020-03, Vol.318 (3), p.C514-C523
Hauptverfasser:	Tanahashi, Yasuyuki, Katsurada, Taisuke, Inasaki, Noriko, Uchiyama, Mai, Sakamoto, Takashi, Yamamoto, Masayuki, Matsuyama, Hayato, Komori, Seiichi, Unno, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Carbachol Chelerythrine GTP-binding protein Heparin Intestine Myocytes Neuropeptide Y Phosphatidylinositol 4,5-diphosphate Phospholipase C Signal transduction Smooth muscle
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